New Insights Into Heme Peroxidases
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New Insights Into Heme Peroxidases
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Author : Andrea Gumiero
language : en
Publisher:
Release Date : 2011
New Insights Into Heme Peroxidases written by Andrea Gumiero and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Heme peroxidises catalyse the H2O2-dependent oxidation of substrates in a two-step process, through formation of two oxy-ferryl intermediates known as Compound I and Compound II. Despite the considerable effort worldwide, important aspects about the reactivity of these enzymes are still to be clarified. Amongst all, the determination of the nature of the Fe-O bond in the oxy-ferryl intermediates, as well as the mechanism by which protons are delivered to the oxy-ferryl species during turnover, are of highest relevance. In this thesis, high resolution crystal structures of both Compound I and Compound II intermediates in two heme peroxidases, cytochrome c peroxidase (CcP) and ascorbate peroxidase (APX), are presented. In order to rule out the photoreduction arising from X-ray exposure during data collection, which causes alteration of ferryl intermediate structures, a multicrystal method has been employed. Results indicate that Compound I, with an Fe-O distance of 1.63 Å for CcP and 1.73 Å for APX, is consistent with an unprotonated oxy-ferryl species (FeIV-OH), whereas Compound II, with an Fe-O bond length of 1.83 Å and 1.84 Å for CcP and APX respectively, is consistent with a protonated oxy-ferryl species (FeIV-OH). Also presented in this thesis is the 2.40 Å structure of resting ferric CcP at room temperature obtained, for the first time, by neutron crystallography. This study allowed to establish the location of individual, exchangeable hydrogen atoms thus revealing the protonation states of several key active site residues in the distal (Arg48, Trp51, His52) and proximal (His163, Trp191, Asp235) heme regions. This information was used to revise the reaction mechanism of heme peroxidases and also to infer a possible delivery pathway of protons during turnover. All together, these data not only clarify long-standing inconsistencies on the nature of the oxy-ferryl species, but they also provide new insights into the reaction mechanism of heme peroxidases and provide important information which may apply to other categories of heme enzymes such as the cytochromes P450 and NO synthases.
New Insights Into Heme Peroxisases
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Author : Andrea Gumiero
language : en
Publisher:
Release Date : 2011
New Insights Into Heme Peroxisases written by Andrea Gumiero and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Biocatalysis Based On Heme Peroxidases
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Author : Eduardo Torres
language : en
Publisher: Springer
Release Date : 2010-09-01
Biocatalysis Based On Heme Peroxidases written by Eduardo Torres and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-01 with Science categories.
The last systematic description of heme peroxidases was published in 1999 by Brian Dunford, from the University of Alberta in Canada. The book Heme per- idases covers discussion on three-dimensional structure, reaction mechanism, kinetics, and spectral properties of representative enzymes from bacterial, plant, fungal, and animal origin. Since 1999, vast information on basic but also applied aspects of heme peroxidases has been generated. We believe fusion of these two aspects will bene?t research of those dedicated to development of biocatalytic process. The aim of this book is to present recent advances on basic aspects such as evolution, structure–function relation, and catalytic mechanism, as well as applied aspects, such as bioreactor and protein engineering, in order to provide the tools for rational design of enhanced biocatalysts and biocatalytic processes. The book does not include an exhaustive listing of references but rather a selected collection to enrich discussion and to allow envisioning future directions for research. This book is organized in three parts. In Part I, current knowledge of structure and mechanism of peroxidases is covered. From the molecular phylogeny, going through the in?uence of structural factors over oxidative ability to the molecular mechanism of catalysis, the authors intend to provide an understanding of per- idases at the molecular level. The understanding of the fundamental behavior of peroxidases will allow further adequation, design, and/or optimization of pero- dase-based catalysis to a particular process. In Part II, research on potential applications of peroxidases in several ?elds is presented and discussed.
Heme Peroxidases
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Author : Emma Raven
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-10-26
Heme Peroxidases written by Emma Raven and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-26 with Science categories.
Heme peroxidases are widely distributed in biological systems and are involved in a wide range of processes essential for life. This book provides a comprehensive single source of information on the various aspects of heme peroxidase structure, function and mechanism of action. Chapters written and edited by worldwide experts span a range of heme peroxidases from plants, yeast, bacteria and mammals. Discussed functions of peroxidases range from cell wall synthesis, synthesis of prostaglandins, role in drug suppression of tuberculosis, and antibacterial activity. Included is a discussion of peroxidases that also act as catalases and oxygenases. Heme Peroxidases serves as an essential text for those working in industry and academia in biochemistry and metallobiology.
Biocatalysis Based On Heme Peroxidases
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Author : Eduardo Torres
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-20
Biocatalysis Based On Heme Peroxidases written by Eduardo Torres and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-20 with Science categories.
