New Factors That Affect Adrenomedullin Expression
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New Factors That Affect Adrenomedullin Expression
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Author : 黃凱健
language : en
Publisher:
Release Date : 2013
New Factors That Affect Adrenomedullin Expression written by 黃凱健 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Adrenomedullin categories.
New Factors That Affect Adrenomedullin Expression
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Author : Hoi-Kin Wong
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26
New Factors That Affect Adrenomedullin Expression written by Hoi-Kin Wong and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with categories.
This dissertation, "New Factors That Affect Adrenomedullin Expression" by Hoi-kin, Wong, 黃凱健, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: ADM is a 52-amino acid peptide which carries out multiple biological functions in cardiovascular system such as vasodilation and hypotension, and is a prognostic marker for cardiovascular diseases. Recent studies show that its plasma level is elevated in diabetes, however the reason and significance for such an increase has not been understood. Recent research has proposed that inflammation and oxidative stress both contribute to the pathogenesis of diabetes. If ADM is a marker in diabetes, it is possible that ADM is regulated by these two mechanisms, and so this project aims to investigate how these mechanisms could affect ADM expression. Recent studies have demonstrated that advanced glycation endproducts (AGEs) could lead to development of various diabetic complications. AGEs are formed as intermediate product in the non-enzymatic glycation of reducing sugars. Formation of these products is stimulated by hyperglycemia and oxidative stress, which could also induce ADM expression. Hence one of the studies investigated the direct effect of AGEs on ADM expression in an in vitro model. A rat macrophage cell line NR8383 was used to investigate the dose-response and time-point responses of macrophage cells in expressing ADM stimulated by AGEs. 6 hours of AGEs treatment resulted in no significant effect on ADM gene expression. The gene expression increased in all time points in which the change was at maximum after 1 hour of AGE treatment compared with other time points (PADM plays a role in inflammation that it could influence IL-6 and adiponectin expressions. This project also investigated whether IL-6 and adiponectin could affect ADM levels on the opposite. The associations between IL6 and adiponectin single nucleotide polymorphisms (SNPs) with plasma ADM levels were studied using a cohort of 476 subjects from the Cardiovascular Risk Factor Prevalence Study (CRISPS). Specific tagging SNPs were genotyped for the 476 subjects. Significant associations were identified for the IL6 SNP rs17147230 and adiponectin SNP rs182052 with plasma ADM levels in additive model (β=-0.096, P=0.034, and β=0.104, P=0.023 respectively adjusting for age and sex). The associations remained significant after adjusting for various covariates (PDOI: 10.5353/th_b5153742 Subjects: Oxidative stress Adrenomedullin Inflammation
Adrenomedullin
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Author : Alfredo Martínez
language : en
Publisher: IOS Press
Release Date : 1998
Adrenomedullin written by Alfredo Martínez and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Adrenomedullin categories.
Adrenomedullin is a recently discovered peptide hormone which involved in many physiological and pathological processes. This book reviews all the information available on this intriguing molecule, covering topics as diverse as blood pressure regulation, growth of tumours and normal cells, the central nervous system, and comparative studies from sharks to mammals. An international group of experts has contributed to this volume which will be of interest to professionals, researchers, and those who will benefit from a broad review of the literature and the main trends in adrenomedullin research.
The Endothelium
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Author : Michel Félétou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
The Endothelium written by Michel Félétou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Physiology Of The Gastrointestinal Tract
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Author : Kim E. Barrett
language : en
Publisher: Elsevier
Release Date : 2006-05-10
Physiology Of The Gastrointestinal Tract written by Kim E. Barrett and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-10 with Medical categories.
FROM THE PREFACE: The original purpose of the First Edition of Physiology of the Gastrointestinal Tract to collect in one set of volumes the most current and comprehensive knowledge in our field was also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan. · Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology · Information presented in a style that is both readable and understandable · Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student · Features an entirely new section on Immunology and Inflammation · Each section edited by the preeminent scientist in the field
New Research On Morbid Obesity
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Author : Wilma V. Parsons
language : en
Publisher: Nova Publishers
Release Date : 2008
New Research On Morbid Obesity written by Wilma V. Parsons and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Morbid obesity categories.
Morbid obesity, also known as clinically severe obesity, is an abnormal obesity defined as the condition of having body weight over 100 pounds over an ideal body weight or having a body mass index of 40 or higher. The term reflects the fact that this kind of obesity becomes associated with significant morbidity by increasing the risk of various obesity-related medical conditions. This book presents new and significant research in the field from around the world.
Microcirculation
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Author : Ronald F. Tuma
language : en
Publisher: Academic Press
Release Date : 2011-04-28
Microcirculation written by Ronald F. Tuma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.
Handbook Of Neuroendocrinology
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Author : George Fink
language : en
Publisher: Academic Press
Release Date : 2012
Handbook Of Neuroendocrinology written by George Fink and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
International Review Of Cytology
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Author : Kwang W. Jeon
language : en
Publisher: Elsevier
Release Date : 2002-12-05
International Review Of Cytology written by Kwang W. Jeon and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-05 with Science categories.
International Review of Cytology presents current advances and comprehensive reviews in cell biology—both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists