Mechanisms Of Neuroinflammation
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Mechanisms Of Neuroinflammation
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Author : Gonzalo Emiliano Aranda Abreu
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-08-23
Mechanisms Of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-23 with Medical categories.
"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Mechanisms Of Neuroinflammation
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Author :
language : en
Publisher:
Release Date : 19??
Mechanisms Of Neuroinflammation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.
Mechanisms Of Neuroinflammation And Inflammatory Neurodegeneration In Acute Brain Injury
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Author : Arthur Liesz
language : en
Publisher: Frontiers Media SA
Release Date : 2015-11-13
Mechanisms Of Neuroinflammation And Inflammatory Neurodegeneration In Acute Brain Injury written by Arthur Liesz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-13 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.
Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives
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Author : Morena Zusso
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-14
Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives written by Morena Zusso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-14 with categories.
Neuroinflammation Mechanisms And Management
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Author : Alfred Galswells
language : en
Publisher: American Medical Publishers
Release Date : 2021-11-16
Neuroinflammation Mechanisms And Management written by Alfred Galswells and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-16 with Medical categories.
Inflammation is the biological response towards pathogens and damaged cells exhibited by the body tissues. The inflammation of the nervous tissues is known as neuroinflammation. It may occur in response to a number of causes such as infection, toxic metabolites or traumatic brain injury. Brain and spinal cord, that make the central nervous system, have immune cells known as microglia. These cells are activated during neuroinflammation. It usually refers to the chronic inflammation of the central nervous system, instead of acute inflammation. During chronic inflammation, there is a sustained activation of glial cells and recruitment of other immune cells into the brain. Some other causes of chronic neuroinflammation are ageing, air pollution, passive smoking, spinal cord injury and microbes. This book traces the progress in the field of neuroscience in relation to the management and mechanisms in neuroinflammation. Also included herein is a detailed explanation of the various aspects of this disease. This book aims to equip students and experts with the advanced topics in this disease.
Biomarkers Of Neuroinflammation
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2018-03-16
Biomarkers Of Neuroinflammation written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-16 with Medical categories.
Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments
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Author : Mariela Fernanda Perez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-20
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments written by Mariela Fernanda Perez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-20 with Science categories.
Molecular Mechanisms Of Neuroinflammation
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Author :
language : en
Publisher:
Release Date : 2006
Molecular Mechanisms Of Neuroinflammation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Molecular Mechanisms Of Neuroinflammation Following Global Cerebral Ischemia The Role Of Hypothermia Therapy
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Author : Anh Thi Ngoc Nguyen
language : en
Publisher:
Release Date : 2011
Molecular Mechanisms Of Neuroinflammation Following Global Cerebral Ischemia The Role Of Hypothermia Therapy written by Anh Thi Ngoc Nguyen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Hypothermia therapy (HT) is used clinically following global cerebral ischemia (GCI) but its therapeutic mechanisms are not completely understood. An elucidation of such mechanisms may lead to novel therapeutic approaches that improve patient outcome. Using a murine model of GCI, we determined the effect of HT on the expression of inflammatory proteins in the hippocampus and serum. We also examined its effect on microglia/macrophage activation and neurodegeneration in the brain at 72 hours following ischemia, and its effect on long-term spatial memory/learning and contextual fear response. GCI led to increased neurodegeneration and microglia/macrophage activation in the hippocampus, and increased IL-1beta and KC protein expression in the hippocampus at 72 hours. Hypothermia therapy attenuated these inflammatory responses. It also improved spatial learning/memory at 7 and 21 days, and preserved contextual fear response 21 days post-ischemia. Hypothermia therapy attenuated the post-ischemic inflammatory response, protected hippocampal neurons, and preserved long-term memory and learning.
Neuroinflammation And Neurodegeneration
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Author : Phillip K. Peterson
language : en
Publisher: Springer
Release Date : 2014-07-08
Neuroinflammation And Neurodegeneration written by Phillip K. Peterson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.
