New Animal Models Of Human Neurological Diseases
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New Animal Models Of Human Neurological Diseases
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Author : Philippe Poindron
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2008-01-01
New Animal Models Of Human Neurological Diseases written by Philippe Poindron and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Medical categories.
This publication describes in detail some animal models of outstanding importance for the study of human neurological diseases. An introductory article provides a definition of animal models, looks at the history and ethics of their use, and highlights the reasons why animal models are so useful in scientific research. The following chapters present some of the newer models which play a key role in the study of amyotrophic lateral sclerosis, multiple sclerosis, stroke and peripheral neuropathy. Their specific features are detailed in the method section of each paper, and their application to the study of human neurological diseases is discussed in a comprehensive manner, i.e. limits and challenges posed by these models are evaluated and potential improvements suggested. A valuable single source of information, this book is recommended reading for neuroscientists as well as for neurologists and neurosurgeons interested in preclinical research on human neurological diseases.
Central Nervous System Diseases
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Author : Dwaine F. Emerich
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-11-24
Central Nervous System Diseases written by Dwaine F. Emerich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-24 with Medical categories.
Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Animal Models For Neurological Disorders
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Author : Anil Kumar
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-12-24
Animal Models For Neurological Disorders written by Anil Kumar and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-24 with Science categories.
Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule. Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate. Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.
Animal Models For The Study Of Human Disease
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Science categories.
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
Improving The Utility And Translation Of Animal Models For Nervous System Disorders
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2013-03-25
Improving The Utility And Translation Of Animal Models For Nervous System Disorders written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-25 with Medical categories.
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Mouse Models In The Study Of Genetic Neurological Disorders
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Author : Brian Popko
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mouse Models In The Study Of Genetic Neurological Disorders written by Brian Popko and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.
Animal Models Of Neurological Disease
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Author : Alan A. Boulton
language : en
Publisher:
Release Date : 1992
Animal Models Of Neurological Disease written by Alan A. Boulton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
The use of animal models continues to be the most reliable way of studying pathophysiologic mechanisms as well as treatments for neurological disorders. In two companion volumes, Animal Models of Neurological Disease highlights new information and techniques available in this rapidly growing area. This volume of Neuromethods focuses on commonly studied neurodegenerative diseases, highlighting the similarities and differences between the human condition and that obtained using animal models. Chapters are contributed by experts in the field and cover a variety of topics, including: the ethics of using animal models Alzheimer's disease Huntington's disease Parkinson s disease Lesch-Nyhan disease genetic and nongenetic demyelinating diseases cerebellar ataxias rodent and primate models surgical lesions neurotoxins. Boulton, Baker, and Butterworth's important new treatise on Animal Models of Neurological Disease is an outstanding guide for all researchers striving for a better understanding of neurological disease.
Animal Models Of Neurological Disorders
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Author : Puneet Kumar Bansal
language : en
Publisher: Springer
Release Date : 2018-01-17
Animal Models Of Neurological Disorders written by Puneet Kumar Bansal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-17 with Medical categories.
This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.
Therapeutic Development In The Absence Of Predictive Animal Models Of Nervous System Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-06-24
Therapeutic Development In The Absence Of Predictive Animal Models Of Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-24 with Medical categories.
Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop.
Human And Animal Models For Translational Research On Neurodegeneration Challenges And Opportunities From South America
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Author : Agustín Ibáñez
language : en
Publisher: Frontiers Media SA
Release Date : 2018-06-21
Human And Animal Models For Translational Research On Neurodegeneration Challenges And Opportunities From South America written by Agustín Ibáñez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-21 with categories.
Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.