New Approaches To The Pathogenesis Of Sudden Intrauterine Unexplained Death And Sudden Infant Death Syndrome
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New Approaches To The Pathogenesis Of Sudden Intrauterine Unexplained Death And Sudden Infant Death Syndrome
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Author : Anna M. Lavezzi
language : en
Publisher: Frontiers Media SA
Release Date : 2017-10-03
New Approaches To The Pathogenesis Of Sudden Intrauterine Unexplained Death And Sudden Infant Death Syndrome written by Anna M. Lavezzi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-03 with categories.
Sudden Infant Death Syndrome (SIDS) is the leading cause of death among infants in the first year of age. The more known definition of SIDS is the sudden unexpected death of an infant less than 1 year of age, with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a thorough investigation, including performance of a complete autopsy and review of the circumstances of death and the clinical history. Despite the success of the “Back to Sleep” campaigns to reduce the risks introduced worldwide, the frequency of SIDS (striking one infant every 750-1,000 live births) has not significantly declined in the last years. Sudden Intrauterine Unexplained Death Syndrome (SIUDS), referring to fetuses that die unexpectedly, particularly in the last weeks of gestation, without any cause even after a complete autopsy, including examination of the placental disk, umbilical cord and fetal membranes, has a six-eightfold greater incidence than that of SIDS. Even if the pathogenetic mechanism of these deaths has not yet been determined, the neuropathology seems to be a consistent substrate in both SIUDS and SIDS. Subtle common developmental abnormalities of brainstem nuclei checking the vital functions have been highlighted, frequently related to environmental risk factors, such as cigarette smoke, air and water pollution, pesticides, food contamination, etc. Exogenous toxic factors can in fact interact in complex ways with the genetic constitution of the infant leading to polymorphisms and/or mutations of specific genes (as polymorphisms of the serotonin transporter gene 5-HTT, the regulator of the synaptic serotonin concentration, and of the PHOX2B, the key gene in the Congenital Central Hypoventilation Syndrome). These interactions can directly injure the development of the autonomic nervous system, frequently resulting in hypoplasia of the vital brainstem centers, and consequently in sudden death. It is very important to continue studying these syndromes and in particular identify all possible congenital alterations and their correlation with the exposure to environmental risk factors, in order to reduce their incidence and mitigate the surrounding social concern. The goal of this research topic is to propose new approaches to explain the pathogenesis of both SIUDS and SIDS and consequently new prevention strategies to decrease the incidence of these unexpected and very devastating events for families. Expert authors in the Topic field are encouraged to submit original research articles aimed to widen the current knowledge on the pathological substrates of these deaths, also considering the correlations with possible risk factors. Submissions of hypotheses, opinions and commentaries are also welcome. This Research Topic would lead to development of targeted risk-lowering strategies to reduce the incidence of both SIUDS and SIDS. Furthermore, the adoption of appropriate preventive measures could also lead to improve the quality of life in adults, promoting active and healthy aging.
New Approaches To The Pathogenesis Of Sudden Intrauterine Unexplained Death And Sudden Infant Death Syndrome
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Author :
language : en
Publisher:
Release Date : 2017
New Approaches To The Pathogenesis Of Sudden Intrauterine Unexplained Death And Sudden Infant Death Syndrome written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Crib Death Sudden Infant Death Syndrome Sids
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Author : Giulia Ottaviani
language : en
Publisher: Springer
Release Date : 2014-10-01
Crib Death Sudden Infant Death Syndrome Sids written by Giulia Ottaviani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-01 with Medical categories.
Crib death or sudden infant death syndrome is the most frequent death-causing syndrome during the first year of life, striking one infant in every 700-1,000. Despite a wide spectrum of theories and years of research, crib death remains a great enigma. This book describes systematic studies of the cardiovascular system and autonomic nervous system carried out in a large number of infants, newborns, and fetuses who have died suddenly and unexpectedly, as well as in age-matched control cases. The cardiovascular and neuropathological findings are presented in detail and the relationship between crib death and unexplained perinatal death is discussed. This monograph will aid pathologists, forensic pathologists, pediatricians, obstetricians and neonatologists in recognizing all potential morphological substrata. It puts forward a well-researched standardized postmortem protocol to be applied in all cases of sudden unexpected infant and perinatal death.
Infection And Inflammation Potential Triggers Of Sudden Infant Deaths
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Author : Caroline Blackwell
language : en
Publisher: Frontiers Media SA
Release Date : 2016-11-08
Infection And Inflammation Potential Triggers Of Sudden Infant Deaths written by Caroline Blackwell and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-08 with categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1996
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medicine categories.
