Neurohistology And Imaging Techniques
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Neurohistology And Imaging Techniques
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Author : Radek Pelc
language : en
Publisher: Humana
Release Date : 2020-06-25
Neurohistology And Imaging Techniques written by Radek Pelc and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-25 with Medical categories.
This volume explores major light microscopic imaging modalities that can be used to view nervous tissue, and discusses the steps needed to use each of them, and ways to interpret the data. The chapters in this book cover topics such as atlasing of insect brain; neuroanatomical tracing through fluorochrome expression; fluorescent probes for amyloids; or optical clearing for ultramicroscopy of GFP-expressing tissues. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and cutting-edge, Neurohistology and Imaging Techniques is a valuable resource for both expert and novice users of major light microscopic imaging techniques, and those interested in exploring alternate imaging tools.
3d Imaging Neuroscience And Sepsis Research Modern Methods And Technological Advances
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Author : Aylin Gökhan
language : en
Publisher: BZT TURAN PUBLISHING HOUSE
Release Date : 2024-12-20
3d Imaging Neuroscience And Sepsis Research Modern Methods And Technological Advances written by Aylin Gökhan and has been published by BZT TURAN PUBLISHING HOUSE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-20 with Medical categories.
Preface: The continuous advancement of science and medicine is pivotal in the quest to protect and improve human health. This book aims to present the latest perspectives in the fields of neuroscience and sepsis research, highlighting modern methodologies and technological innovations. The first chapter introduces 3D histological imaging techniques, covering conventional methods such as optical imaging, electron microscopy, and other imaging technologies. It also delves into post-imaging processing and analysis, including image preprocessing, segmentation, 3D reconfiguration, and both quantitative and qualitative analyses. The second chapter explores the diverse applications of 3D histological imaging. It addresses its use in neurohistology, cancer research, developmental biology, and other medical and biological fields. The chapter also discusses current developments and future perspectives in 3D imaging. In the third chapter, the book provides a comprehensive histopathological overview of Chronic Traumatic Encephalopathy (CTE), examining its epidemiology, histopathological markers, neuropathology, and staging. The macroscopic and microscopic pathology of CTE, clinical markers, and future research directions are also discussed. Chapter four focuses on migraines, detailing their history, classifications, symptoms, etiology, epidemiology, pathophysiology, diagnosis, management, and treatments. It also covers patient education, prognosis, complications, prevention, and ongoing research, including gender-based differences and potential preventive strategies. The fifth chapter presents insights into the use of adipose-derived mesenchymal stem cells (ASCs) in treating diabetic neuropathy, using various animal models. It discusses the mechanisms of action of ASCs, challenges in their use, and future directions for improving this therapeutic method. Chapter six offers clinical insights into experimental sepsis research, defining sepsis, its mechanisms, pathophysiological alterations, clinical manifestations, diagnosis, predictive biomarkers, and treatment. Innovations and future directions in sepsis research are also solutions to the challenges in health highlighted. The seventh chapter examines experimental animal models that mimic sepsis in humans. It emphasizes the importance of these models, detailing commonly used small and large animal models, standardization, model variability, and comparative analysis of different sepsis induction methods. The eighth chapter discusses the role of artificial intelligence in sepsis research, focusing on predictive analytics, early detection, machine learning, deep learning models, ethical considerations, and future challenges and directions in AI applications. Our aim is to provide researchers and clinicians with an in-depth understanding of new microscopy techniques, neuroscience, and the complexities of sepsis. We seek to inspire the development of innovative sciences. Each chapter is designed to advance current knowledge and pave the way for future research and practical applications. This book aspires to be an indispensable resource for researchers, academics, clinicians, and students in the health sciences. We sincerely hope that the insights and innovations presented herein will have a lasting and positive impact on human health. This book is dedicated to my doctoral thesis advisor, Prof. Dr. Meral Baka (1955- 2024), who passed away in the first month of this year.
Oxford Handbook Of Cognitive Archaeology
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Author :
language : en
Publisher: Oxford University Press
Release Date : 2024-03-12
Oxford Handbook Of Cognitive Archaeology written by and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-12 with Psychology categories.
