Neurovascular Health Insights A Powerful Tool To Understand And Prognose Neurocognitive Decline
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Neurovascular Health Insights A Powerful Tool To Understand And Prognose Neurocognitive Decline
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Author : Michael Ntim
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-27
Neurovascular Health Insights A Powerful Tool To Understand And Prognose Neurocognitive Decline written by Michael Ntim and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-27 with Science categories.
Age-related dementias are expected to impact negatively about 150 million people by 2050. Neurovascular health is deeply correlated with the onset of dementia symptoms and is critical in slowing down the impending public health problem of neurocognitive decline in an aging population. Neurovascular health offers insight into understanding most neurological diseases' cellular and molecular basis and prognosis. Improving neurovascular health by maintaining its healthy metabolic function appears particularly important, as cardiovascular changes and related impairments may affect the brain at the neurovascular level. When the neurovascular unit (NVU) is damaged, neurovascular health is impaired, potentially leading to white matter changes, microinfarcts and hemorrhages, and large artery strokes causing cognitive decline. As such it is important to maintain a healthy neurovascular system, particularly in the aging population subject to cognitive decline. Hyperglycaemic stress, for example, can impact the function of NVUs and cause inflammation, as well as an unbalance in cholesterol homeostasis. Cholesterol homeostasis is well known to be involved in maintaining the health of NVUs. Literature shows evidence that cholesterol homeostasis is essential in keeping stable levels associated with improved cognitive function in Alzheimer’s Disease (AD) patients, as well as being associated with lower cognitive functions with a potential implication in dementia if unbalanced. Hence, it is not far-fetched to link neovascularization to neurocognition.