Forensic Pathology
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Author : David Dolinak
language : en
Publisher: Elsevier
Release Date : 2005-04-08
Forensic Pathology written by David Dolinak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-08 with Law categories.
Forensic Pathology is a comprehensive reference that uses a case-oriented format to address, explain and guide the reader through the varied topics encountered by forensic pathologists. Developed in response to a severe void in the literature, the book addresses topics ranging from medicolegal investigation of death to death scene investigation, forensic autopsy, and artifacts of resuscitation as well as complications of medical therapy, forensic osteology, forensic odontology, forensic photography, and death certification. The book includes various types of cases, including sudden natural death, asphyxia, motor vehicle collisions, death in custody, child abuse and elder abuse, acute psychiatric and emotional deaths, and pregnancy. It contains sample descriptions of pathological lesions which serve to aid pathologists in reporting their findings to law enforcement agencies, attorneys, and others involved in investigations of sudden death. The concepts outlined in the text are beautifully illustrated by large, colorful photographs. There are also "Do and Don't" sections at the end of each chapter that provide guidance for handling the types of cases examined. This work will benefit not only experienced forensic pathologists, but also hospital pathologists who occasionally performs medicolegal autopsies; doctors in training; medical examiners; law enforcement personnel; crime scene investigators; attorneys; and fellows and students of the medical sciences. - Large, colorful photographs which beautifully illustrate the concepts outlined in the text. - Sample descriptions of pathological lesions which serve to aid pathologists in reporting their findings to law enforcement agencies, attorneys, and others involved in investigations of sudden death. - 'Do and Don't' sections at the end of each chapter which provide guidance for handling the types of cases examined within preceding sections.
Forensic Histopathology
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Author : Reinhard B. Dettmeyer
language : en
Publisher: Springer
Release Date : 2018-05-18
Forensic Histopathology written by Reinhard B. Dettmeyer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-18 with Medical categories.
This second edition, which combines the features of an atlas and a textbook, presents findings in forensic histology, immunohistochemistry, and cytology based on microscopic investigations using different stainings and different antibodies. Questions of quality when working in the field of forensic histology are included as well as scientific perspectives for further research. The principal aim is to provide practitioners with detailed information and guidance on how microscopy can help to clarify the cause of sudden and unexpected death. Therefore additional and particularly rare histopathological findings are presented. Many of the topics will be of interest not only to forensic pathologists but also to general pathologists, whether practitioners or researchers. Examples include the pathology of drug abuse, wound age determination, adverse drug reactions, histopathology of the sudden infant death syndrome, and age determination of myocardial infarction. Both typical and unusual findings are demonstrated with the aid of numerous high-quality color illustrations, and other key literature in forensic histology and immunohistochemistry is highlighted for each topic.
Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 1982
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Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
language : en
Publisher:
Release Date : 1981
Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 1982 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with United States categories.
Autopsy Pathology
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Author : Walter E. Finkbeiner
language : en
Publisher: Elsevier Health Sciences
Release Date : 2009-01-01
Autopsy Pathology written by Walter E. Finkbeiner and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Medical categories.
The autopsy : past and present Legal, social, and ethical issues Autopsy biosafety Basic postmortem examination Postmortem examination of fetuses and infants Special dissection procedures Autopsy photography and radiology Microscopic examination Supplemental laboratory studies The autopsy report Postmortem examination in cases of sudden death due to natural causes Postmortem examination in cases of sepsis or multiple organ dysfunction Death certification Medical quality improvement and quality assurance of the autopsy Atlas of autopsy pathology.
Sudden Death In The Young
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Author : Roger W. Byard
language : en
Publisher: Cambridge University Press
Release Date : 2010-09-16
Sudden Death In The Young written by Roger W. Byard and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-16 with Medical categories.
Determining the cause of death in children and young adults can pose considerable challenges. Professor Byard provides for the first time a complete overview of pathological aspects of sudden death in the young, from before birth to middle adult life. Highly illustrated with more than 800 colour figures, this third edition contains new sections on sexual abuse, pregnancy-related deaths and rare natural diseases, as well as expanded coverage of unexpected death in young adults up to the age of 30 years. Chapters are organised by systems and cover all aspects of natural death, as well as accidents, suicides and homicides. Supported by extensive referencing and numerous tables, the book can also be used as a practical autopsy manual. An encyclopaedic overview and analysis of sudden death in the young, this is a key text for pediatric and forensic pathologists, pediatricians, and lawyers and physicians involved in medicolegal cases.