Neuronal Migration Disorders
DOWNLOAD
Download Neuronal Migration Disorders PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Neuronal Migration Disorders book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Disorders Of Neuronal Migration
DOWNLOAD
Author : International Child Neurology Association
language : en
Publisher: Cambridge University Press
Release Date : 2003-01-17
Disorders Of Neuronal Migration written by International Child Neurology Association and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-17 with Medical categories.
Disorders of neuronal migration are causes of mental handicap, autism, and epilepsy. This book addresses the various aspects of neuronal migration disorders in an ordered way, to help the clinician to aquire insight and proficiency in diagnosis. Individual chapters describe subgroups including: lissencephalies, subependymal heterotopia, non-lissencephalic cortical dysplasias, anomalies of the corpus callosum, hemimegalencephaly, schizencephaly, polymicrogyria and multisystem disorders with impaired migration (such as chromosomal and metabolic syndromes). Neuroradiological and genetic data are provided.
Cellular And Molecular Control Of Neuronal Migration
DOWNLOAD
Author : Laurent Nguyen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-18
Cellular And Molecular Control Of Neuronal Migration written by Laurent Nguyen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-18 with Medical categories.
Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.
Neuronal Migration
DOWNLOAD
Author : Andrew Girard
language : en
Publisher: Nova Biomedical Books
Release Date : 2012-08
Neuronal Migration written by Andrew Girard and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08 with Medical categories.
Neuronal migration is the method by which neurons travel from their origin or birth place to their final position in the brain. In this book, the authors present topical research in the study of the disorders, genetic factors and treatment options of neuronal migration. Topics include neuronal migration disturbance in neurodevelopment disorders; candidate dyslexia susceptibility genes and disorders of neuronal migration; electrically guiding neuronal migration and membrane-cytoskeletal interactions in the regulation of neuronal migration in the adult brain. (Imprint: Nova Biomedical)
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections
DOWNLOAD
Author : J.J. LoTurco
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-06
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections written by J.J. LoTurco and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Medical categories.
Neuronal Migration Disorders
DOWNLOAD
Author : Christopher Alexander Kerfoot
language : en
Publisher:
Release Date : 2000
Neuronal Migration Disorders written by Christopher Alexander Kerfoot and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Mechanisms Of Neuronal Migration During Corticogenesis
DOWNLOAD
Author : Chiaki Ohtaka-Maruyama
language : en
Publisher: Frontiers Media SA
Release Date : 2016-07-15
Mechanisms Of Neuronal Migration During Corticogenesis written by Chiaki Ohtaka-Maruyama and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-15 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis.
The Role Of Genetic Factors In Neuronal Migration Disorders And Epilepsy
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2003
The Role Of Genetic Factors In Neuronal Migration Disorders And Epilepsy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Reelin Related Neurological Disorders And Animal Models
DOWNLOAD
Author : Laura Lossi
language : en
Publisher: Frontiers Media SA
Release Date : 2017-03-14
Reelin Related Neurological Disorders And Animal Models written by Laura Lossi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-14 with Electronic book categories.
The Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at adult ages. The Reln-encoding gene is highly conserved between mice and humans. In humans, homozygous RELN mutations cause lissencephaly with cerebellar hypoplasia, a severe neuronal migration disorder that is reminiscent of the Reeler phenotype. In addition, RELN deficiency or dysfunction is also correlated with psychiatric and cognitive disorders, such as schizophrenia, bipolar disorder and autism, as well as some forms of epilepsy and Alzheimer's disease. Despite the wealth of anatomical studies of the Reeler mouse brain, and the molecular dissection of Reln signaling mechanisms, the consequences of Reln deficiency on the development and function of the human brain are not yet completely understood. This Research Topic include reviews that summarize our current knowledge of the molecular aspects of Reln function, original articles that advance our understanding of its expression and function in different brain regions, and reviews that critically assess the potential role of Reln in human psychiatric and cognitive disorders.
Intrinsic Mechanisms Of Neuronal Migration Under Physiological And Pathological Conditions
DOWNLOAD
Author : Cédric Bressan
language : en
Publisher:
Release Date : 2021
Intrinsic Mechanisms Of Neuronal Migration Under Physiological And Pathological Conditions written by Cédric Bressan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
The ability of cell to migrate away from their sites of production is a major process during embryonic and postnatal brains development allowing for a correct positioning of cells. During adulthood, in the central nervous system, cell migration is still present and, under physiological conditions, is associated with neurogenic niches of the subventricular zone and the dentate gyrus. Some pathologies or brain damaged could de-route migratory neurons away from their normal paths of migration to lesions sites. It should be also mentioned that during embryonic development, migration-associated disorders could lead to brain malformation resulting in cognitive disorder or epilepsy. Migratory behaviors of cells is determined by a complex mixture of extrinsic molecular cues, physical scaffold, or electrical gradient. The integration of these signals at the cellular level creates a coordinated response of intracellular elements like cytoskeleton, mitochondria, or autophagy. In this work, I studied the role of autophagy in neuronal migration under physiological and pathological conditions by using a migration of neuroblasts from the subventricular zone to the olfactory bulb along the rostral migratory stream as model system. In the first chapter of my thesis, I studied the contribution of autophagy in the control of cell migration under physiological conditions. We showed that autophagy is spatially and temporally regulated in migrating neuroblasts and maintains a normal rate of migratory event. This process is controlled by intracellular ATP/ADP level via the activation of AMPK In the second part of this work, I focused on mutation for paired cadherins Fat4 and Dchs1 leading to periventricular neuronal heterotopia phenotypes in humans. By grafting in the pups with NPCs derived from human iPSC with mutation form Fat4 or Dchs1, I showed default of migration in vivo of NPCs with these two mutations. We also showed that these cells exhibit altered autophagy flux associated with a decreased in lysosomal vesicles.
The Extracellular Environment In Controlling Neuronal Migration During Neocortical Development
DOWNLOAD
Author : Yuki Hirota
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-30
The Extracellular Environment In Controlling Neuronal Migration During Neocortical Development written by Yuki Hirota and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-30 with Science categories.