The Metabolic Inflammatory Axis In Brain Aging And Neurodegeneration
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The Metabolic Inflammatory Axis In Brain Aging And Neurodegeneration
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Author : Fei Yin
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-16
The Metabolic Inflammatory Axis In Brain Aging And Neurodegeneration written by Fei Yin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with categories.
Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.
Sex Hormones In Neurodegenerative Processes And Diseases
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Author : Gorazd Drevensek
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-05-02
Sex Hormones In Neurodegenerative Processes And Diseases written by Gorazd Drevensek and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-02 with Medical categories.
The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.
Sex Steroids Effects On Brain Heart And Vessels
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Author : Roberta Diaz Brinton
language : en
Publisher: Springer
Release Date : 2019-05-29
Sex Steroids Effects On Brain Heart And Vessels written by Roberta Diaz Brinton and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-29 with Medical categories.
This book analyzes the effects of estrogens and progesterone on brain cells, the immune system, neuro inflammation, myelin formation and steroid receptor distribution, as well as their clinical impacts. It also explores the relationship between sex-steroid withdrawal and the development of brain symptoms such as hot flushes, sleep disorders, mood changes, depression and also cognitive disorders and dementia, as well as the effects of hormone menopause therapy on such symptoms and diseases. Starting with obstetrical history and cardiovascular risk in later life, the second part of the book examines the effects of estrogens and progestogens on vascular tissues, atherosclerosis and coronary heart diseases, as well as the impact of hormone replacement therapies on cardiovascular risks and mortality. This volume is a useful, clear and up-to-date tool for gynecologists, endocrinologists, neurologists and cardiologists, and serves as a valuable source of information for all physicians involved in women’s health.
Neurodegenerative Diseases From Gut Brain Axis To Brain Microbiome
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Author : George Tetz
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-08
Neurodegenerative Diseases From Gut Brain Axis To Brain Microbiome written by George Tetz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-08 with Science categories.
While there are growing line of evidence for the role of the gut microbiome in different neurodegenerative diseases, the role and even the existence of the brain microbiome is only starting to be uncovered. Indeed, the brain was long considered to be a sterile environment and only recent studies have shown the presence of bacteria and fungi in the human central nervous system, and even inhabiting brain cells. The so called “brain microbiome” is appealing and immediately drew attention, since it is highly possible that microorganisms could have profound direct effects on a variety of processes in the brain, with the non-limiting examples of neurodegenerative and neurodevelopmental diseases triggering and progression. However, the brain microbiome remains poorly understood and even despite recent technological advances, is has only began to be explored.
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments
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Author : Mariela Fernanda Perez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-20
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments written by Mariela Fernanda Perez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-20 with Science categories.
Nutraceuticals For Aging And Anti Aging
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Author : Jayant Nemchand Lokhande
language : en
Publisher: CRC Press
Release Date : 2021-11-25
Nutraceuticals For Aging And Anti Aging written by Jayant Nemchand Lokhande and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-25 with Technology & Engineering categories.
