New Horizons In Platelet Activating Factor Research
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New Horizons In Platelet Activating Factor Research
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Author : C. M. Winslow
language : en
Publisher: John Wiley & Sons
Release Date : 1987
New Horizons In Platelet Activating Factor Research written by C. M. Winslow and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
Platelet Activating Factor (PAF) is a naturally occurring substance with potent biological effects which have a broad significant role in the activation of various inflammatory cells. It therefore contributes to a number of serious clinical conditions including anaphylaxis, allergic and inflammatory diseases (eg. asthma, rhinitis, thrombosis). This book brings together leading investigators in the field to present their latest research directed towards the biosynthesis of PAF, its cellular origins, PAF induced cellular and tissue responses, pathophysiological responses and, most important, to finding effective antagonistic drugs to control this inflammatory mediator.
Platelet Activating Factor And Related Lipid Mediators
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Author : F. Snyder
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Platelet Activating Factor And Related Lipid Mediators written by F. Snyder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Platelet-activating factor (PAF) is the commonly used name for a group of potent biologically active, ether-linked phospholipids, the alkylacetylglycerophospho cholines. Following the identification of the chemical structure of P AF in 1979, much progress has been made in our understanding of these phospholipid medi ators. This is particularly true from the points of view of their molecular structural requirements for expression of biological activity, their biosynthesis and cata bolism, their diverse range of biological activities, evidence for their specific recep tors at the cell surface, the development of specific antagonists for use in receptor studies and for testing as potential anti-PAF drugs, and implications about their involvement in health and disease. Chapters in this book cover the current status of these general areas of PAF research. Although an enormous amount of information has been published about this interesting new type of phospholipid mediators, questions about their mechanism of action, regulatory controls, and the precise role and relative importance of P AF in specific diseases and physiological functions remain to be answered. Since the 1979 discovery, the PAF field has brought together scientists from a variety of different biomedical disciplines. The diversity of scientists now in PAF research is very apparent from the number of P AF publications appearing in a wide array of scientific journals, ranging from molecular biology to clinical medicine. Publications related to PAF continue to increase at an amazingly rapid rate, with the pace reminiscent of the period following the discovery of prostaglandins.
Handbook Of Paf And Paf Antagonists
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Author : lPierre Braquet
language : en
Publisher: CRC Press
Release Date : 2019-06-13
Handbook Of Paf And Paf Antagonists written by lPierre Braquet and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-13 with Medical categories.
Published in 1991: Since its characterization in the 1970s from antigen-stimulated rabbit basophils, platelet-activating factor (PAF) has been demonstrated to be produced by, and act upon, a variety of cell types. PAF antagonists, which have been obtained from both natural sources and chemical synthesis, now represent a new class of therapeutic agents and may provide new prospects for treating several major pathologies, particularly shock, ischemia and asthma. This book provides a unique overview of the chemistry, molecular modeling, pharmacology, and clinical potential of the major classes of natural and synthetic PAF antagonists. Compounds reviewed include the ginkgolides, diketopiperazines, neolignans, hetrazepines, cyclic and 1,3-dioxolan derived PAF analogs, pyrrolo[1,2-c]thiazoles, imidazo[2,1-a]isoquinolines and pyridoquinazoline carboxamides. Consisting of 12 chapters written by leading experts in PAF antagonist research, this book is essential reading for students, researchers, clinicians, and medical practitioners involved in this rapidly developing field of biomedical research.
Handbook Of Mucosal Immunology
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Handbook Of Mucosal Immunology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae.The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physiology of mucosal defense. It discusses such topics as the structure and function of themucosal epithelium, characteristics of mucosal-associated lymphoid tissue (MALT), Peyers patches, and concepts of mucosal vaccines. The second section focuses on the secretory immune system with special reference to mucosal diseases in the digestive (GALT), respiratory (BALT), and genitourinary tracts. This information is especially important in light of the current interest in the mechanisms, transmission, and prevention of infectious diseases such as AIDS, hepatitis, and tuberculosis.Virtually all chapters have been authored by the original investigators responsible for key observations on which current concepts are based. This handbook will be an invaluable resource for a diverse group of both researchers and practicing clinicians.Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology will all find this handbook the most complete work on the subject.
Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date :
Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medicine categories.
First multi-year cumulation covers six years: 1965-70.
National Library Of Medicine Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date : 1987
National Library Of Medicine Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medicine categories.
Environmental Health Perspectives
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Author :
language : en
Publisher:
Release Date : 1993
Environmental Health Perspectives written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Environmental health categories.
Emerging Strategies In Neuroprotection
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Author : Manangos
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Emerging Strategies In Neuroprotection written by Manangos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
SOLOMON H. SNYDER Receptor Research Reaches Neurology: Relevance to Neurodegenerative Diseases and Stroke President George Bush has heralded the 1990s as the decade of the brain, based largely on the rapid escalation of advances in the molecular neuro sciences and the likelihood that these will bear therapeutic fruit before the turn of the century. There is little doubt that the 1970s and 1980s have witnessed more remarkable advances in the molecular neurosciences than all of the preceding hundred years. Identification of receptor sites for drugs and neurotransmitters along with simple, sensitive, and specific means of monitoring them has made it possible to elucidate the mechanism of action for many known drugs and to identify new chemical entities as potential therapeutic agents. At the same time, the numbers of distinct neurotrans mitters have multiplied. Prior to 1970 only the biogenic amines were well accepted as transmitters. The early 1970s witnessed the gradual acceptance of amino acids as major excitatory and inhibitory neurotransmitters. Identification of opiate receptors and the subsequent identification of the enkephalins as their endogenous ligands led to an appreciation of peptides as putative transmitters and the accumulation of as many as a hundred neuropeptides by the decade's end. In the 1980s the revolutions of molecular biology have been applied aggressively to the neurosciences with molecular cloning for neuropeptide precursors, many important neurochemical en zymes, and receptors for numerous transmitters.
Reviews In Environmental Health 1996 Indices Volume 103 Supplements 1 9
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Author :
language : en
Publisher:
Release Date : 1996
Reviews In Environmental Health 1996 Indices Volume 103 Supplements 1 9 written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Environmental health categories.
Organic Dusts Exposure Effects And Prevention
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Author : Ragnar Rylander
language : en
Publisher: CRC Press
Release Date : 1994-06-08
Organic Dusts Exposure Effects And Prevention written by Ragnar Rylander and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-08 with Technology & Engineering categories.
Organic dusts are particles of vegetable, animal, and microbial origin and are found in a wide range of occupational and general environments. This comprehensive handbook discusses organic dusts and their effects on man. Organic Dusts describes the different environments in which organic dusts are present; it also explains the major components of dusts and which diseases they can induce after inhalation. The first book to completely cover this important environmental exposure, this valuable reference presents a systematic approach to disease pathology and offers revised terminology for diagnosis based on the latest information on cell reactions and the functioning of the immune system.