The last systematic description of heme peroxidases was published in 1999 by Brian Dunford, from the University of Alberta in Canada. The book Heme per- idases covers discussion on three-dimensional structure, reaction mechanism, kinetics, and spectral properties of representative enzymes from bacterial, plant, fungal, and animal origin. Since 1999, vast information on basic but also applied aspects of heme peroxidases has been generated. We believe fusion of these two aspects will bene?t research of those dedicated to development of biocatalytic process. The aim of this book is to present recent advances on basic aspects such as evolution, structure–function relation, and catalytic mechanism, as well as applied aspects, such as bioreactor and protein engineering, in order to provide the tools for rational design of enhanced biocatalysts and biocatalytic processes. The book does not include an exhaustive listing of references but rather a selected collection to enrich discussion and to allow envisioning future directions for research. This book is organized in three parts. In Part I, current knowledge of structure and mechanism of peroxidases is covered. From the molecular phylogeny, going through the in?uence of structural factors over oxidative ability to the molecular mechanism of catalysis, the authors intend to provide an understanding of per- idases at the molecular level. The understanding of the fundamental behavior of peroxidases will allow further adequation, design, and/or optimization of pero- dase-based catalysis to a particular process. In Part II, research on potential applications of peroxidases in several ?elds is presented and discussed.
Tuberculosis New Insights For The Healthcare Professional 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-10
Tuberculosis New Insights For The Healthcare Professional 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-10 with Medical categories.
Tuberculosis: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Tuberculosis. The editors have built Tuberculosis: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Tuberculosis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Tuberculosis: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Brain Hypoxia And Ischemia New Insights Into Neurodegeneration And Neuroprotection
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Author : Natalia N Nalivaeva
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-15
Brain Hypoxia And Ischemia New Insights Into Neurodegeneration And Neuroprotection written by Natalia N Nalivaeva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-15 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
New Insights Into Membrane Science And Technology Polymeric And Biofunctional Membranes
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Author : Dibakar Bhattacharyya
language : en
Publisher: Elsevier
Release Date : 2003-05-23
New Insights Into Membrane Science And Technology Polymeric And Biofunctional Membranes written by Dibakar Bhattacharyya and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-23 with Business & Economics categories.
Membrane techniques provide a broad science and technology base. Although there are several books in the traditional membrane field, there is a great need for a highly comprehensive book. This refereed book covers materials from highly respected researchers. This title is highly multidisciplinary in nature and should be extremely valuable to scientists and engineers involved in a variety of activities. Students and faculty members around the world will find this title to be an excellent reference book. Invited contributions from leading researchers in the field Coverage of topic is of value to scientists/engineers working in a variety of related fields [separations/reactions, advanced biofunctional materials, contactor designs] Aims to fill market gap for a highly comprehensive book containing advances in both synthetic and biofunctional/bimimetic membranes
Peroxidases And Catalases
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Author : H. Brian Dunford
language : en
Publisher: John Wiley & Sons
Release Date : 2010-03-15
Peroxidases And Catalases written by H. Brian Dunford and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-15 with Science categories.
SINGLE SOURCE GUIDE TO PEROXIDASES AND CATALASES Reflecting the important historical discoveries and exciting research in the field in recent years, Peroxidases and Catalases: Biochemistry, Biophysics, Biotechnology and Physiology provides a much-needed systematic, up-to-date treatment of peroxidases and catalases. From the structure and properties of the various superfamilies to current applications of peroxidases, the book consolidates vast amounts of information previously scattered in the professional literature, covering all aspects of these ubiquitous enzymes that act on a variety of substances and processes in living systems—their properties, reactions, crystal structures, cloning, and more. Considering the subject from both theoretical and applied perspectives, Peroxidases and Catalases offers a critical review of the literature and detailed discussions of the most current research. Chapters cover: The background and history of peroxidases and catalases Plant, fungal, and bacterial peroxidase superfamilies and their organization Mammalian peroxidases including medical and physiological roles Spectroscopic and theoretical techniques for studying peroxidases highlighting the contributions of physicists and physical/theoretical chemists Heme peroxidases, catalases, and other peroxidases such as vanadium and selenium peroxidase Relevant plant and animal physiology This one-stop reference is a vital reference for biochemists, biologists, biochemical engineers, physiologists, environmental and pharmaceutical researchers, and others interested in the study and use of peroxidases and catalases.
Advances In Microbial Physiology
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-10-20
Advances In Microbial Physiology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-20 with Science categories.
Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, it is now in its 50th volume. The Editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to “traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series. In 2004, the Institute for Scientific Information released figures showing that the series had an Impact Factor of 8.947, with a half-life of 6.3 years, placing it 5th in the highly competitive category of Microbiology