New Drug Development For Known And Emerging Viruses
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New Drug Development For Known And Emerging Viruses
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Author : Helga Rübsamen-Schaeff
language : en
Publisher: John Wiley & Sons
Release Date : 2022-01-31
New Drug Development For Known And Emerging Viruses written by Helga Rübsamen-Schaeff and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Medical categories.
Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.
Antiviral Discovery For Highly Pathogenic Emerging Viruses
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Author : Rafael Delgado
language : en
Publisher: Royal Society of Chemistry
Release Date : 2021-12-08
Antiviral Discovery For Highly Pathogenic Emerging Viruses written by Rafael Delgado and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-08 with Medical categories.
Ideal for drug discovery scientists and medicinal chemists with an interest in antiviral drug discovery and development, this book provides a complete overview of the latest progress in the field, recent advances and the challenges that remain in developing these highly pathogenic agents.
Novel And Re Emerging Respiratory Viral Diseases
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Novel And Re Emerging Respiratory Viral Diseases written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918. Previous to this, a novel coronavirus had been identified as the aetiological agent of the severe acute respiratory syndrome (SARS), a new respiratory viral disease that emerged at the end of 2002 and caused profound disturbances in over 30 countries worldwide in 2003. It is not known whether the SARS coronavirus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. However, these outbreaks have shown that these viruses can emerge in any part of the world at any time. This book critically evaluates the latest scientific evidence on novel or re-emerging viral diseases and brings together contributions from world experts on this topic, explaining best practice in their area, and discussing lessons learned and how best to collaborate to prevent and control future outbreaks. Topics covered include: the latest advances in virology, particularly in the area of epidemiology diagnostics animal models for viral infection antiviral and vaccine development Novel and Re-emerging Respiratory Viral Diseases offers a comprehensive and interdisciplinary account of all aspects of the topic, from basic molecular biology to public health issues, and is therefore essential reading for virologists, infectious disease specialists, public health managers, researchers and epidemiologists, as well as those working in vaccine development, pharmaceutical medicine and drug discovery
Antiviral Drug Discovery And Development
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Author : Xinyong Liu
language : en
Publisher: Springer Nature
Release Date : 2021-07-13
Antiviral Drug Discovery And Development written by Xinyong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-13 with Medical categories.
This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
Antiviral Drug Discovery For Emerging Diseases And Bioterrorism Threats
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Author : Paul F. Torrence
language : en
Publisher: John Wiley & Sons
Release Date : 2005-08-05
Antiviral Drug Discovery For Emerging Diseases And Bioterrorism Threats written by Paul F. Torrence and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-05 with Medical categories.
Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.
Antiviral Discovery Against New And Emerging Viruses
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Author : Mohamad Aljofan
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2013
Antiviral Discovery Against New And Emerging Viruses written by Mohamad Aljofan and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
The preliminary objective of the work carried out in this book revolved around and took inspiration from modern drug discovery procedures. It describes the processes typically followed during 'early' drug discovery stages, including in vitro antiviral activity and preliminary cellular toxicity testing. This book presents for the first time, novel potential antiviral compounds as well as existing off-licence therapeutics capable of treating the deadly henipavirus infections. It also describes a prospective antiviral target that may permit the discovery of antiviral drugs that could significantly contribute to the management of many lethal zoonotic pathogens.
Antiviral Drug Strategies
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Author : Erik De Clercq
language : en
Publisher: Wiley-VCH
Release Date : 2011-05-16
Antiviral Drug Strategies written by Erik De Clercq and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-16 with Medical categories.
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.
Therapy Of Viral Infections
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Author : Wibke E. Diederich
language : en
Publisher: Springer
Release Date : 2016-10-17
Therapy Of Viral Infections written by Wibke E. Diederich and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-17 with Science categories.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Advances In Antiviral Research
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Author : Naveen Kumar
language : en
Publisher: Springer
Release Date : 2024-03-04
Advances In Antiviral Research written by Naveen Kumar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-04 with Medical categories.
This book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also outline approaches for designing broad-spectrum antivirals effective against viruses by epigenetic- and epitranscriptomic-targeted reprogramming. Further, it provides vital details on the procedures for drug applications, clinical trials, and their regulations. Finally, the book provides a comprehensive yet representative description of advances in antiviral research protocols and methodologies suitable for antiviral researchers at all career stages, including graduate and postgraduate students and policy-makers.
Novel And Re Emerging Respiratory Viral Diseases
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Author : Gregory R. Bock
language : en
Publisher: Wiley
Release Date : 2008-06-09
Novel And Re Emerging Respiratory Viral Diseases written by Gregory R. Bock and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-09 with Science categories.
The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918. Previous to this, a novel coronavirus had been identified as the aetiological agent of the severe acute respiratory syndrome (SARS), a new respiratory viral disease that emerged at the end of 2002 and caused profound disturbances in over 30 countries worldwide in 2003. It is not known whether the SARS coronavirus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. However, these outbreaks have shown that these viruses can emerge in any part of the world at any time. This book critically evaluates the latest scientific evidence on novel or re-emerging viral diseases and brings together contributions from world experts on this topic, explaining best practice in their area, and discussing lessons learned and how best to collaborate to prevent and control future outbreaks. Topics covered include: the latest advances in virology, particularly in the area of epidemiology diagnostics animal models for viral infection antiviral and vaccine development Novel and Re-emerging Respiratory Viral Diseases offers a comprehensive and interdisciplinary account of all aspects of the topic, from basic molecular biology to public health issues, and is therefore essential reading for virologists, infectious disease specialists, public health managers, researchers and epidemiologists, as well as those working in vaccine development, pharmaceutical medicine and drug discovery