Neurotransmitter Mediated Activity Spatially Controls Neuronal Migration In The Zebrafish Cerebellum
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Neurotransmitter Mediated Activity Spatially Controls Neuronal Migration In The Zebrafish Cerebellum
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Author : Ulrike Theisen
language : en
Publisher:
Release Date : 2018
Neurotransmitter Mediated Activity Spatially Controls Neuronal Migration In The Zebrafish Cerebellum written by Ulrike Theisen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Neuronal migration during embryonic development contributes to functional brain circuitry. Many neurons migrate in morphologically distinct stages that coincide with differentiation, requiring tight spatial regulation. It had been proposed that neurotransmitter-mediated activity could exert this control. Here, we demonstrate that intracellular calcium transients occur in cerebellar neurons of zebrafish embryos during migration. We show that depolarization increases and hyperpolarization reduces the speed of tegmental hindbrain neurons using optogenetic tools and advanced track analysis optimized for in vivo migration. Finally, we introduce a compound screening assay to identify acetylcholine (ACh), glutamate, and glycine as regulators of migration, which act regionally along the neurons' route. We summarize our findings in a model describing how different neurotransmitters spatially interact to control neuronal migration. The high evolutionary conservation of the cerebellum and hindbrain makes it likely that polarization state-driven motility constitutes an important principle in building a functional brain.
Patterning And Cell Type Specification In The Developing Cns And Pns
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Author : Bin Chen
language : en
Publisher: Academic Press
Release Date : 2020-06-02
Patterning And Cell Type Specification In The Developing Cns And Pns written by Bin Chen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-02 with Medical categories.
Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems. Features leading experts in various subfields as section editors and article authors Contains articles that are peer reviewed to ensure accuracy, thoroughness and scholarship Covers mechanisms which control regional specification, regulate proliferation of neuronal progenitors, control differentiation and survival of specific neuronal subtypes, and control the development of non-neural cells
Molecular Mechanisms And Pathways In Cerebellar Function
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Author : Catarina Osorio
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-21
Molecular Mechanisms And Pathways In Cerebellar Function written by Catarina Osorio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-21 with Science categories.
Cellular Migration And Formation Of Axons And Dendrites
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Author : Bin Chen
language : en
Publisher: Academic Press
Release Date : 2020-05-29
Cellular Migration And Formation Of Axons And Dendrites written by Bin Chen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-29 with Medical categories.
Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms which regulate the formation of axons and dendrites and cellular migration Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Aquaculture Pharmacology
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Author : Frederick S.B. Kibenge
language : en
Publisher: Academic Press
Release Date : 2020-10-18
Aquaculture Pharmacology written by Frederick S.B. Kibenge and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-18 with Technology & Engineering categories.
Aquaculture Pharmacology is a reliable, up-to-date, "all inclusive" reference and guide that provides an understanding of practical drug information for the aquaculture industry. This book covers the sources, chemical properties, and mechanisms of action of drugs, and the biological systems upon which they act. It covers various drug interactions, therapeutic uses of drugs, as well as legal considerations within the industry as a whole. It presents the four main groups of drugs used in fish, crustaceans and molluscs and includes disinfectants, antimicrobial drugs, antiparasitic agents, and anesthetics, and identifies areas where more research is needed to generate more knowledge to support a sustainable aquaculture industry. With the burgeoning international aquaculture expansion and expanding global trade in live aquatic animals and their products this book is useful to bacteriologists, mycologists, aquaculturists, clinical practitioners in aquatic animal health and all those in industry, government or academia who are interested in aquaculture, fisheries and comparative biology. Presents clinical information for the three major aquatic food animals (fish, crustaceans and molluscs) Facilitates research to develop vaccines or other similar pathogen mitigation measures Provides the latest advancements in the field including regulated pharmaceuticals for use in fisheries and aquaculture
Handbook Of The Cerebellum And Cerebellar Disorders
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Author : Mario Manto
language : en
Publisher: Springer
Release Date : 2012-08-04
Handbook Of The Cerebellum And Cerebellar Disorders written by Mario Manto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-04 with Medical categories.
Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.
Development Of The Cerebellar System
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Author : Joseph Altman
language : en
Publisher: CRC Press
Release Date : 1997
Development Of The Cerebellar System written by Joseph Altman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
This book is an outstanding presentation of what happens during normal cerebellar development.
Neuroanatomy Of The Zebrafish Brain
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Author : Mario F. Wulliman
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Neuroanatomy Of The Zebrafish Brain written by Mario F. Wulliman and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Methods Of Behavior Analysis In Neuroscience
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Author : Jerry J. Buccafusco
language : en
Publisher: CRC Press
Release Date : 2000-08-29
Methods Of Behavior Analysis In Neuroscience written by Jerry J. Buccafusco and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-29 with Medical categories.
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Extracellular And Intracellular Signaling
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Author : James D. Adams
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011
Extracellular And Intracellular Signaling written by James D. Adams and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.