Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases
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Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases
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Author : Pukar Khanal
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-02
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases written by Pukar Khanal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-02 with Science categories.
Neurodegenerative disorders have increasing incidence with limited treatment options. Approaches to target neuroinflammation in various neurodegenerative disorders, such as Alzheimer’s disease (AD), involve a quest for innovative therapeutics. A comprehensive understanding of the quest for small compounds that improve amyloid processing, regulate autophagy, hinder Aß accumulation, and investigate the array of phytochemicals present in naturally occurring nootropics (ethnomedicines) and polypharmacology may facilitate the exploration of diverse pharmacological approaches to impede disease advancement. Galantamine from snowdrops (Galanthus spp.) is just one example of a current core medication used in the management of cognitive decline, pointing to the potential of small molecules in this context. In addition, the combinations of computational and experimental pharmacological methods enable the exploration of small molecules within crucial neurodegenerative processes, which can help to develop potential therapeutic compounds.
Novel Therapeutic Mechanisms Targeting Neuro Immune Regulation Of Neurological Disorders
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Author : Xin Luo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-04
Novel Therapeutic Mechanisms Targeting Neuro Immune Regulation Of Neurological Disorders written by Xin Luo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-04 with Science categories.
Novel Therapeutic Target And Drug Development In Neurovascular Retinal Diseases
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Author : Amy Cheuk Yin Lo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-08
Novel Therapeutic Target And Drug Development In Neurovascular Retinal Diseases written by Amy Cheuk Yin Lo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-08 with Science categories.
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments
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Author : Mariela Fernanda Perez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-20
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments written by Mariela Fernanda Perez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-20 with Science categories.
Neuroprotection In Alzheimer S Disease
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Author : Illana Gozes
language : en
Publisher: Academic Press
Release Date : 2017-01-18
Neuroprotection In Alzheimer S Disease written by Illana Gozes and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-18 with Psychology categories.
Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics.
Neurology 14
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date : 2025-05-02
Neurology 14 written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-02 with Medical categories.
The brain remains one of the greatest frontiers of human knowledge, captivating scientists, clinicians, and philosophers alike. In recent decades, monumental strides in neuroscience have redefined our understanding of the nervous system—from molecular signaling pathways to complex behavioral manifestations. This book is born from the collective progress of these explorations, offering a comprehensive dive into both the theoretical framework and practical applications emerging from neuroscience research. Each chapter has been carefully curated to bridge the gap between foundational knowledge and cutting-edge innovation. While exploring synaptogenesis, neurogenomics, and gene therapies, the book also highlights the critical importance of interdisciplinary collaborations that fuse biology, engineering, and medicine. The result is a resource that speaks not only to scholars and healthcare professionals but also to engineers, biotechnologists, and students looking to grasp the intricacies of the nervous system. As science pushes forward into previously uncharted territories like epigenetics, nanoneurosurgery, and cognitive rehabilitation, we must ensure that knowledge dissemination keeps pace. This preface is both an invitation and a responsibility—to inspire curiosity, support learning, and ultimately foster breakthroughs in the prevention, diagnosis, and treatment of neurological disorders.
Exploring Molecular Targets To Treat Neurodegenerative Disorders
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Author : Prashant Tiwari
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2024-05-01
Exploring Molecular Targets To Treat Neurodegenerative Disorders written by Prashant Tiwari and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-01 with Medical categories.
This book delves into the delicate realm of neurodegenerative illnesses, navigating the vast landscape of molecular targets with care and purpose. Researchers are studying the complex pathways involved in diseases such as Alzheimer’s, Parkinson’s, and Huntington’s in order to identify specific molecules that could be targeted for therapy. The present work explores potential methods of intervention by carefully analysing neural circuits, protein misfolding, and genetic predispositions, unravelling the complexities of the human mind by focusing on individual molecular targets. As new findings emerge, reducing the severe consequences of neurodegenerative illnesses becomes increasingly possible, providing optimism for millions of people throughout the world.
Neurodegenerative Diseases
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Author : Nagehan Ersoy Tunalı
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-01-20
Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.
Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.
Redox Signaling In Neurodegenerative Diseases Biomarkers Targets And Therapies
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Author : Andreia Neves Carvalho
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-16
Redox Signaling In Neurodegenerative Diseases Biomarkers Targets And Therapies written by Andreia Neves Carvalho and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-16 with Science categories.
Redox homeostasis results from the balance between the production of reactive species (e.g. ROS, RNS, etc) and their detoxification by endogenous or exogenous antioxidants. ROS play several important physiological roles, however, their excessive production or impaired detoxification is associated with oxidative stress and cellular injury. Importantly, oxidative damage to vulnerable central nervous system (CNS) cells is a common pathological feature of several neurodegenerative diseases. Antioxidants have been considered as attractive potential therapeutic agents to prevent or halt disease progression but the clinical efficacy of antioxidant treatment strategies is still marginal. Improvement of antioxidant therapy effectiveness might involve adjustment of preclinical to clinical settings and development of new efficient delivery methods and will require a more in-depth knowledge of cellular redox-signaling mechanisms. Promising novel redox-based therapeutic strategies are gaining relevance to combat oxidative stress associated with neurodegenerative diseases. These include boosting the endogenous antioxidant machinery through activation of the antioxidant master regulator Nrf2 (nuclear factor erythroid 2-related factor 2) or modulation of ROS production by NOX (nicotinamide adenine dinucleotide phosphate (NADPH) oxidase) inhibitors. Redox regulation of key cellular functions is currently recognized as an important cellular signaling mechanism and events such as post-translational modifications (e.g. S_glutathionylation, S_nitrosylation, glycosylation, etc) play important roles in redox signal transduction and might be instrumental to uncover pathological mechanisms and identify novel therapeutic targets in neurodegenerative diseases. This Research Topic focuses on redox signaling mechanisms and aims to provide novel insights into the role of redox-signaling, with particular emphasis on redox regulation involving post-translational modifications, in the pathophysiology of neurodegenerative diseases. Moreover, it aims to present an overview of the potential of antioxidants as therapeutics for CNS disorders with a special focus on emerging novel therapeutic redox-based strategies. We are particularly interested in studies: -addressing new redox-based molecular mechanisms contributing to neurodegenerative diseases; -exploring the role of naturally occurring compounds, standard medications, and nutraceuticals with antioxidant properties in modulating redox-signaling pathways and limiting and/or preventing oxidative damage associated with these disorders; -addressing mechanistically the role of post-translational modifications in the pathophysiology of neurodegenerative disorders.
Disease Modifying Targets In Neurodegenerative Disorders
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Author : Veerle Baekelandt
language : en
Publisher: Academic Press
Release Date : 2017-03-31
Disease Modifying Targets In Neurodegenerative Disorders written by Veerle Baekelandt and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-31 with Medical categories.
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. - Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress - Summarizes how patients are treated today, providing a glance at future disease management - Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists - Written and peer reviewed by outstanding scientists in their respective fields