New Frontiers In Gene Modified T Cell Technology
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New Frontiers In Gene Modified T Cell Technology
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Author : Ignazio Caruana
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-13
New Frontiers In Gene Modified T Cell Technology written by Ignazio Caruana and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-13 with Medical categories.
The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.
Commercializing Successful Biomedical Technologies
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Author : Shreefal S. Mehta
language : en
Publisher: Cambridge University Press
Release Date : 2022-11-17
Commercializing Successful Biomedical Technologies written by Shreefal S. Mehta and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-17 with Technology & Engineering categories.
Transform your research into commercial biomedical products with this revised and updated second edition. Covering drugs, devices and diagnostics, this book provides a step-by-step introduction to the process of commercialization, and will allow you to create a realistic business plan to develop your ideas into approved biomedical technologies. This new edition includes: Over 25% new material, including practical tips on startup creation from experienced entrepreneurs. Tools for starting, growing and managing a new venture, including business planning and commercial strategy, pitching investors, and managing operations. Global real-world case studies, including emerging technologies such as regulated medical software and Artificial Intelligence (AI), offer insights into key challenges and help illustrate complex points. Tips and operational tools from established industry insiders, suitable for graduate students and new biomedical entrepreneurs.
New Frontiers And Applications Of Synthetic Biology
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Author : Vijai Singh
language : en
Publisher: Academic Press
Release Date : 2022-01-12
New Frontiers And Applications Of Synthetic Biology written by Vijai Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-12 with Science categories.
New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas. - Offers basic understanding and knowledge in several aspects of synthetic biology - Covers state-of-the-art tools and technologies of synthetic biology, including promoter design, DNA synthesis, DNA sequencing, genome design, directed evolution, protein engineering, computational tools, phage design, CRISPR-Cas systems, and more - Discusses the applications of synthetic biology for smart drugs, vaccines, therapeutics, drug discovery, self-assembled materials, cell free systems, microfluidics, and more
The International Law Of Biotechnology
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Author : Matthias Herdegen
language : en
Publisher: Edward Elgar Publishing
Release Date :
The International Law Of Biotechnology written by Matthias Herdegen and has been published by Edward Elgar Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on with Biotechnology categories.
Biotechnology is a field that inspires complex legal and ethical debates on an international scale. Taking a fresh approach to the subject, Matthias Herdegen provides a comprehensive assessment of the regulation of biotechnology processes and products from an international and comparative perspective.
Discovering Precision Health
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Author : Lloyd Minor
language : en
Publisher: John Wiley & Sons
Release Date : 2020-01-23
Discovering Precision Health written by Lloyd Minor and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-23 with Medical categories.
Today we are on the brink of a much-needed transformative moment for health care. The U.S. health care system is designed to be reactive instead of preventive. The result is diagnoses that are too late and outcomes that are far worse than our level of spending should deliver. In recent years, U.S. life expectancy has been declining. Fundamental to realizing better health, and a more effective health care system, is advancing the disruptive thinking that has spawned innovation in Silicon Valley and throughout the world. That's exactly what Stanford Medicine has done by proposing a new vision for health and health care. In Discovering Precision Health, Lloyd Minor and Matthew Rees describe a holistic approach that will set health care on the right track: keep people healthy by preventing disease before it starts and personalize the treatment of individuals precisely, based on their specific profile. With descriptions of the pioneering work undertaken at Stanford Medicine, complemented by fascinating case studies of innovations from entities including the Chan Zuckerberg Biohub, GRAIL, and Impossible Foods, Minor and Rees present a dynamic vision for the future of individual health and health care. Youll see how tools from smartphone technology to genome sequencing to routine blood tests are helping avert illness and promote health. And you'll learn about the promising progress already underway in bringing greater precision to the process of predicting, preventing, and treating a range of conditions, including allergies, mental illness, preterm birth, cancer, stroke, and autism. The book highlights how biomedical advances are dramatically improving our ability to treat and cure complex diseases, while emphasizing the need to devote more attention to social, behavioral, and environmental factors that are often the primary determinants of health. The authors explore thought-provoking topics including: The unlikely role of Google Glass in treating autism How gene editing can advance precision in treating disease What medicine can learn from aviation liHow digital tools can contribute to health and innovation Discovering Precision Health showcases entirely new ways of thinking about health and health care and can help empower us to lead healthier lives.
Introduction To Synthetic Embryology
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date :
Introduction To Synthetic Embryology written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on with Health & Fitness categories.
