Purinergic Signaling In Neurodevelopment Neuroinflammation And Neurodegeneration
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Purinergic Signaling In Neurodevelopment Neuroinflammation And Neurodegeneration
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Author : Henning Ulrich
language : en
Publisher: Springer Nature
Release Date : 2023-07-16
Purinergic Signaling In Neurodevelopment Neuroinflammation And Neurodegeneration written by Henning Ulrich and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-16 with Medical categories.
This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.
Purinergic Signalling In Neuron Glia Interactions
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-01
Purinergic Signalling In Neuron Glia Interactions written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-01 with Science categories.
ATP, the intracellular energy source, is also an extremely important cell–cell signalling molecule for a wide variety of cells across evolutionarily diverse organisms. The extracellular biochemistry of ATP and its derivatives is complex, and the multiple membrane receptors that it activates are linked to many intracellular signalling systems. Purinergic signalling affects a diverse range of cellular phenomena, including ion channel function, cytoskeletal dynamics, gene expression, secretion, cell proliferation, differentiation and cell death. Recently, this class of signalling molecules and receptors has been found to mediate communication between neurons and non-neuronal cells (glia) in the central and peripheral nervous systems. Glia are critical for normal brain function, development and response to injury. Neural impulse activity is detected by glia and purinergic signalling is emerging as a major means of integrating functional activity between neurons, glia and vascular cells in the nervous system. These interactions mediate effects of neural activity on the development of the nervous system and in association with injury, neurodegeneration, myelination and cancer. Bringing together contributions from experts in diverse fields, including glial biologists, neurobiologists and specialists in purinergic receptor structure and pharmacology, this book considers how extracellular ATP acts to integrate communication between different types of glia, and between neurons and glia. Beginning with an overview of glia and purinergic signalling, it contains detailed coverage of purine release, receptors and reagents, purinergic signalling in the neural control of glial development, glial involvement in information processing, and discussion of the interactions between neurons and microglia.
Brain Insulin Resistance In Neurodevelopmental And Neurodegenerative Disorders Mind The Gap
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Author : Eugenio Barone
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-04
Brain Insulin Resistance In Neurodevelopmental And Neurodegenerative Disorders Mind The Gap written by Eugenio Barone and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-04 with Science categories.
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
Transcription Regulation Brain Development And Homeostasis A Finely Tuned And Orchestrated Scenario In Physiology And Pathology Volume Ii
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Author : Estela Maris Muñoz
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-03
Transcription Regulation Brain Development And Homeostasis A Finely Tuned And Orchestrated Scenario In Physiology And Pathology Volume Ii written by Estela Maris Muñoz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-03 with Science categories.
A finely tuned regulation of gene expression is essential for shaping the nervous system and for maintaining its homeostasis throughout life. Disruptions in gene regulation can impact brain development and physiology in ways that contribute to diverse pathologies. The master orchestrators of gene activity in the nucleus are transcription factors, proteins that recognize and bind to specific DNA motifs in regulatory regions and drive changes in gene expression. Transcription factors act with the help of other co-factor proteins, including components of the Mediator complex, histone modifying enzymes, chromatin modelers, and DNA methylases. In addition, transcription factor activity in the nervous system can be modulated by extracellular signals, including growth factors, hormones, neuropeptides and neurotransmitters that activate specific receptors and intracellular transduction pathways. An in-depth understanding of the mechanisms of transcription regulation is needed in order to better describe how each element, from genes to cells, defines and maintains identities and functionalities in the healthy and diseased brain. This Research Topic is oriented to developing an integrative view about transcription regulation within the nervous system, focusing on developmental and homeostatic processes, dysregulation in functionality and expression levels and consequent associated pathologies such as neurodevelopmental disorders, brain tumors, and neurodegenerative diseases. Transcription regulation investigations will specifically focus on transcription factors that belong to the bHLH (e.g. NeuroD), homeobox (e.g. Islet, Pax, Rax, and Lhx) and CREB families, and on their roles over defined nervous system areas: cerebral cortex, thalamic and hypothalamic areas, interacting with the developing brain.
Gap Junctions Hemichannels And Pannexons New Implications In Neuroplasticity And Neuroinflammation
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Author : Juan Andrés Orellana
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-01
Gap Junctions Hemichannels And Pannexons New Implications In Neuroplasticity And Neuroinflammation written by Juan Andrés Orellana and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-01 with Science categories.
The Neuroscience Of Autism Spectrum Disorders
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Author : Joseph D. Buxbaum
language : en
Publisher: Academic Press
Release Date : 2012-12-31
The Neuroscience Of Autism Spectrum Disorders written by Joseph D. Buxbaum and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. - Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions - Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Cell Cell Interactions Controlling Cerebral Microvasculature Under Physiological And Pathophysiological Conditions
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Author : Xinchun Jin
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-29
Cell Cell Interactions Controlling Cerebral Microvasculature Under Physiological And Pathophysiological Conditions written by Xinchun Jin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-29 with Science categories.
Neuropharmacological Intervention For Severe Mental Illness And Suicide Prevention
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Author : Agnieszka Zelek-Molik
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-28
Neuropharmacological Intervention For Severe Mental Illness And Suicide Prevention written by Agnieszka Zelek-Molik and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-28 with Science categories.
Every 40s someone dies by suicide and for every person who completes a suicide, 20 or more may attempt to end their lives (WHO). Severe mental illness and substance use disorders or their comorbidity are among the most relevant risk factors for suicide. This Frontiers in Neuropharmacology Research Topic aims to improve education on the hot and sensitive topics of severe mental illness in comorbidity or not with substance use disorders and suicide ideation and raises awareness that these are preventable by addressing pharmacological interventions that could reduce the risk of suicide ideation among individuals suffering of a severe mental illness and/or substance use disorders. This article collection will welcome (but it’s not limited to) the following topics: • Suicide risk associated with substance use disorder and prevention • Suicide risk assessment and intervention in people with mental illness • Suicidality risk and medications/opioids treatments • Antidepressant medications and strategy for managing treatment-resistant depression • Molecular pathways associated with severe mental illness and suicidal ideation (ie: ketamine and mTOR signaling, Kynurenine Pathway, Therapy With Minocycline in Patients With Treatment-Resistant Depression, ketamine) • Sleep, antidepressants and anti-suicidal improvements • Pharmacological treatment that affects suicide (ie: Lithium and clozapine)
Cell Cell Interactions Controlling Neuronal Functionality In Health And Disease
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Author : Stefano Angiari
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-27
Cell Cell Interactions Controlling Neuronal Functionality In Health And Disease written by Stefano Angiari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
Microglia
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Author : Marie-Ève Tremblay
language : en
Publisher: Springer Nature
Release Date : 2024-08-29
Microglia written by Marie-Ève Tremblay and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-29 with Science categories.
The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases. Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these CNS diseases.