Cognitive Archaeology is a relatively young though fast growing discipline. The intellectual heart of cognitive archaeology is archaeology, the discipline that investigates the only direct evidence of the actions and decisions of prehistoric people. Its theories and methods are an eclectic mix of psychological, neuroscientific, paleoneurological, philosophical, anthropological, ethnographic, comparative, aesthetic, and experimental theories, methods, and models, united only by their focus on cognition. The Oxford Handbook of Cognitive Archaeology is a landmark publication, showcasing the theories, methods, and accomplishments of archaeologists who investigate the human mind, including its evolutionary development, its ideation (thoughts and beliefs), and its very nature-through material forms. The volume encompasses the wide spectrum of the discipline, showcasing contributions from more than 50 established and emerging scholars from Europe, Africa, Asia, Australia, and the Americas. Prominent among these are contributions that discuss the epistemological frameworks of both the evolutionary and ideational approaches and the leading theories that ground interpretations. Significantly, the majority of chapters deliver substantive contributions that analyze specific examples of material culture, from the oldest known stone tools to ceramic and rock art traditions of the recent millennium. These examples include the gamut of methods and techniques, including typology, replication studies, cha?nes operatoires, neuroarchaeology, ethnographic comparison, and the direct historical approach. In addition, the book begins with retrospective essays by several of the pioneers of cognitive archaeology, presenting a broad range of state-of-the-art investigations into cognitive abilities, tackling thorny issues like the cognitive status of Neandertals, and concluding with speculative essays about the future of an archaeology of mind, and of the mind itself.
Plant Embryogenesis
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Author : Minako Ueda
language : en
Publisher: MDPI
Release Date : 2021-09-01
Plant Embryogenesis written by Minako Ueda and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-01 with Science categories.
Despite intense investigation of plant embryogenesis, there are still various open questions in this fascinating field. For example, our knowledge is still poor in relation to the spatiotemporal dynamics and the regulatory mechanisms of various embryonic events at all levels of whole plants, organs, tissues, cells, and molecules. We also need to understand the generality and diversity of embryonic features in a diverse range of species and also the bioengineering technologies to improve reproductive traits. Therefore, in this Special Issue, we show various articles, including original research papers and reviews, to expand our knowledge on plant embryogenesis, including works spanning from the various novel protocols of model plants to the regulations of somatic embryogenesis in agricultural plants.
Minimally Invasive Neurosurgery Ii
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Author : Bernhard L. Bauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Minimally Invasive Neurosurgery Ii written by Bernhard L. Bauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In 1992 the Editors published the first volume of Minimally Invasive Neurosurgery (MIN I) which described the current state of the art in this rapidly developing field of neurosurgery and reported first clinical experiences with these new technologies. The subject of MIN II is limited to endoscopic anatomy, technical devices and surgical management of disorders suitable for endoscopic procedures. The indications and approaches in different diseases are still highly preliminary and longterm results are not yet available. The clinical value and the benefit to the patients treated with these new techniques must still be proven against the well established standards of microsurgery. This volume presents a critical update of neuroendoscopy.
Neuroproteomics
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Author : Oscar Alzate
language : en
Publisher: CRC Press
Release Date : 2009-10-26
Neuroproteomics written by Oscar Alzate and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-26 with Medical categories.
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Drug Development For Gene Therapy
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Author : Yanmei Lu
language : en
Publisher: John Wiley & Sons
Release Date : 2024-02-09
Drug Development For Gene Therapy written by Yanmei Lu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-09 with Medical categories.
Drug Development for Gene Therapy Industry-centric perspective on translational and bioanalytical challenges and best practices for gene therapies Drug Development for Gene Therapy focuses on the translational and bioanalytical challenges and best practices for gene therapy modalities, presenting a significant body of data, including information related to safety and efficacy, necessary to advance through the development pipeline into clinical use. The text covers bioanalytical methods and platforms including patient screening assays, different PCR tests, enzyme activity assays, ELISpot, NGS, LC/MS, and immunoassays, with FDA and EMA guidelines on gene therapy safety and efficacy, along with companion diagnostics regulations from US and EU perspectives. The chapters offer an in-depth discussion of the basics and best practices for translational biomarkers, bioanalysis, and developing companion diagnostics / lab tests for gene therapies in the pharma and biopharma industries. To aid in reader comprehension, the text includes clinical examples of relevant therapies in related chapters. Some of the core topics covered include study design, immunogenicity, various bioanalytical methods and their applications, and global regulatory issues. Written by two highly qualified authors with significant experience in the field, Drug Development for Gene Therapy includes information on: Bioanalytical methods to detect pre-existing antibodies against adeno-associated viruses (AAV) capsids Detection of cellular immunity and humoral response to viral capsids and transgene proteins, and immunogenicity of gene therapy products Nonclinical and clinical study considerations and methods for biodistribution and shedding Quantification of transgene protein expression and biochemical function, and substrate and distal pharmacodynamic biomarker measurements for gene therapy Detection and quantification of rAAV integration and off-target editing Current regulatory landscape for gene therapy product development and the role of biomarkers and general regulatory considerations for gene therapy companion diagnostics With comprehensive coverage of the subject, Drug Development for Gene Therapy is a must-have resource for researchers and developers in the areas of pharmaceuticals, biopharmaceuticals, and contract research organizations (CROs), along with professors, researchers, and advanced students in chemistry, biological, biomedical engineering, pharmaceuticals, and medical sciences.
