Brain Insulin Resistance In Neurodevelopmental And Neurodegenerative Disorders Mind The Gap
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Brain Insulin Resistance In Neurodevelopmental And Neurodegenerative Disorders Mind The Gap
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Author : Eugenio Barone
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-04
Brain Insulin Resistance In Neurodevelopmental And Neurodegenerative Disorders Mind The Gap written by Eugenio Barone and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-04 with Science categories.
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
Biochemistry Of Brain
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Author : Sudhir Kumar
language : en
Publisher: Pergamon
Release Date : 1980
Biochemistry Of Brain written by Sudhir Kumar and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.
Biochemistry of Brain is a collection of articles dealing with the developments in the biochemistry of the brain. This book gives a comprehensive and critical discussion of important developments in studies concerning the above subject. This text discusses the structure, function, and metabolism of glycosphingolipids, which are related to the study of sphingolipid storage diseases. Inborn defects of metabolism are found in Gaucher's and Fabry's disease, which are characterized by lipid accumulation in the brain. Another paper reviews the chemical and genetics of critically lysosomal hydrolase ...
Glucose Metabolism In The Brain
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Author :
language : en
Publisher: Elsevier
Release Date : 2002-11-04
Glucose Metabolism In The Brain written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-04 with Medical categories.
Regulation of glucose at the biochemical level affects every area of the brain, and has impact from cellular to behavioral brain function. It plays an important role in diseases such as diabetes, stroke, schizophrenia and drug abuse as well as in normal and dysfunctional memory and cognition. This volume represents a thorough examination of all the major issues that are relevant to glucose metabolism by brain cells in relation to disease, combining basic research and clinical findings in a single, indispensable reference. Serves as an essential reference on glucose metabolism in the brain Presents authoritative accounts by leading researchers in the field Includes thorough reviews with provocative sections on future directions
Pediatric Neuro Ophthalmology
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Author : Michael C. Brodsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-23
Pediatric Neuro Ophthalmology written by Michael C. Brodsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-23 with Medical categories.
"Due to the generous representation of the afferent visual system within the brain, neurological disease may disrupt vision as a presenting symptom or as a secondary effect of the disease. Conversely, early developmental disturbances of vision often disrupt ocular motor control systems, giving rise to complex disorders such as nystagmus, strabismus, and torticollis. The signs and symptoms of neurological disease are elusive by their very nature, presenting a confounding diagnostic challenge. Neurological medications and neurosurgical treatments can produce neuro-ophthalmological dysfunction that can be difficult to distinguish from disease progression. Affected patients may experience substantial delays in diagnosis, and are often subjected to extensive (and expensive) diagnostic testing. Scientific articles pertaining to specific disorders are scattered throughout medical subspecialty journals. These children continue to "fall through the cracks" of our medical education system. The increasing recognition that pediatric neuro-ophthalmology comprises a distinct set of diseases from those seen in adults has led to its emergence as a dedicated field of study. "Since the original publication of Pediatric Neuro-Ophthalmology nearly fourteen years ago, interest in the field has burgeoned. Pediatric ophthalmology and pediatric neurology subspecialty conferences often include symposia dedicated to recent advances in pediatric neuro-ophthalmology. Technical advances in neuroimaging have given rise to a more integrated mechanistic classification of neuro-ophthalmological disease in children. Our understanding of neurodevelopmental disorders of the visual system has expanded, longstanding monoliths have been dissembled into component parts, basic molecular mechanisms have taken center stage, and genetic underpinnings have become definitional. Evolutionary alterations can now be observed at the level of the gene, adding a new dimension to our understanding of disease pathogenesis. New classifications now encompass clinically disparate conditions. Descriptive definitions have been supplanted by mechanistic ones, and clinical definitions superseded by genetic ones. Our concept of disease pathogenesis has been revised and in some cases overturned. Bearing witness to these remarkable advancements has compelled me to enhance and expand the first edition of Pediatric Neuro-Ophthalmology into this new and revised one. "In the first edition of this book, our goal was to present the clinical characteristics, diagnostic evaluation, and therapeutic options for the common neuro-ophthalmologic disorders of childhood. In so doing, we designed the book to be provide a narrative journey through the thought processes involved in the clinical management of these disorders. In this edition, I have retained the basic narrative format of original book, while expanding the exploration of these complex visual disorders in the context of the many new scientific advancements and discoveries that have come to light. These conditions are fun to diagnose, fascinating to understand, and gratifying to manage." --from the Preface to the 2nd Edition.
