Aging Peripheral Inflammation And Neurodegeneration

DOWNLOAD

Download Aging Peripheral Inflammation And Neurodegeneration PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Aging Peripheral Inflammation And Neurodegeneration book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Aging Peripheral Inflammation And Neurodegeneration

DOWNLOAD
Author : Caroline Haikal
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-26

Aging Peripheral Inflammation And Neurodegeneration written by Caroline Haikal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Science categories.

Aging is a major risk factor for several neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. The immune response is often dysregulated in aging, leading to a predisposition towards a state of chronic inflammation. The precise processes which support this inflammatory state are still a subject of debate, however, cell- and tissue-specific transcriptional changes in several immune-related genes have been identified as potential drivers. In addition to genetic changes, losses in the bacterial diversity within the microbiome are also observed during aging. However, it is unclear whether this may be a cause or consequence of inflammation. Host-microbiome interactions are highly complex and are known to modulate the immune response in several ways. For instance, while bacteria and some bacterial byproducts such as short chain fatty acids can induce differentiation of regulatory T cells and stimulate secretion of anti-inflammatory cytokines, other byproducts can activate pathogen recognition receptors to induce inflammation. Bacteria can also regulate the transcription of human genes that regulate immune homeostasis and pathogen response. In turn, microRNAs produced by the gut epithelium can regulate transcription in bacteria.

Clinical Immunology

DOWNLOAD
Author : Robert R. Rich
language : en
Publisher: Mosby Incorporated
Release Date : 2008

Clinical Immunology written by Robert R. Rich and has been published by Mosby Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.

Offers answers to challenges in clinical immunology. This book contains immunology knowledge and includes a companion web site to give you two ways to find the answers you need.

Decoding Aging And Neurodegeneration

DOWNLOAD
Author : Jan Barciszewski
language : en
Publisher: Springer Nature
Release Date : 2025-07-14

Decoding Aging And Neurodegeneration written by Jan Barciszewski and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-14 with Science categories.

This book focuses on the close relationship between aging and neurodegeneration. By highlighting the reversible nature of epigenetic changes, it provides a comprehensive overview of how these modifications can regulate gene expression without altering the DNA sequence, offering promising solutions for clinical intervention. Aging induces a gradual decline in cerebral function, leading to cognitive impairment, memory loss, motor dysfunction, and eventually functional decline and death. It is accompanied by the decline of organismal functions induced by whole genome alterations leading to neurodegeneration. Epigenetic modifications, including chromatin modifications, DNA methylation, and changes in regulatory RNAs, have a major impact on neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The chapters in this book address critical issues such as the contribution of epigenetic mechanisms to aging, the interaction between genetic and environmental factors in neurodegeneration, and the potential for epigenetic therapies to delay aging and mitigate disease progression. This volume, part of the RNA Technologies book series, is an invaluable resource for researchers and advanced students in genetics and neuroscience. It provides a deep understanding of the molecular basis of neurodegenerative diseases and offers innovative strategies to address the challenges of aging and neurodegeneration.

Nutrition And Immunity

DOWNLOAD
Author : Maryam Mahmoudi
language : en
Publisher: Springer
Release Date : 2019-07-30

Nutrition And Immunity written by Maryam Mahmoudi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-30 with Medical categories.

This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals.

The Perioperative Neurocognitive Disorders

DOWNLOAD
Author : Roderic G. Eckenhoff
language : en
Publisher: Cambridge University Press
Release Date : 2019-03-28

The Perioperative Neurocognitive Disorders written by Roderic G. Eckenhoff and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-28 with Medical categories.

A practical guide to perioperative cognitive disorders, the most common complications of anesthesia and surgery in older people.

The Metabolic Inflammatory Axis In Brain Aging And Neurodegeneration

DOWNLOAD
Author : Fei Yin
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-16

The Metabolic Inflammatory Axis In Brain Aging And Neurodegeneration written by Fei Yin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with categories.

Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.

Interphase Between Aging And Neurodegenerative Diseases

DOWNLOAD
Author : Walter E. Müller
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-21

Interphase Between Aging And Neurodegenerative Diseases written by Walter E. Müller and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-21 with categories.

The purpose of this Research Topic is to discuss the latest developments in aging and neurodegenerative diseases. Aging represents the major risk factor of the two most relevant neurodegenerative diseases Parkinson’s disease (PD) and Alzheimer’s disease (AD). It is generally accepted that symptoms of PD correlate with the severity of degeneration of dopaminergic substantia nigra neurons. In most cases neuronal loss during aging is not sufficient to cause clinical symptoms but only leads to a preclinical state of PD. However, in a small number of our population, neurodegeneration by aging gets accelerated by individual (e.g. brain injuries), environmental (e.g. toxins) and genetic (e.g. mutations of the alpha-synuclein gene) factors to reach the critical threshold for clinical symptoms during lifetime. Thus, neurodegeneration in PD appears to represent the common final pathway of “normal brain aging” and all other risk factors including genetics and the accumulation of the neurotoxic alpha-synuclein protein. While aging alone is generally agreed to be sufficient for at least the preclinical state of PD, the situation in AD seems to be different. Aging as the major and well documented risk factor of AD has been neglected for decades. Biochemical mechanisms of brain aging and the cognitive deficits of “normal brain aging” were seen as two not related and independent processes not related to AD. AD has always been characterized for decades by the presence of histopathological alterations (extracellular amyloid- containing plaques and intracellular tangles of hyperphosphorylated tau-protein), by neurodegeneration (synaptic deficits and finally neuronal loss), as well as by severe cognitive deficits clinically often accompanied by neuropsychiatric symptoms like delusions, as already described in the first famous patient Auguste D at the Psychiatric Hospital of Frankfurt. If or if not one or both of the two histopathological hallmarks play a causative role remains unclear until now. The discovery of homocygotic risk genes in most of the very rare (probably less than 1%) cases of early onset AD which share increased production of β-amyloid (Aβ) as one (but probably not the only one) common property led to the hypothesis of Aβ as the major causative factor for the development of AD. It was neglected that plaques density in the brain of AD patients did not correlate with presence and severity of clinical symptoms, while synaptic deficits did so even in first observations already published many years ago. Based on the Amyloid hypothesis, many drug treatments to remove Aβ plaques were developed. Even if all seemed to remove Aβ to some extent, all strategies failed to improve the symptoms of dementia. Thus, other concepts to explain the development of clinical symptoms of AD over time are needed. These should include the brain aging process not only as a statistical but also as a causative contributing factor. These concepts should not only relay on cell or animal models but should much more take into account the disease and the patients. A closer look at the situation in PD will certainly be helpful.

Epigenetics Of Aging

DOWNLOAD
Author : Trygve O. Tollefsbol
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-11

Epigenetics Of Aging written by Trygve O. Tollefsbol and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-11 with Medical categories.

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

The Molecular And Cellular Basis Of Neurodegenerative Diseases

DOWNLOAD
Author : Michael S. Wolfe
language : en
Publisher: Academic Press
Release Date : 2018-03-29

The Molecular And Cellular Basis Of Neurodegenerative Diseases written by Michael S. Wolfe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-29 with Medical categories.

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts

The Neurobiology Of Aging And Alzheimer Disease In Down Syndrome

DOWNLOAD
Author : Elizabeth Head
language : en
Publisher: Academic Press
Release Date : 2021-08-31

The Neurobiology Of Aging And Alzheimer Disease In Down Syndrome written by Elizabeth Head and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-31 with Medical categories.

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research