Aging can be perceived differently during different times in one’s life. Aging as a process not only influences medical and economic dimensions at an individual level but also at societal and national levels. Aging is a natural process; however, its standard definition in a healthcare context is yet unclear. To delay the aging process and to maintain quality of life until the end of life are two goals of prime importance. Various healthcare approaches are being developed and experimented on to best manage aging as if it is a disease. Nutraceuticals are value-added dietary supplement products and have an immense potential in altering key structures and functions of aging. Nutraceuticals can be a keystone in altering sub-normal performing physiological and metabolic systems due to aging. Nutraceuticals for Aging and Anti-Aging: Basic Understanding and Clinical Evidence addresses aging and anti-aging nutraceuticals based on 10 major challenges, such as cognitive health, malnutrition, substance abuse, bladder control, and oral health, among others. It examines how these challenges can be complemented with nutraceuticals and connects the applications with the traditional wisdom of the aging process. Key Features Examines the aging process, then recommends nutraceuticals for aging and anti-aging processes Describes the aging process from the western perspective, and Ayurvedic medicine (Indian traditional system) and traditional Chinese medicine perspectives Provides, whenever possible, the clinical evidence of the applications of nutraceuticals for aging and anti-aging This book is a valuable resource for physicians, clinical experts, pharmaceutical companies and their experts, nutrition specialists, entrepreneurs, chemists, pharmacists, food chemists-technologists, as well as researchers and post-graduate students involved in these specialties. Also available in the Nutraceuticals: Basic Research/Clinical Applications Series: Bioactive Peptides: Production, Bioavailability, Health Potential, and Regulatory Issues, edited by John O. Onuh, M. Selvamuthukumaran, and Yashwant V. Pathak (ISBN: 978-0-3675-1177-7) Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, edited by Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, and Yashwant V. Pathak (ISBN 978-1-1383-4582-9) Advances in Nutraceutical Applications in Cancer: Recent Research Trends and Clinical Applications, edited by Sheeba Varghese Gupta, and Yashwant V. Pathak (ISBN 978-1-1385-9391-6)
Aging Peripheral Inflammation And Neurodegeneration
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Author : Caroline Haikal
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-26
Aging Peripheral Inflammation And Neurodegeneration written by Caroline Haikal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Science categories.
Aging is a major risk factor for several neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. The immune response is often dysregulated in aging, leading to a predisposition towards a state of chronic inflammation. The precise processes which support this inflammatory state are still a subject of debate, however, cell- and tissue-specific transcriptional changes in several immune-related genes have been identified as potential drivers. In addition to genetic changes, losses in the bacterial diversity within the microbiome are also observed during aging. However, it is unclear whether this may be a cause or consequence of inflammation. Host-microbiome interactions are highly complex and are known to modulate the immune response in several ways. For instance, while bacteria and some bacterial byproducts such as short chain fatty acids can induce differentiation of regulatory T cells and stimulate secretion of anti-inflammatory cytokines, other byproducts can activate pathogen recognition receptors to induce inflammation. Bacteria can also regulate the transcription of human genes that regulate immune homeostasis and pathogen response. In turn, microRNAs produced by the gut epithelium can regulate transcription in bacteria.
Brain Insulin Resistance In Neurodevelopmental And Neurodegenerative Disorders Mind The Gap
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Author : Eugenio Barone
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-04
Brain Insulin Resistance In Neurodevelopmental And Neurodegenerative Disorders Mind The Gap written by Eugenio Barone and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-04 with Science categories.
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
Neurodegenerative Diseases Looking Beyond The Boundaries Of The Brain
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Author : Elena Zenaro
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-25
Neurodegenerative Diseases Looking Beyond The Boundaries Of The Brain written by Elena Zenaro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-25 with Science categories.
Nutrition In The Control Of Inflammation
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Author : Bradley S. Ferguson
language : en
Publisher: Elsevier
Release Date : 2024-11-22
Nutrition In The Control Of Inflammation written by Bradley S. Ferguson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-22 with Technology & Engineering categories.
Nutrition in the Control of Inflammation: Emerging Roles for the Microbiome and Epigenome offers a comprehensive overview of how our diet promotes or attenuates inflammation to regulate inflammatory diseases.Broken into five sections, this book presents an introduction to the microbiome and epigenome in nutrition and subsequently covers diet, lifestyle, and the microbiome in development and inflammatory diseases, nutrition and the epigenome in metabolic and cardiovascular diseases, diet, epigenetics and the microbiome in inflammatory disease, and addresses health-disparities in diet, epigenetics and gut microbes.This reference will be of interest to nutrition researchers, nutritionists, and postgraduate students, as well as others working in, studying, and researching related fields. - Discusses the latest topics in the microbiome and nutritional epigenome surrounding the regulation of aging, development, metabolic disease, and heart disease - Summarizes our current understanding of nutritional intervention in epigenetic reprogramming and microbial changes in the treatment and prevention of disease - Provides practical applications for diet and lifestyle to reduce inflammation and improve overall health