New Insights Into And Interventions Of The Persistent Immune Responses In Chronic Graft Rejection 2nd Edition
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New Insights Into And Interventions Of The Persistent Immune Responses In Chronic Graft Rejection 2nd Edition
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Author : Hao Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09
New Insights Into And Interventions Of The Persistent Immune Responses In Chronic Graft Rejection 2nd Edition written by Hao Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.
Publisher’s note: This is a 2nd edition due to an article retraction.
From Portal Hypertension To Acute On Chronic Liver Failure New Insights To Pathophysiology And Management Of Liver Cirrhosis
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Author : Michael Praktiknjo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-07
From Portal Hypertension To Acute On Chronic Liver Failure New Insights To Pathophysiology And Management Of Liver Cirrhosis written by Michael Praktiknjo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Medical categories.
Acute On Chronic Liver Failure Systemic Inflammation And Immunosuppression 2nd Edition
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Author : Yu Shi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-29
Acute On Chronic Liver Failure Systemic Inflammation And Immunosuppression 2nd Edition written by Yu Shi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-29 with Medical categories.
Acute-on-chronic liver failure (ACLF) is a fatal disease that develops in the basis of chronic liver diseases due to acute precipitating events. The lack of definite therapies for ACLF other than liver transplantation urges us to investigate its pathophysiological mechanism. It has been recognized that systemic inflammation is a major driver of ACLF. Although the link between systemic inflammation and organ failure has been established, less is known about how systemic inflammation forms and how it impacts on the organ functions. On the other hand, immunosuppression is another facet of immune derangement of ACLF, which leads to secondary bacterial infections and worsens the situation. However, so far, we know very little on the development of immunosuppression during ACLF and its molecular mechanisms. Thus, this disease is still a big challenge to both clinicians and researchers. The immune derangement of ACLF is characterized by systemic inflammation and immunosuppression. Therefore, one aspect of this Research Topics is to define the concept of systemic inflammation in the context of ACLF. We should clarify the anatomy of systemic inflammation, including the inducers (DAMP and PAMP), immune cells, cytokines and other elements, and their specific roles. We should also investigate how systemic inflammation impacts on organ function and thereby precipitates the development of organ failure. The other aspect of this Research Topic is to delineate immunosuppression in ACLF. Likewise, we need to define immunosuppression by elucidating its causative mechanisms and uncover the specific stage of ACLF at which immunosuppression occurs. Besides, it is essential to further evaluate the impact of immunosuppression on the progression of ACLF. The investigation at these two facets of immune derangement of ACLF will lead to the discovery of biomarkers and potential therapeutical targets.
New Insights On Liver Transplant And Tolerance
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Author : Xiao-Kang Li
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-24
New Insights On Liver Transplant And Tolerance written by Xiao-Kang Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1977
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Medicine categories.
Immunological Challenges Following Pediatric Hematopoietic Transplantation
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Author : Robert James Hayashi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-28
Immunological Challenges Following Pediatric Hematopoietic Transplantation written by Robert James Hayashi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-28 with Medical categories.
Recent Advances In The Understanding Of Hepatocellular Carcinogenesis 2nd Edition
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Author : Prasanna K. Santhekadur
language : en
Publisher: Frontiers Media SA
Release Date : 2024-09-19
Recent Advances In The Understanding Of Hepatocellular Carcinogenesis 2nd Edition written by Prasanna K. Santhekadur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-19 with Science categories.
Hepatocellular carcinoma (HCC) is the most common cancer of the liver and the third most cause of cancer-related deaths worldwide. The 5-year survival of HCC is less than 20%, making HCC the second most lethal malignancy; the first being pancreatic cancer. HCC usually occurs in patients with chronic liver disease in association with a variety of risk factors, including chronic liver infection with hepatitis B virus or hepatitis C virus; excessive consumption of alcohol; overeating, obesity, and nonalcoholic fatty liver disease; other metabolic liver diseases including Wilson’s disease, hemochromatosis, and alpha-1-antitrypsin deficiency; and environmental toxins such as aflatoxins. Tobacco use and human immunodeficiency virus infection also increases the risk of HCC. The heterogeneity of HCC associated with different etiologies affects tumor initiation, development and progression, thus limiting the identification of consistent or routinely occurring genetic abnormalities characteristic of this malignancy. Nevertheless, sustained inflammation, hepatocyte regeneration, and apoptosis occurring in chronic liver disease results in fibrosis and ultimately cirrhosis, favoring genetic and epigenetic modifications that lead to the formation of dysplastic nodules and eventually oncogenesis. Identification of novel diagnostic and prognostic biomarkers for HCC is an unmet need in this current era. The aim of this Research Topic is to provide insights on novel aspects of HCC diagnosis, prognostication, and therapy with an emphasis on recent and up-to-date findings from the scientific literature. Genetic and molecular signatures arising from HCC in association with specific etiologies, and implications for cancer screening and surveillance will be discussed. As indicated sub-topics listed below, Original articles, Reviews and Mini-Review articles will address all areas of HCC relevant not only to basic and clinical researchers but also to practitioners in various fields of medicine: 1) Epidemiology of Hepatocellular carcinoma 2) Risk factors for hepatocellular carcinoma 3) Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma 4) Animal models for studying hepatocellular carcinoma 5) Hepatocellular Carcinoma Oncogenes 6) Tumor suppressors and Novel regulators of Hepatocellular Carcinoma 7) MicroRNA and Hepatocellular Carcinoma 8) Circulating biomarkers of Hepatocellular Carcinoma
Principles Of Tissue Engineering
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Author : Robert Lanza
language : en
Publisher: Academic Press
Release Date : 2011-10-13
Principles Of Tissue Engineering written by Robert Lanza and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-13 with Science categories.
First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.New to this edition:*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems
Chronic Graft Versus Host Disease
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Author : Georgia B. Vogelsang
language : en
Publisher: Cambridge University Press
Release Date : 2009-04-20
Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-20 with Medical categories.
Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Ctla 4 In Autoimmune Disease
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Author : Flemming Pociot
language : en
Publisher:
Release Date : 2004
Ctla 4 In Autoimmune Disease written by Flemming Pociot and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.