Nicotinic Acetylcholine Receptors In The Nervous System
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Nicotinic Acetylcholine Receptors In The Nervous System
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Author : Francesco Clementi
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Nicotinic Acetylcholine Receptors In The Nervous System written by Francesco Clementi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The acetylcholine nicotinic receptor is an ionic channel whose aperture is directly controlled by acetylcholine. It is a key molecule in the chemical communication between nerve cells and between nerve cell and muscle. The structure and function of muscular nicotinic receptors have been unraveled in recent years and its beauty and mysteries were reviewed in the Santorini NATO ARW organized by Dr. Maelicke in 1986. The neat, linear structure of this molecule and its conservation throughout evolution, from bacteria to humans, have led to the suggestion that it has reached the optimal structure for performing its function. But when scientists began to look at the nicotinic receptor in the nervous system, they found several surprises. From the beginning, pharmacological and physiological experiments, have made it clear that the functional characteristics of neuronal nicotinic receptors are substantially different from those of muscle receptors. Furthermore, recent sophisticated techniques such as patch clamp and gene cloning have revealed that the nicotinic receptor in the nervous system is not a single molecule but (although there are some important exceptions) a large family of similar molecules, which have in common the property of binding nicotinic agonists or antagonists. Over the last few years, the physiological implications of nicotinic receptors have been reevaluated on the basis of more precise behavioural and pharmacological techniques. Moreover, the involvement of nicotinic receptors in degenerative pathologies of the eNS, such as Parkinson's and Alzheimer's disease, has also been discovered very recently.
Nicotinic Receptors In The Nervous System
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Author : Edward D. Levin
language : en
Publisher: CRC Press
Release Date : 2001-08-29
Nicotinic Receptors In The Nervous System written by Edward D. Levin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-08-29 with Medical categories.
Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of research on neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, the book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments. The book presents readers with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects.
Nicotinic Acetylcholine Receptors In Health And Disease
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Author : R. Thomas Boyd
language : en
Publisher: Academic Press
Release Date : 2023-03-14
Nicotinic Acetylcholine Receptors In Health And Disease written by R. Thomas Boyd and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.
Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders. Describes the roles, expression and function of nicotinic receptors Includes receptor involvement, both inside and outside the nervous system Details nicotinic receptor involvement in Alzheimer’s, Parkinson’s, Cancer, Schizophrenia, and more Emphasizes future treatment prospects of disorders via modulation of nAChR signaling
Neuronal Acetylcholine Receptors
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Author : V.I. Skok
language : en
Publisher: Springer
Release Date : 2012-03-22
Neuronal Acetylcholine Receptors written by V.I. Skok and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-22 with Science categories.
Among the different types of receptors for neurotransmitters, nicotinic acetyl choline receptors were the first to be studied systematically; at present they are very well characterized. This is due to the discovery of two very convenient objects that are endowed with nicotinic acetylcholine receptors - the skeletal muscle and the electric organ. The large size of skeletal muscle fibers, which simplifies the intra cellular recording of transmembrane potentials and currents, played a crucial role in obtaining the fIrst quantitative estimates of the activity of acetylcholine receptors and the kinetics of their interaction with ligands. On the other hand, the extremely high content of receptor protein in the electric organ tissue - two orders higher than in muscle tissue - rendered it highly suitable for studying the biochemistry of recep tors. The combination of pharmacological, electrophysiological, and biochemical approaches resulted in rapid progress in the investigation of acetylcholine receptors. Nicotinic acetylcholine receptors are also present in the neurons of autonomic ganglia, in the central nervous system of vertebrates, and in the ganglion neurons of invertebrates. Although each of these three types of receptors has its own pharma cological specificity, some of their properties are common and differ from those in the acetylcholine receptors of skeletal muscle and electric organ. One of these differences is that neuronal nicotinic receptors usually coexist in the same nerve cell with other receptors, e. g. , muscarinic, serotoninergic, or peptidergic.
Neuronal Nicotinic Acetylcholine Receptors In The Rat Autonomic Nervous System
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Author : Gabriele Rust
language : en
Publisher:
Release Date : 1995
Neuronal Nicotinic Acetylcholine Receptors In The Rat Autonomic Nervous System written by Gabriele Rust and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Neuronal Acetylcholine Receptors
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Author : V.I. Skok
language : en
Publisher: Springer
Release Date : 2013-05-14
Neuronal Acetylcholine Receptors written by V.I. Skok and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-14 with Science categories.
Among the different types of receptors for neurotransmitters, nicotinic acetyl choline receptors were the first to be studied systematically; at present they are very well characterized. This is due to the discovery of two very convenient objects that are endowed with nicotinic acetylcholine receptors - the skeletal muscle and the electric organ. The large size of skeletal muscle fibers, which simplifies the intra cellular recording of transmembrane potentials and currents, played a crucial role in obtaining the fIrst quantitative estimates of the activity of acetylcholine receptors and the kinetics of their interaction with ligands. On the other hand, the extremely high content of receptor protein in the electric organ tissue - two orders higher than in muscle tissue - rendered it highly suitable for studying the biochemistry of recep tors. The combination of pharmacological, electrophysiological, and biochemical approaches resulted in rapid progress in the investigation of acetylcholine receptors. Nicotinic acetylcholine receptors are also present in the neurons of autonomic ganglia, in the central nervous system of vertebrates, and in the ganglion neurons of invertebrates. Although each of these three types of receptors has its own pharma cological specificity, some of their properties are common and differ from those in the acetylcholine receptors of skeletal muscle and electric organ. One of these differences is that neuronal nicotinic receptors usually coexist in the same nerve cell with other receptors, e. g. , muscarinic, serotoninergic, or peptidergic.
Nicotinic Receptors
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Author : Robin A.J. Lester
language : en
Publisher: Springer
Release Date : 2014-11-11
Nicotinic Receptors written by Robin A.J. Lester and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-11 with Medical categories.
A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.
Neuronal Nicotinic Receptors
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Author : F. Clementi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neuronal Nicotinic Receptors written by F. Clementi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.
Neuronal Nicotinic Acetylcholine Receptors In The Rat Automatic Nervous System
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Author : Gabriele Rust
language : en
Publisher:
Release Date : 1995
Neuronal Nicotinic Acetylcholine Receptors In The Rat Automatic Nervous System written by Gabriele Rust and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection
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Author : Akinori Akaike
language : en
Publisher: Springer
Release Date : 2018-04-04
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection written by Akinori Akaike and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-04 with Medical categories.
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.