Mathematical Methods In Medical Imaging Ii
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Author : David C. Wilson
language : en
Publisher:
Release Date : 1993
Mathematical Methods In Medical Imaging Ii written by David C. Wilson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Mathematics categories.
Diagnosis Of Musculoskeletal Tumors And Tumor Like Conditions
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Author : Piero Picci
language : en
Publisher: Springer Nature
Release Date : 2019-12-06
Diagnosis Of Musculoskeletal Tumors And Tumor Like Conditions written by Piero Picci and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-06 with Medical categories.
This book, now in a second revised edition, casts light on the often complex diagnosis of musculoskeletal tumors and tumor-like conditions by drawing on the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment and research in the field. The different entities are described from a multidisciplinary perspective, highlighting clinical, radiological, and histological correlations. Particular emphasis is placed on differential diagnosis, which often needs to take into account nontumoral conditions. The recent identification of further significant biological and genetic features, and the impact of these discoveries on the classification of round cell tumors, vascular lesions, and spindle/pleomorphic entities in bone, is also extensively discussed. The Rizzoli case archive dates back to September 1900 and contains the original material relating to more than 29,000 bone lesions and 11,000 soft tissue lesions. It is a fabulously rich resource, and this book will be invaluable for pathologists, radiologists, and clinicians at all levels of experience.
Neuroethology Of The Colonial Mind Ecological And Evolutionary Context Of Social Brains
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Author : J. Frances Kamhi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-02
Neuroethology Of The Colonial Mind Ecological And Evolutionary Context Of Social Brains written by J. Frances Kamhi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-02 with Nature categories.
Animal groups often display striking collective organization, which relies on social interactions. These interactions require neural substrates supporting the exchange of information among individuals and the processing of this information. The social brain hypothesis, suggested from neuroanatomical findings in primates, posits that increasing levels of sociality involve a higher investment in neural tissue to cope with social information. However, distributed cognition and swarm intelligence might alleviate the cognitive load on the individuals, and potentially reduce their neural requirements. Research on social insects, which are an exemplar of collective action, has so far produced mixed results. Individual cognition and collective action have received a lot of attention, and much progress has been done in each of those fields; however, much less is understood about how the two interact. Our goal is to aggregate theoretical and experimental research exploring the links between the complexity of individual and collective behaviors. Experimental research testing the social brain hypothesis showed little support for a general explanation across the animal kingdom. The relationship between the cognitive abilities of animals and their social interactions are much more complex than previously thought, and tackling this problem requires a better knowledge of the fundamental mechanisms underpinning socio-cognitive tasks. What is the information used by the animals during social interactions? How much information is necessary? How many neurons and which neural circuits are required for processing this information? What neural connections are important? Do these social interactions involve memory formation? How do the cognitive requirements and neural circuits vary between group members? Answering these questions will bring considerable insights into the cognitive complexity involved for social and collective behaviors. It will also advance our understanding of inter-individual cognitive variability and division of labor in most socially advanced species. This Research Topic will be a unique forum for researchers from different fields (neurogenetics, neuro-ethology, evolutionary ecology, cognitive ecology, collective animal behavior, computational modeling) working on different species to present up to date advances on the physiological correlates of social behavior and delineate future directions for the field of social neuroethology. We welcome contributions on any aspect of the cognitive requirements of social and collective behaviors, from molecular, cellular, and circuit level approaches to how individuals contribute to group action at the behavioral level. Specific areas of interest include, but are not limited to, studies on the neural underpinnings of division of labor, neuromodulation or neurogenetics of social behaviors, the neural circuits and neuroanatomical basis of group action, and how social signals affect learning and behavior. We encourage submissions that present original research and review evidence or compare data from multiple species. We hope to include work from different disciplines and on a wide range of species, including model, non-model, and wild animals, with the aim of gaining insight into the patterns of neural investment in individual cognition