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Therapy Of Viral Infections


Therapy Of Viral Infections
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Therapy Of Viral Infections


Therapy Of Viral Infections
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Author : Wibke E. Diederich
language : en
Publisher: Springer
Release Date : 2015-05-22

Therapy Of Viral Infections written by Wibke E. Diederich and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-22 with Science categories.


Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.



Gene Therapy For Viral Infections


Gene Therapy For Viral Infections
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Author : Patrick Arbuthnot
language : en
Publisher: Academic Press
Release Date : 2015-06-01

Gene Therapy For Viral Infections written by Patrick Arbuthnot and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Science categories.


Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field



Viral Infections And Treatment


Viral Infections And Treatment
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Author : Helga Rübsamen-Waigmann
language : en
Publisher: CRC Press
Release Date : 2003-08

Viral Infections And Treatment written by Helga Rübsamen-Waigmann and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08 with Medical categories.


Examining the pathology and transmission of the most common viral diseases, this reference compiles reviews by international specialists which detail breakthroughs in patient management, diagnostics and treatment of viral infections.



Lennette S Laboratory Diagnosis Of Viral Infections


Lennette S Laboratory Diagnosis Of Viral Infections
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Author : Keith R Jerome
language : en
Publisher: CRC Press
Release Date : 2016-04-19

Lennette S Laboratory Diagnosis Of Viral Infections written by Keith R Jerome and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.


Written from the perspective of the diagnostician, this bestselling book is the definitive text on the laboratory diagnosis of human viral diseases. It contains a wealth of illustrations, tables, and algorithms to enhance your understanding of this ever-evolving field. The book is a ready reference for virologists, microbiologists, epidemiologists, laboratorians, and infections disease specialists, and students.



New Concepts Of Antiviral Therapy


New Concepts Of Antiviral Therapy
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Author : Elke Bogner
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-31

New Concepts Of Antiviral Therapy written by Elke Bogner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-31 with Medical categories.


Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.



Antiviral Therapy


Antiviral Therapy
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Author : E. Blair
language : en
Publisher: Taylor & Francis
Release Date : 1998

Antiviral Therapy written by E. Blair and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.


A concise summary of vital information on drug targets and current therapy regimes for all of the major viral infections. The book brings together in a single volume aspects of antiviral therapy from diverse areas of research and practice, providing up-to-date coverage of recent developments. Starting from an overview of the history of antiviral chemotherapy, the book goes on to describe the development of drugs against HIV, herpesvirus, respiratory viruses, papillomaviruses and hepatitis virus infections. The drugs currently available are reviewed and possible therapies and drug targets for future prophylactic and therapeutic use are discussed.



Viral Drug Delivery Systems


Viral Drug Delivery Systems
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Author : Ranjita Shegokar
language : en
Publisher: Springer Nature
Release Date : 2023-04-10

Viral Drug Delivery Systems written by Ranjita Shegokar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-10 with Science categories.


The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems The third volume of series is focused on viral drug delivery systems. Typically, virus attaches to the cells (referred as host cell) and releases its DNA or RNA inside the cell. In second stage, virus’s genetic material takes control of the cell and forces it to replicate the virus leading to onset of disease symptoms. DNA class of viruses include Herpes, Papilloma and Adeno viruses. RNA class of viruses include retroviruses, such as HIV immunodeficiency virus and SARS COV – 2 / Corona virus. This book addresses recent developments in viral drug delivery systems. It covers many different aspects of viral infections, ways to treat them using modern drug delivery systems like nano particulate carriers. The choice of viral delivery systems mainly depends upon the type of virus, duration of life cycle, presence of drug resistance, cellular and mucosal interaction of virus, accordingly gene or non-gene drug delivery systems are selected. Besides that, this book also reports global dynamics of viral diseases, future predictions of infection rate, current treatment options, details of drug carriers like nanoemulsions, polymeric nanoparticles, role of biofunctionalization, and phyto-molecules in treatment of viral infections particularly herpes, Covid-19, Ebola, HIV/AIDS, influenza and viral hepatitis. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of viral drug delivery research.



Antiviral Therapy


Antiviral Therapy
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Author : Dr Eddie Blair
language : en
Publisher: Taylor & Francis
Release Date : 2023-05-31

Antiviral Therapy written by Dr Eddie Blair and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-31 with Science categories.


A concise summary of vital information on drug targets and current therapy regimes for all of the major viral infections. The book brings together in a single volume aspects of antiviral therapy from diverse areas of research and practice, providing up-to-date coverage of recent developments. Starting from an overview of the history of antiviral chemotherapy, the book goes on to describe the development of drugs against HIV, herpesvirus, respiratory viruses, papillomaviruses and hepatitis virus infections. The drugs currently available are reviewed and possible therapies and drug targets for future prophylactic and therapeutic use are discussed.



Exotic Viral Diseases


Exotic Viral Diseases
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Author : Stephen A. Berger
language : en
Publisher: PMPH-USA
Release Date : 2003

Exotic Viral Diseases written by Stephen A. Berger and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Diagnostic virology categories.


The world is becoming smaller, and health care workers are increasingly confronted with heretofore "exotic" and "rare" diseases contracted in or otherwise introduced from distant countries. Exotic Viral Disease: A Global Guide is written for the clinician, and deals with the epidemiology, signs, symptoms, and treatment of all unusual viral infections of man. The authors are among the leading opinion makers in the field of Geographic Medicine, and have collected a wealth of important, practical, and up-to-date information, which would otherwise be unavailable in one source to physicians. A chapter has been added to include information about SARS.



Gene Therapy For Hiv And Chronic Infections


Gene Therapy For Hiv And Chronic Infections
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Author : Ben Berkhout
language : en
Publisher: Springer
Release Date : 2015-03-10

Gene Therapy For Hiv And Chronic Infections written by Ben Berkhout and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-10 with Medical categories.


This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990’s. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.