New Non Opioid Analgesics Understanding Molecular Mechanisms On The Basis Of Patch Clamp And Chemical Studies
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New Non Opioid Analgesics Understanding Molecular Mechanisms On The Basis Of Patch Clamp And Chemical Studies
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Author : Boris V. Krylov
language : en
Publisher: Bentham Science Publishers
Release Date : 2017-06-12
New Non Opioid Analgesics Understanding Molecular Mechanisms On The Basis Of Patch Clamp And Chemical Studies written by Boris V. Krylov and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-12 with Science categories.
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief. Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids. This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Understanding Molecular Mechanisms On The Basis Of Patch Clamp And Quantum Chemical Studies New Non Opioid Analgesics
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Author : Ilia V. Rogachevskii
language : en
Publisher: Frontiers in Pain Science
Release Date : 2017-06-12
Understanding Molecular Mechanisms On The Basis Of Patch Clamp And Quantum Chemical Studies New Non Opioid Analgesics written by Ilia V. Rogachevskii and has been published by Frontiers in Pain Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-12 with Medical categories.
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor ? Na+,K+-ATPase ? NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief.Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids.This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1988
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medicine categories.
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1995
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medicine categories.
Biomedical Index To Phs Supported Research Pt A Subject Access A H
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Author :
language : en
Publisher:
Release Date : 1992
Biomedical Index To Phs Supported Research Pt A Subject Access A H written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medicine categories.
Novel Psychoactive Substances
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Author : Paul I. Dargan
language : en
Publisher: Academic Press
Release Date : 2021-09-06
Novel Psychoactive Substances written by Paul I. Dargan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-06 with Medical categories.
Novel Psychoactive Substances: Classification, Pharmacology and Toxicology, Second Edition provides readers with a comprehensive examination on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." The book covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance and a discussion of their associated acute and chronic harm and toxicity. This second edition addresses drugs new to the scene, with completely updated and revised chapters. Written by international experts in the field, this multi-authored book is an essential reference for scientists, clinicians, academics, and regulatory and law enforcement professionals. Includes chapters written by international experts in the field Presents a comprehensive overview on the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene, including amphetamines and the synthetic cannabinoid receptors in ‘spice’ and ‘K2’
Drug Discovery And Evaluation
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Author : Hans G. Vogel
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Drug Discovery And Evaluation written by Hans G. Vogel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.
Acute Pain Management
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Author : Raymond S. Sinatra
language : en
Publisher: Cambridge University Press
Release Date : 2009-04-27
Acute Pain Management written by Raymond S. Sinatra and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-27 with Medical categories.
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Caffeine In Food And Dietary Supplements
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Author : Leslie A. Pray
language : en
Publisher:
Release Date : 2014
Caffeine In Food And Dietary Supplements written by Leslie A. Pray and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Health & Fitness categories.
Caffeine in Food and Dietary Supplements is the summary of a workshop convened by the Institute of Medicine in August 2013 to review the available science on safe levels of caffeine consumption in foods, beverages, and dietary supplements and to identify data gaps. Scientists with expertise in food safety, nutrition, pharmacology, psychology, toxicology, and related disciplines; medical professionals with pediatric and adult patient experience in cardiology, neurology, and psychiatry; public health professionals; food industry representatives; regulatory experts; and consumer advocates discussed the safety of caffeine in food and dietary supplements, including, but not limited to, caffeinated beverage products, and identified data gaps. Caffeine, a central nervous stimulant, is arguably the most frequently ingested pharmacologically active substance in the world. Occurring naturally in more than 60 plants, including coffee beans, tea leaves, cola nuts and cocoa pods, caffeine has been part of innumerable cultures for centuries. But the caffeine-in-food landscape is changing. There are an array of new caffeine-containing energy products, from waffles to sunflower seeds, jelly beans to syrup, even bottled water, entering the marketplace. Years of scientific research have shown that moderate consumption by healthy adults of products containing naturally-occurring caffeine is not associated with adverse health effects. The changing caffeine landscape raises concerns about safety and whether any of these new products might be targeting populations not normally associated with caffeine consumption, namely children and adolescents, and whether caffeine poses a greater health risk to those populations than it does for healthy adults. This report delineates vulnerable populations who may be at risk from caffeine exposure; describes caffeine exposure and risk of cardiovascular and other health effects on vulnerable populations, including additive effects with other ingredients and effects related to pre-existing conditions; explores safe caffeine exposure levels for general and vulnerable populations; and identifies data gaps on caffeine stimulant effects.
Cell Tissue Injury And Cytoprotection Organoprotection In The Gastrointestinal Tract
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Author : Ludmila P. Filaretova
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2012
Cell Tissue Injury And Cytoprotection Organoprotection In The Gastrointestinal Tract written by Ludmila P. Filaretova and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.