Neurosteroid Effects In The Central Nervous System

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Neurosteroid Effects In The Central Nervous System

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Author : Sheryl S. Smith
language : en
Publisher: CRC Press
Release Date : 2003-10-27

Neurosteroid Effects In The Central Nervous System written by Sheryl S. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-27 with Science categories.

Presenting a complete overview of the effects of steroid hormones in the brain and describing new methods for investigating these effects, this book discusses theories on steroid action in the central nervous system and the techniques for receptor localization and quantification and enzyme regulation. The author explores the use of transgenic/antisense strategies to determine sites and the cellular effects of steroid action in the brain. He covers steroid action on mood, cognition, sensorimotor action, neuroprotection, and plasticity, and describes methods using molecular, electrophysical, and behavioral techniques to link cellular mechanisms of steroid action with behavioral effects.

Neurosteroids

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Author : Hubert Vaudry
language : en
Publisher: Frontiers E-books
Release Date :

Neurosteroids written by Hubert Vaudry and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration did not affect the concentration of pregnenolone, dehydroepiandrosterone and their sulfate esters in the rat brain. These seminal observations led to the concept that the brain, in very much the same way as the adrenal cortex, testis, ovary and placenta, was capable of synthesizing steroids. These brain born steroids, called neurosteroids, have been found to exert a vast array of biological activities. A number of steroidogenic enzymes have now been identified in the central nervous system by immunohistochemistry and in situ hybridization, and the neuronal and hormonal mechanisms regulating the biosynthesis of neurosteroids have been partially elucidated. The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.

Handbook Of Developmental Science Behavior And Genetics

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Author : Kathryn E. Hood
language : en
Publisher: John Wiley & Sons
Release Date : 2011-06-28

Handbook Of Developmental Science Behavior And Genetics written by Kathryn E. Hood and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-28 with Psychology categories.

The Handbook of Developmental Science, Behavior, and Genetics brings together the cutting-edge theory, research and methodology that contribute to our current scientific understanding of the role of genetics in the developmental system. • Commemorates the historically important contributions made by Gilbert Gottlieb in comparative psychology and developmental science • Includes an international group of contributors who are among the most respected behavioral and biological scientists working today • Examines the scientific basis for rejecting the reductionism and counterfactual approach to understanding the links between genes, behavior, and development • Documents the current status of comparative psychology and developmental science and provides the foundation for future scientific progress in the field

Neurosteroids And Brain Function

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Author : Giovanni Biggio
language : en
Publisher: Academic Press
Release Date : 2001-09-27

Neurosteroids And Brain Function written by Giovanni Biggio and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-27 with Medical categories.

International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field. Includes a historical overview of neurosteroid research Contains a chapter on neurosteroid biosynthesis and regulation Presents current methods of neurosteroid measurement and analysis Discusses neurosteroid function in both the normal and the pathological brain Chapters address the function of neurosteroid in: Stress, Receptor plasticity and function, Learning and Memory, Alcohol use, Depression

Moods Emotions And Aging

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Author : Phyllis J. Bronson
language : en
Publisher: Bloomsbury Publishing PLC
Release Date : 2013-07-05

Moods Emotions And Aging written by Phyllis J. Bronson and has been published by Bloomsbury Publishing PLC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-05 with Health & Fitness categories.

Despite the backlash against hormone replacement therapy, the depletion of natural hormones in the female body continues to be a problem for women at middle age and beyond. Remedying the problem has proved difficult for women and doctors who are unaware of, or reluctant to prescribe, bioidential hormones—those that match identically the hormones made naturally in the human body. Moods, Emotions, and Aging: Hormones and the Mind Body Connection explains the vital link for women between hormones, mood, and wellness. It outlines the dramatic hormonal shifts that women undergo in the years before menopause, and presents an approach to combining bioidentical hormone therapy with nutrients to achieve mood balance during midlife and beyond. Phyllis Bronson explains the differences between synthetic and bioidentical hormones, and offers vignettes of women who have used bioidentical hormones to help them deal with the changes that accompany natural hormone loss. This is a groundbreaking book for general readers written by a scientist who is able to take the mystery and the hype out of the hormone controversy. It is intended to empower women, along with their doctors, to make better and more informed choices about their health and well-being as they approach a time in their lives when things can seem like they are spinning out of control. The link between hormones, mood, emotions, and overall wellbeing is a powerful one, and when women are aware of it, they can take steps to bring themselves into better balance physically and emotionally. Here, Bronson shows them how.

Molecular Mechanisms Of Hormone Actions On Behavior

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Author : Anne M. Etgen
language : en
Publisher: Academic Press
Release Date : 2010-03-16

Molecular Mechanisms Of Hormone Actions On Behavior written by Anne M. Etgen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-16 with Psychology categories.

