Brain Hypoxia And Ischemia New Insights Into Neurodegeneration And Neuroprotection
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Brain Hypoxia And Ischemia New Insights Into Neurodegeneration And Neuroprotection
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Author : Natalia N Nalivaeva
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-15
Brain Hypoxia And Ischemia New Insights Into Neurodegeneration And Neuroprotection written by Natalia N Nalivaeva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-15 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Cerebrovascular And Neurodegenerative Diseases New Insights Into Molecular Cell Biology And Therapeutic Targets
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Author : Sikha Saha
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-30
Cerebrovascular And Neurodegenerative Diseases New Insights Into Molecular Cell Biology And Therapeutic Targets written by Sikha Saha and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-30 with categories.
Emerging Strategies In Neuroprotection
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Author : Manangos
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Emerging Strategies In Neuroprotection written by Manangos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Social Science categories.
SOLOMON H. SNYDER Receptor Research Reaches Neurology: Relevance to Neurodegenerative Diseases and Stroke President George Bush has heralded the 1990s as the decade of the brain, based largely on the rapid escalation of advances in the molecular neuro sciences and the likelihood that these will bear therapeutic fruit before the turn of the century. There is little doubt that the 1970s and 1980s have witnessed more remarkable advances in the molecular neurosciences than all of the preceding hundred years. Identification of receptor sites for drugs and neurotransmitters along with simple, sensitive, and specific means of monitoring them has made it possible to elucidate the mechanism of action for many known drugs and to identify new chemical entities as potential therapeutic agents. At the same time, the numbers of distinct neurotrans mitters have multiplied. Prior to 1970 only the biogenic amines were well accepted as transmitters. The early 1970s witnessed the gradual acceptance ofamino acids as major excitatory and inhibitory neurotransmitters. Identification of opiate receptors and the subsequent identification of the enkephalins as their endogenous ligands led to an appreciation of peptides as putative transmitters and the accumulation of as many as a hundred neuropeptides by the decade's end. In the 1980s the revolutions of molecular biology have been applied aggressively to the neurosciences with molecular cloning for neuropeptide precursors, many important neurochemical en zymes, and receptors for numerous transmitters.
Neuro Inflammation In Neuronal Death And Repair
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Author : Stuart Lipton
language : en
Publisher: Elsevier
Release Date : 2007-07-25
Neuro Inflammation In Neuronal Death And Repair written by Stuart Lipton and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-25 with Medical categories.
Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is needed to understand the role of neuroinflammatory mediators and processes in these conditions. This volume brings together renowned, international scientists to discuss current knowledge and views on the mechanisms of neuroinflammation, on its role in the context of different neurodegenerative diseases (i.e. Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis, pain) and on the potential approaches for future therapeutic strategies.
Neonatal Hematology And Transfusion Medicine An Issue Of Clinics In Perinatology
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Author : Robert D. Christensen
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-11-12
Neonatal Hematology And Transfusion Medicine An Issue Of Clinics In Perinatology written by Robert D. Christensen and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-12 with Medical categories.
Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases
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Author : Pukar Khanal
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-02
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases written by Pukar Khanal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-02 with Science categories.
Neurodegenerative disorders have increasing incidence with limited treatment options. Approaches to target neuroinflammation in various neurodegenerative disorders, such as Alzheimer’s disease (AD), involve a quest for innovative therapeutics. A comprehensive understanding of the quest for small compounds that improve amyloid processing, regulate autophagy, hinder Aß accumulation, and investigate the array of phytochemicals present in naturally occurring nootropics (ethnomedicines) and polypharmacology may facilitate the exploration of diverse pharmacological approaches to impede disease advancement. Galantamine from snowdrops (Galanthus spp.) is just one example of a current core medication used in the management of cognitive decline, pointing to the potential of small molecules in this context. In addition, the combinations of computational and experimental pharmacological methods enable the exploration of small molecules within crucial neurodegenerative processes, which can help to develop potential therapeutic compounds.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Central Nervous System Acting Drugs Molecular Mechanisms Of Neuroprotection And Neurodegeneration
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Author : Nesrine Salah El Dine El Sayed
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-14
Central Nervous System Acting Drugs Molecular Mechanisms Of Neuroprotection And Neurodegeneration written by Nesrine Salah El Dine El Sayed and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-14 with Science categories.
New Concepts In Cerebral Ischemia
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Author : Rick C. S. Lin
language : en
Publisher: CRC Press
Release Date : 2001-12-21
New Concepts In Cerebral Ischemia written by Rick C. S. Lin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-12-21 with Medical categories.
Approximately half a million Americans suffer brain ischemic episodes every year. These brain strokes are the third leading cause of death in the United States and the number-one cause of permanent disability. Over the past decade, we have made extensive attempts to understand the biological mechanisms that underlie stroke-induced neuronal injury. Providing a detailed description of the techniques and theories employed in both basic and clinical research, New Concepts in Cerebral Ischemia delineates the mechanisms underlying neuronal damage induced by ischemia. The book covers methods to elucidate the pathogenesis of ischemia, technologies used in the design of specific strategies to protect neurons from further injury, and new approaches to treat patients with acute ischemic episodes. It includes methods and therapeutic approaches for neuronal protection against acute and chronic ischemic episodes and describes new animal models for ischemia research including the application of transgenic animals.
1724 2024 3
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Author : Аркадий Мелуа
language : ru
Publisher: Litres
Release Date : 2024-07-22
1724 2024 3 written by Аркадий Мелуа and has been published by Litres this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-22 with Biography & Autobiography categories.
Отделения медицинских наук и физиологических наук являются частью Российской Академии наук. Академия наук в России (РАН) была создана в 1724 г. в начале Эпохи Просвещения. В других странах были созданы Национальная Академия деи Линчеи (1603), Германская Академия естествоиспытателей «Леопольдина» (1652), Лондонское Королевское общество по развитию знаний о природе (1660), Французская Академия наук (1666), Шведская Королевская Академия наук (1739), Королевская Шведская Академия словесности, истории и древностей (1753), Туринская Академия наук (1757), Баварская Академия наук (1759), Шведская Академия (1786) и другие. За 300 лет истории РАН ее членами стали около 8000 граждан России и других стран; в настоящее время ее членами являются около 2500 ученых. Число членов РАН превышает численность Германской Академии естествоиспытателей «Леопольдина». Более 3000 членов РАН являются учеными из других стран или тесно сотрудничают с научными учреждениями других стран. Значительное число лауреатов Нобелевских премий стали членами РАН. По представительности иностранных ученых РАН, Французская Академия наук и Шведская Королевская Академия наук занимают ведущие позиции в истории европейской науки.Биографическая энциклопедия «Медики, члены отделений медицинских наук, физиологических наук и смежных специальностей РАН» составлена на основе выпускаемой с 2018 г. многотомной биографической энциклопедии «Академия наук. Биографии» и включает статьи обо всех действительных членах, членах-корреспондентах, почётных членах и иностранных членах этих Отделений и учёных других отделений, чья деятельность в 1724—2024 гг. посвящена решению актуальных для медицинских наук и здравоохранения научных проблем. Некоторые биографические статьи дополнены фрагментами текстов оригинальных научных работ, относящихся к наследию учёного.