Youth Mental Health
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Author : Peter J. Uhlhaas
language : en
Publisher: MIT Press
Release Date : 2020-04-14
Youth Mental Health written by Peter J. Uhlhaas and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-14 with Psychology categories.
Experts discuss the potential of early intervention to transform outcomes for people with mental disorders. Mental illness represents one of the largest disease burdens worldwide, yet treatments have been largely ineffective in improving the quality of life for millions of affected individuals—in part because approaches taken have focused on late-stage disorders in adulthood. This volume shifts the focus by placing the developmental stage of “youth” at the center of mental health. The contributors challenge current nosology, explore mechanisms that underlie the emergence of mental disorders, and propose a framework to guide early intervention. Offering recommendations for the future, the book holds that early intervention in youth has the potential to transform outcomes for people with mental disorders and to reconfigure the landscape of mental health. The contributors discuss epidemiology, classification, and diagnostic issues, including the benefits of clinical staging; the context for emerging mental disorders, including both biological and sociocultural processes; biological mechanisms underlying risk for psychopathology, including aspects of neural circuitry; and developing and implementing prevention and early intervention, including assessment and intervention modalities and knowledge translation in early treatment of schizophrenia. Contributors Nicholas B. Allen, Mario Alvarez-Jimenez, G. Paul Amminger, Shelli Avenevoli, Hannah F. Behrendt, Tolulope Bella-Awusah, Maximus Berger, Byron K. Y. Bitanihirwe, Drew Blasco, John D. Cahill, Joanne S. Carpenter, Andrew M. Chanen, Eric Y. H. Chen, Shane D. Colombo, Christoph U. Correll, Christopher G. Davey, Kim Q. Do, Damien A. Fair, Helen L. Fisher, Sophia Frangou, John Gleeson, Robert K. Heinssen, Ian B. Hickie, Frank Iorfino,Matcheri S. Keshavan, Kerstin Konrad, Phuong Thao D. Le, Francis Lee, Leslie D. Leve, Sarah A. Lieff, Cindy H. Liu, Beatriz Luna, Patrick D. McGorry, Urvakhsh Meherwan Mehta, Andreas Meyer-Lindenberg, Shreya V. Nallur, Cristopher Niell, Merete Nordentoft, Dost Öngür, George C. Patton, Tomáš Paus, Ulrich Reininghaus, Bernalyn Ruiz, Fred Sabb, Akira Sawa, Michael Schoenbaum, Gunter Schumann, Elizabeth M. Scott, Jai Shah, Vinod H. Srihari, Ezra Susser, John Torous, Peter J. Uhlhaas, Swapna K. Verma, T. Wilson Woo, Stephen J. Wood, Lawrence H. Yang, Alison R. Yung
Brain Repair After Stroke
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Author : Steven C. Cramer
language : en
Publisher: Cambridge University Press
Release Date : 2010-10-28
Brain Repair After Stroke written by Steven C. Cramer and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Medical categories.
Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.
The Pineal Gland
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Author : I. Nir
language : en
Publisher:
Release Date : 2015-01-07
The Pineal Gland written by I. Nir and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-07 with categories.
The Metabolic Inflammatory Axis In Brain Aging And Neurodegeneration
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Author : Fei Yin
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-16
The Metabolic Inflammatory Axis In Brain Aging And Neurodegeneration written by Fei Yin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with categories.
Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.