Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments
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Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments
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Author : Mariela Fernanda Perez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-20
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments written by Mariela Fernanda Perez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-20 with Science categories.
Mechanisms Of Neuroinflammation
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Author : Gonzalo Emiliano Aranda Abreu
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-08-23
Mechanisms Of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-23 with Medical categories.
"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Translational Medicine In Cns Drug Development
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Author : George G. Nomikos
language : en
Publisher: Academic Press
Release Date : 2019-06-18
Translational Medicine In Cns Drug Development written by George G. Nomikos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with Medical categories.
Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia
Inflammation And Epilepsy New Vistas
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Author : Damir Janigro
language : en
Publisher: Springer Nature
Release Date : 2021-05-18
Inflammation And Epilepsy New Vistas written by Damir Janigro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-18 with Medical categories.
This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
Cytokines And Pain
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Author : L.R. Watkins
language : en
Publisher: Springer
Release Date : 2013-03-08
Cytokines And Pain written by L.R. Watkins and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Etiology Of Parkinson S Disease
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Author : Jonas H. Ellenberg
language : en
Publisher: CRC Press
Release Date : 1995-03-01
Etiology Of Parkinson S Disease written by Jonas H. Ellenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Medical categories.
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
The Microbiology Of Central Nervous System Infections
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-02-17
The Microbiology Of Central Nervous System Infections written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-17 with Science categories.
The Microbiology of Central Nervous System Infections, Volume 3, discusses modern approaches to the diagnosis, treatment and prophylaxis of central nervous system (CNS) infections. This new release is divided into five sections that cover treatment strategies, imaging, molecular diagnosis, management of CNS infections with metal nanoparticles, and prophylaxis of CNS infections, including bacterial, viral and fungal infections. The last section contains a chapter on transmissible spongiform encephalopathies and modern trends in its diagnosis and treatment. University teachers, medical practitioners, graduate and postgraduate students, researchers in microbiology, and those in the pharmaceutical and laboratory diagnostic industries will find the book very important. Encompasses a broad range of central nervous system infections, including questions of etiology, pathogenesis, diagnosis, prognosis, treatment and prophylaxis Written by highly professional and eminent surgeons, microbiologists and infectious disease specialists Includes scientific understanding and practical guidelines, making it interesting for both research scientists and practitioners
Inflammation And Stroke
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Author : Giora Z. Feuerstein
language : en
Publisher: Springer Science & Business Media
Release Date : 2001
Inflammation And Stroke written by Giora Z. Feuerstein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
New opportunities for stroke prevention and therapeutics: a hope from anti-inflammatory drugs?.- Inflammation in stroke and CNS trauma - experimental and clinical evidence.- Clinical evidence of inflammation as a risk factor in ischemic stroke.- Inflammation as a risk factor for stroke: evidence from experimental models.- Inflammatory and immune responses to CNS injury: beneficial and detrimental components.- Salutary effect of autoimmune T cells after central nervous system injury.- Traumatic brain injury: is head trauma an inflammatory disease?.- Cyclic activation and inactivation of brain vessels involving inflammatory mediators - implications for stroke.- Inflammatory cells in stroke.- Do leukocytes play a role in focal ischemia in the brain? An objective review of the literature.- The role of microglia in ischemic brain injury.- Inflammatory activation of brain cells by hypoxia: transcription factors and signaling pathways.- Inflammatory cytokines, interleukins and chemokines in stroke and CNS trauma.- Cytokine effects on CNS cells: implications for the pathogenesis and prevention of stroke.- Interleukin-10 in cerebral ischemia and stroke.- Chemokines and ischemic stroke.- Biphasic activity of tumor necrosis factor in stroke and brain trauma: interaction with reactive oxygen species.- Interleukin-1 and IL-1 receptor antagonist in stroke: mechanisms and potential therapeutics.- Inflammatory cytokines in CNS trauma.- Inflammation in cerebral thrombosis, angiogenesis and matrix regulation: a new perspective in stroke research and therapeutics.- Microvessel integrin expression during focal cerebral ischemia.- The inflammatory response in focal cerebral ischemia.- Chronic neuronal perturbation mediated by RAGE, a receptor for ?-sheet fibrils and S100/calgranulins.- Mediators of inflammation and blood-brain barrier permeability in cerebral ischemia.- Inflammatory proteases and oxygen radicals in stroke.- The role of metalloproteinases on blood-brain barrier breakdown after ischemic stroke.- Matrix metalloproteinases and their inhibitors in hypoxia/reoxygenation and stroke.- Extracellular matrix-degrading metalloproteinases and neuroinflammation in stroke.- Anti-oxidant strategies to treat stroke.- Inflammatory adhesion molecules, kinins, nitric oxide complement factors and lipid mediators in stroke.- Selectin-and complement-mediated mechanisms of tissue injury in stroke.- The kallikrein-kinin system in ischemic and traumatic brain injury.- Nitric oxide, nitric oxide synthases and cyclooxygenase-2 in experimental focal stroke.
Systems Biology Of Free Radicals And Antioxidants
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Author : Ismail Laher
language : en
Publisher: Springer
Release Date : 2014-06-16
Systems Biology Of Free Radicals And Antioxidants written by Ismail Laher and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-16 with Medical categories.
The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Purinergic Signaling In Neurodevelopment Neuroinflammation And Neurodegeneration
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Author : Henning Ulrich
language : en
Publisher: Springer Nature
Release Date : 2023-07-16
Purinergic Signaling In Neurodevelopment Neuroinflammation And Neurodegeneration written by Henning Ulrich and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-16 with Medical categories.
This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.