Neurotoxic Factors In Parkinson S Disease And Related Disorders
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Neurotoxic Factors In Parkinson S Disease And Related Disorders
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Author : Alexander Storch
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neurotoxic Factors In Parkinson S Disease And Related Disorders written by Alexander Storch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book stems from the 2nd Parkinson's Disease Symposium on Neurotoxic Factors in Parkinson's Disease and Related Disorders, held on Augus 6-7, 1999 at the University of Ulm Medical School in Ulm at the Danube in Germany. The specific topic, neurotoxic factors in Parkinson's Disease, involves neurobiological, epidemiological and environmental factors that bring to light this second most common neurodegenerative disorder. This work is compiled by leading researchers in neurodegeneration from around the world, making it a unique, comprehensive, and useful publication.
Occupational Neurotoxicology
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Author : Lucio G. Costa
language : en
Publisher: CRC Press
Release Date : 2020-04-14
Occupational Neurotoxicology written by Lucio G. Costa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-14 with Medical categories.
First published in 1988, many chemical compounds present in workplace settings can produce a number of impairments in the human nervous system. As the situations in which neurotoxic agents have been recognized in exposed workers has grown, so has the importance of occupational neurotoxicology as a specialty. Addressing some of the most vital concerns in the field, Occupational Neurotoxicology discusses: Neurotoxic agents commonly encountered in the workplace Signs and symptoms of neurotoxicity and of the factors affecting neurotoxic effects Biological monitoring and the use of biomarkers Epidemiological methods and clinical approaches to occupational neurotoxicology The analysis of behavioral, electrophysiological, and imaging techniques in the diagnosis of neurotoxicity Occupational neurotoxicity in developing countries The evaluation and management of occupational illnesses due to neurotoxicity Occupational Neurotoxicology concisely covers important facts on the adverse effects of chemical, biological, and physical agents that can impair or alter the structure of the nervous system. Professionals and researchers in the fields of occupational medicine, toxicology, epidemiology, neurology, industrial hygiene, and psychology will all find relevant information on the health problems that can occur from exposure to neurotoxicants.
Isoquinolines And Beta Carbolines As Neurotoxins And Neuroprotectants
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Author : Lucyna Antkiewicz-Michaluk
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-06
Isoquinolines And Beta Carbolines As Neurotoxins And Neuroprotectants written by Lucyna Antkiewicz-Michaluk and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-06 with Medical categories.
The specific topic, “Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson`S Disease Therapy,” was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson`s disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): ß-carbolines (BCs) and tetrahydroisoquinolines (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances. In this book we are going to summarize, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties. Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease.
Clinical Neurotoxicology E Book
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Author : Michael R. Dobbs
language : en
Publisher: Elsevier Health Sciences
Release Date : 2009-07-22
Clinical Neurotoxicology E Book written by Michael R. Dobbs and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-22 with Medical categories.
Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You’ll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors—such as heavy metals and pesticides—and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. Provides a complete listing of neurotoxic agents—from manufactured to environmental—so you get comprehensive, clinical coverage. Covers how toxins manifest themselves according to age and co-morbidity so that you can address the needs of all your patients. Offers broad and in-depth coverage of toxins from all over the world through contributions by leading authorities and up-and-coming clinical neurotoxicologists. Features discussion of controversial and unusual topics such as Gulf War Syndrome, Parkinson’s Disease, motor neuron disease, as well as other issues that are still in question.
Etiology Of Parkinson S Disease
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Author : Jonas H. Ellenberg
language : en
Publisher: CRC Press
Release Date : 1995-03-01
Etiology Of Parkinson S Disease written by Jonas H. Ellenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Medical categories.
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Neuropsychopharmacotherapy
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Author : Peter Riederer
language : en
Publisher: Springer Nature
Release Date : 2022-11-04
Neuropsychopharmacotherapy written by Peter Riederer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-04 with Medical categories.
This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.
Parkinson S Disease And Related Disorders
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Author : Peter Riederer
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-11-23
Parkinson S Disease And Related Disorders written by Peter Riederer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-23 with Medical categories.
This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.
Oxidative Stress And Redox Signalling In Parkinson S Disease
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Author : Rodrigo Franco
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-07-25
Oxidative Stress And Redox Signalling In Parkinson S Disease written by Rodrigo Franco and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-25 with Medical categories.
Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.
Milestones In Neurotoxicity And Neuroprotection A Tribute To Professor Toshiharu Nagatsu
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Author : M. Naoi
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-09-25
Milestones In Neurotoxicity And Neuroprotection A Tribute To Professor Toshiharu Nagatsu written by M. Naoi and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-25 with Medical categories.
This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences. The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.
Neuropsychiatric Disorders
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Author : Manfred Gerlach
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-28
Neuropsychiatric Disorders written by Manfred Gerlach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-28 with Medical categories.
This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.