In the current era, in which science and technology are advancing by leaps and bounds, we are witness to discoveries and achievements that challenge us to rethink our understanding of life, health and human potential. Remarkable advances in the area of synthetic embryology and gene therapy have been the protagonists of a scientific revolution that takes us beyond the limits of what we previously imagined to be possible. In this book, we explore a vast territory of knowledge, delving into the fascinating domains of creation and modification of living beings, genetic manipulation and embryonic development. The aim is to offer the reader a panoramic and reflective view of the most recent advances in these areas, while raising crucial questions about ethical limits and the ethical and social challenges that accompany these discoveries. Throughout these pages, we delve into the development of gene therapies aimed at combating immune and muscle disorders, delving into the heart of personalized medicine and pointing to a future in which we can correct genetic defects even before birth. We also explore the frontiers between natural embryology and synthetic embryology, confronting traditional conceptions about the beginning of life and the revolutionary possibilities that arise from the manipulation of the fundamental mechanisms of embryonic development. With equal enthusiasm, we examine the applications of synthetic embryology in fields as diverse as creating transgenic foods, adapting organisms to hostile environments, understanding extraterrestrial life, and even colonizing other planets. In doing so, we are confronted with ethical and social dilemmas, the answers to which have the potential to shape not only science, but humanity itself. In each chapter, we seek to present a comprehensive and up-to-date view of scientific and technological advances, always accompanied by a critical and reflective analysis of the ethical implications and challenges we face. Our aim is to provide readers with a starting point for understanding these findings and for informed and constructive debate about the future of synthetic embryology and its implications for society. Therefore, I invite you, dear reader, to embark on this journey of discovery and reflection. As we enter this exciting, uncharted territory of synthetic embryology, we are confronted with profound and provocative questions about the nature of life, our own limits, and the responsibility we carry as custodians of science and innovation. This book is an invitation to explore the frontiers of science and ethics, to challenge our ingrained perceptions and conceptions and, above all, to ponder the future we wish to build. Embark on this journey with us and discover the intriguing and disturbing possibilities that synthetic embryology holds for us.
Gene And Cell Therapy
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Author : Nancy Smyth Templeton
language : en
Publisher: CRC Press
Release Date : 2015-01-20
Gene And Cell Therapy written by Nancy Smyth Templeton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-20 with Science categories.
The fourth edition of this bestseller presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. It continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors' research efforts as well as current technologies, disease targets, and clinical applications.
Avian Immunology
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Author : Bernd Kaspers
language : en
Publisher: Academic Press
Release Date : 2021-12-05
Avian Immunology written by Bernd Kaspers and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-05 with Technology & Engineering categories.
Avian Immunology, Third Edition contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers, include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. With contributions from the foremost international experts in the field, Avian Immunology 3rd, provides the most up-to-date crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. Avian Immunology, Third Edition, is a fascinating and growing field and surely provides new and exciting insights for mainstream immunology in the future. - Reflects significant advances in the field since the second edition, particularly the explosion of knowledge on genomics including work on the chicken, turkey and zebra finch genomes - Provides a single source reference ranging from the basic science to cutting edge research - Provides practical information for veterinarians particularly those specialised in poultry or companion bird medicine - New chapters on the impact of the microbiome on the immune system, defence mechanisms in the egg and embryo and emerging transgene technologies
Stem Cell Therapeutics
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Author : Ayush Madan
language : en
Publisher: John Wiley & Sons
Release Date : 2025-08-26
Stem Cell Therapeutics written by Ayush Madan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-26 with Science categories.
Discover the revolutionary potential of stem cell therapy and gain a comprehensive understanding of its applications, challenges, and ethical considerations across various medical fields with Stem Cell Therapeutics, a must-read for anyone interested in the future of medicine. Stem Cell Therapeutics delves into the forefront of medical research, exploring the revolutionary potential of stem cell therapy in combating a wide array of diseases. This comprehensive volume provides a thorough examination of the subject matter, offering insights into the latest advancements, methodologies, and applications of stem cell therapeutics. The book adopts a multidisciplinary approach, drawing upon expertise from fields such as biology, medicine, biotechnology, and bioengineering. Readers can expect to encounter in-depth discussions on the use of stem cells in treating various medical conditions, including neurodegenerative disorders, cardiovascular diseases, autoimmune conditions, and cancer. Each chapter provides a comprehensive overview of the current state of research for each disease, highlighting the challenges, successes, and prospects of stem cell-based therapies. Additionally, the book explores ethical considerations, regulatory frameworks, and commercialization strategies surrounding the field, ensuring a well-rounded understanding of the subject matter for readers at all levels of expertise.
Principles Of Pharmaceutical Biotechnology
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Author : Abhinav Talwar
language : en
Publisher: Educohack Press
Release Date : 2025-02-20
Principles Of Pharmaceutical Biotechnology written by Abhinav Talwar and has been published by Educohack Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-20 with Health & Fitness categories.
"Principles of Pharmaceutical Biotechnology" delves into the world of biopharmaceuticals, medicinal products derived from living organisms. We provide a comprehensive overview, explaining the science behind biopharmaceuticals and their production. Topics include protein engineering, gene cloning, and purification, with complex concepts clarified through examples. Readers will learn about the latest advancements in this field, including gene editing and next-generation sequencing, and explore real-world examples of how biopharmaceuticals are transforming healthcare. We also address the complexities, covering regulations, ethical considerations, and challenges surrounding biopharmaceuticals. Insights into drug approval processes and the ethical aspects of gene editing are provided. This book is a valuable resource for students and healthcare professionals, offering a strong foundation in the science and exploring the future of this transformative field.