Molecular Mechanisms And Pathways In Cerebellar Function
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Molecular Mechanisms And Pathways In Cerebellar Function
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Author : Catarina Osorio
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-21
Molecular Mechanisms And Pathways In Cerebellar Function written by Catarina Osorio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-21 with Science categories.
Development Of The Cerebellum From Molecular Aspects To Diseases
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Author : Hassan Marzban
language : en
Publisher: Springer
Release Date : 2017-07-27
Development Of The Cerebellum From Molecular Aspects To Diseases written by Hassan Marzban and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-27 with Medical categories.
The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.
Cellular And Molecular Mechanisms Underlying Higher Neural Functions
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Author : A. I. Selverston
language : en
Publisher:
Release Date : 1994-06-30
Cellular And Molecular Mechanisms Underlying Higher Neural Functions written by A. I. Selverston and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-30 with Medical categories.
Despite the remarkable advances made in molecular neurobiology over the last ten years, very little progress has been made towards understanding how the brain performs higher functions: cognition, behavior, learning, and memory. One of the greatest challenges facing modern neurobiology, therefore, is the integration of data that comes from disparate levels of analysis. This volume presents the results of the Dahlem conference convened to address these issues. The purpose of the conference was to bring together brain researchers, who approach their work at different conceptual levels, to consider how their results might be synthesized into a more integrated view of how the brain works. To try and accomplish this, two specific examples were chosen: the modulation of neural circuits and the phenomena of long-term potentiation (LTP). Neuromodulation has been studied from the molecular to the behavioral level with dramatic breakthroughs at the circuit level over the last five years. Due to the possibility that it may be the cellular mechanism for certain types of learning and memory, LTP has also been studied at different levels. To assist in understanding LTP and neuromodulation at the molecular, cellular, circuit, and behavioral levels, the background papers written for the meeting are included in this volume. The conference itself was devoted to discussing LTP and neuromodulation from the perspective of each of the different levels, and the results of these discussions are presented in the group reports. Particular emphasis was given to a consideration of how the rapid progress in molecular and cellular neurobiology can be integrated into systems and behavioral neurobiology. Specific suggestions for future research in both areas were discussed thoroughly. This volume presents what is most probably the most authoritative, up-to-date assessment of LTP and neuromodulation currently available. Goal of this Dahlem Workshop: to apply new cellular and molecular concepts to the understanding of plasticity in synapses, cells, local circuits, and defined systems in the mature brain.
Handbook Of The Cerebellum And Cerebellar Disorders
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Author : Mario Manto
language : en
Publisher: Springer
Release Date : 2012-08-04
Handbook Of The Cerebellum And Cerebellar Disorders written by Mario Manto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-04 with Medical categories.
Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.
The Cerebellum And Cognition
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Author :
language : en
Publisher: Academic Press
Release Date : 1997-10-02
The Cerebellum And Cognition written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-02 with Science categories.
The Cerebellum and Cognition pulls together a preeminent group of authors. The cerebellum has been previously considered as a highly complex structure involved only with motor control. The cerebellum is essential to nonmotor functions, and recent research has revealed new medically important roles of the cerebellum and cognitive processes. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Comprehensive coverage of cerebellum in motor control and cognition New developments regarding the cerebellum and motor systems Therapeutic implications of cerebellar contributions to cognition Preeminent group of contributors
Cerebellar Disorders
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Author : Mario Ubaldo Manto
language : en
Publisher: Cambridge University Press
Release Date : 2010-03-25
Cerebellar Disorders written by Mario Ubaldo Manto and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-25 with Medical categories.
During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.
Development Of The Cerebellar System
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Author : Joseph Altman
language : en
Publisher: CRC Press
Release Date : 1997
Development Of The Cerebellar System written by Joseph Altman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
This book is an outstanding presentation of what happens during normal cerebellar development.
Polyglutamine Disorders
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Author : Clévio Nóbrega
language : en
Publisher: Springer
Release Date : 2018-02-09
Polyglutamine Disorders written by Clévio Nóbrega and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-09 with Medical categories.
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
The Cerebellum As A Neuronal Machine
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Author : John C. Eccles
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
The Cerebellum As A Neuronal Machine written by John C. Eccles and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
This book has had a three-fold origin, corresponding to the discoveries made by the three authors and their collaborators during the last few years - mostly since 1962. A most fruitful symposium on the cerebellum was held in Tokyo at the time of the International Physiological Congress in September 1965, and there was then formulated the project of writing this book so as to organize all this new knowledge and make it readily available, and to give opportunity for the con ceptual developments that may be seen in Chapters XI, XII and XV in particular. The present account of the physiological properties of the cerebellar cortex is based to a large extent on systematic investigations that were concerned with discovering the mode of operation of the constituent neuronal elements of the cerebellar cortex. This work was carried out in the Physiology Department of the Australian National University from 1963 to 1966 in collaboration with several visiting scientists - initially Drs. ANDERSEN, OscARssaN and VooRHOEVE and later Drs. LuNAs, SAsAKI and STRATA - to all of whom grateful thanks are extended for a great many of the figures, and even more significantly for the original and critical contributions that they made to so many aspects of this exploration into the mode of operation of the neural machinery of the cerebellar cortex.
Neurodegenerative Diseases
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Author : Nagehan Ersoy Tunalı
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-01-20
Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.
Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.