A single volume of 31 articles, Mechanisms of Hormone Actions on Behavior is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP June 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of the mechanisms which control hormone actions on behavior. Female, male and stress hormones are discussed at the cellular, behavioral and developmental level, and sexual differentiation of the development of hormone-dependent neuronal systems, neuropeptides/neuromodulators, and steroid-inducedneuroplasticity are addressed. There is simply no other current single-volume reference with such comprehensive coverage and depth.Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 175 figures (over 50 in color). A collection of articles reviewing our fundamental knowledge of the mechanisms of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. - The most comprehensive single-volume source of up-to-date data on the mechanisms behind neuroendocrinology, with review articles covering x,y z - Chapters synthesize information otherwise dispersed across a number of journal articles and book chapters, thus saving researchers the time consuming process of finding and integrating this information themselves - Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 35% of chapters are written by international contributors - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Heavily illustrated with 175 figures, approximately 54 in color - Presents material in most visually useful form for the reader

Recent Progress And Perspectives In Neurosteroid Research

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Author : Hubert Vaudry
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-16

Recent Progress And Perspectives In Neurosteroid Research written by Hubert Vaudry and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-16 with Science categories.

New Perspectives In Neurosteroids Action A Special Player Allopregnanolone

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Author : Valerio Magnaghi
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-01

New Perspectives In Neurosteroids Action A Special Player Allopregnanolone written by Valerio Magnaghi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-01 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.

Early in the 80’s date the first observations on the existence of hormonal steroids that may be synthesized and act in the nervous system. In order to refer to these endogenous steroids, proved important to control both central and peripheral nervous system, it was proposed the term “neurosteroids” (NSs). Over the years, their importance in regulating the physiological functions of neuronal and glial cells increased progressively. These steroids can be involved in several pathophysiological conditions such as depression, anxiety, premenstrual syndrome (PMS), schizophrenia and Alzheimer disease. Among the different classes of NSs, the progestagens revealed particularly important. The progesterone metabolite 5a-pregnan-3a-ol-20-one, also named tetrahydroprogesterone or allopregnanolone (ALLO) was one of the first most important steroid that was originally shown to act as neurosteroid. ALLO is synthesized through the action of the 5aR-3a-HSD, which converts P into DHP and subsequently, via a bidirectional reaction, into ALLO. NSs exert complex effects in the nervous system through ‘classic’, genomic, and ‘non-classic’, non-genomic actions. ALLO displays a rapid ‘non-genomic’ effect, which mainly involves the potent modulation of the GABA type A (GABA-A) receptor function. Recently a membrane receptor has been identified as target for ALLO effects, i.e. the membrane progesterone receptors (mPRs) that are able to activate a signalling cascade through G protein dependent mechanisms. By these ways, ALLO is able to modulate several cell functions, acting as neurogenic molecule on neural progenitor cells, as well as by activating proliferation and differentiation of glial cells in the central and peripheral nervous system. In this topic, we review the most recent acquisitions in the field of neurosteroids, focusing our attention on ALLO because its effects on the physiology of neurons and glial cells of the central and peripheral nervous system are intriguing and could potentially lead to the development of new strategies for neuroprotection and/or regeneration of injured nervous tissues and for the treatment of neuropsychiatric disorders.

Trends In Posttraumatic Stress Disorder Research

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Author : Thomas A. Corales
language : en
Publisher: Nova Publishers
Release Date : 2005

Trends In Posttraumatic Stress Disorder Research written by Thomas A. Corales and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.

Posttraumatic Stress Disorder, or PTSD, is a psychiatric disorder that can occur following the experience or witnessing of life-threatening events such as military combat, natural disasters, terrorist incidents, serious accidents, or violent personal assaults like rape. People who suffer from PTSD often relive the experience through nightmares and flashbacks, have difficulty sleeping, and feel detached or estranged, and these symptoms can be severe enough and last long enough to significantly impair the person's daily life. PTSD is marked by clear biological changes as well as psychological symptoms. PTSD is complicated by the fact that it frequently occurs in conjunction with related disorders such as depression, substance abuse, problems of memory and cognition, and other problems of physical and mental health. The disorder is also associated with impairment of the person's ability to function in social or family life, including occupational instability, marital problems and divorces. PTSD is associated with a number of distinctive neurobiological and physiological changes. PTSD is treated by a variety of forms of psychotherapy and drug therapy. This new book presents leading research from around the world.

The Neuropharmacology Of Alcohol

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Author : Kathleen A. Grant
language : en
Publisher: Springer
Release Date : 2019-03-27

The Neuropharmacology Of Alcohol written by Kathleen A. Grant and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-27 with Medical categories.

This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research. Additionally, this book covers important topics under the heading of “experimental pharmacology” and alcohol.