Nitric Oxide Signaling In The Nervous System
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Nitric Oxide Signaling In The Nervous System
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Author : Jay E. Brenman
language : en
Publisher:
Release Date : 1996
Nitric Oxide Signaling In The Nervous System written by Jay E. Brenman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Nitric Oxide In The Nervous System
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-04-07
Nitric Oxide In The Nervous System written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-07 with Medical categories.
The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested.This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO. Key Features* Describes how and why NO is produced in the nervous system* Examines all that is known of NOs role as a neurotransmitter* Explores cellular actions and physiological roles in the brain and peripheral nervous systemCovers NOs molecular synthesis to its role in neuropathology
Functional Neuroanatomy Of The Nitric Oxide System
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Author : H.W.M. Steinbusch
language : en
Publisher: Elsevier
Release Date : 2000-06-30
Functional Neuroanatomy Of The Nitric Oxide System written by H.W.M. Steinbusch and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-06-30 with Psychology categories.
This volume of the Handbook of Neuroanatomy is concerned with nitric oxide synthase. In this volume different research areas are presented together, which adds up to the first major review volume on the localization of nitric oxide synthase in the nervous system. The subjects range from developmental aspects in vertebrates to a functional neuroanatomy of the nervous system in vertebrates. This presentation gives an impressive look on the overwhelming presence of NOS in animal organism and the significance of NO - cGMP signaling. By clearly stating the limitations of our present knowledge the book is also a stimulant for further research. This book presents for the first time an overview of NOS and NO-cGMP signaling in the retina and urogenital system. In addition the effects if injuries on the expression of NOS are summarized in a number of models, which has not been done before.The frame of the book is a classical neuroanatomic description of the localization of NOS. Several authors give detailed advice to prevent pitfalls which may occur when different methods to locate NOS are used. In addition, several chapters detail the target structures for NO while describing the localization of NOS at the same time.All these points together make this volume very timely, i.e. overviewing a decade of NO research.
Nitric Oxide Mediated Cgmp Signal Transduction In The Central Nervous System
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Author : Katalin Bartus
language : en
Publisher:
Release Date : 2010
Nitric Oxide Mediated Cgmp Signal Transduction In The Central Nervous System written by Katalin Bartus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Nitric Oxide
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Author :
language : en
Publisher: Elsevier
Release Date : 2011-09-02
Nitric Oxide written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-02 with Science categories.
This volume provides a novel insight to the evolutionary and comparative aspects of nitric oxide- nitric oxide synthase system as a central regulator of invertebrate and vertebrate homeostasis. By critically selecting and summarizing the ever–increasing number of original studies, these presentations review a variety of important signalling and modulatory roles played by nitric oxide at molecular, cell, organ and organ system levels. It addresses not only specialists and graduate students in the field, but also all biologists concerned with how this unique, gaseous, pleiotropic molecule has been employed by living systems, uncovering a new dimension of the wonders of life.
Functional Neuroanatomy Of The Nitric Oxide System
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Author : Hendrik Wilhelm Maria Steinbusch
language : en
Publisher: Elsevier Science
Release Date : 2000
Functional Neuroanatomy Of The Nitric Oxide System written by Hendrik Wilhelm Maria Steinbusch and has been published by Elsevier Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
This volume of the Handbook of Neuroanatomy is concerned with nitric oxide synthase. In this volume different research areas are presented together, which adds up to the first major review volume on the localization of nitric oxide synthase in the nervous system. The subjects range from developmental aspects in vertebrates to a functional neuroanatomy of the nervous system in vertebrates. This presentation gives an impressive look on the overwhelming presence of NOS in animal organism and the significance of NO - cGMP signaling. By clearly stating the limitations of our present knowledge the book is also a stimulant for further research. This book presents for the first time an overview of NOS and NO-cGMP signaling in the retina and urogenital system. In addition the effects if injuries on the expression of NOS are summarized in a number of models, which has not been done before. The frame of the book is a classical neuroanatomic description of the localization of NOS. Several authors give detailed advice to prevent pitfalls which may occur when different methods to locate NOS are used. In addition, several chapters detail the target structures for NO while describing the localization of NOS at the same time. All these points together make this volume very timely, i.e. overviewing a decade of NO research.
Functional Neuroanatomy Of The Nitric Oxide System
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Author : Hendrik Wilhelm Maria Steinbusch
language : en
Publisher: Elsevier Science & Technology
Release Date : 2014-05-14
Functional Neuroanatomy Of The Nitric Oxide System written by Hendrik Wilhelm Maria Steinbusch and has been published by Elsevier Science & Technology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-14 with Medical categories.
This volume of the "Handbook of Neuroanatomy" is concerned with nitric oxide synthase. In this volume different research areas are presented together, which adds up to the first major review volume on the localization of nitric oxide synthase in the nervous system. The subjects range from developmental aspects in vertebrates to a functional neuroanatomy of the nervous system in vertebrates. This presentation gives an impressive look on the overwhelming presence of NOS in animal organism and the significance of NO - cGMP signaling. By clearly stating the limitations of our present knowledge the book is also a stimulant for further research. This book presents for the first time an overview of NOS and NO-cGMP signaling in the retina and urogenital system. In addition the effects if injuries on the expression of NOS are summarized in a number of models, which has not been done before. The frame of the book is a classical neuroanatomic description of the localization of NOS. Several authors give detailed advice to prevent pitfalls which may occur when different methods to locate NOS are used. In addition, several chapters detail the target structures for NO while describing the localization of NOS at the same time. All these points together make this volume very timely, i.e. overviewing a decade of NO research.
Nitric Oxide
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Author : Louis J. Ignarro
language : en
Publisher: Academic Press
Release Date : 2000-09-13
Nitric Oxide written by Louis J. Ignarro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-13 with Medical categories.
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense
Nitric Oxide Mediated Cgmp Signal Transduction In The Central Nervous System
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Author : K. Bartus
language : en
Publisher:
Release Date : 2010
Nitric Oxide Mediated Cgmp Signal Transduction In The Central Nervous System written by K. Bartus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Nitric oxide (NO) functions as a signalling molecule throughout the brain where, via the intracellular generation of cGMP, it participates in many functions, such as in synaptic plasticity. The initial experiments were based on the finding that, in optic nerve, NO released from blood vessels tonically depolarises axons. The aim was to test the hypothesis that the tonic NO production is maintained by phosphorylation of endothelial NO synthase (eNOS). The results from extracellular recordings of changes in the axonal membrane potential suggested that PI3 kinase-mediated eNOS phosphorylation is partially responsible. The subsequent aim was to determine if blood vessel-neuron communication may be more widespread, by investigating if this mechanism accounts for basal NO production in the developing rat hippocampus. For this purpose, measurements of cGMP were chosen as a sensitive index of the local NO concentration. Contrary to expectations, no clear evidence for a dominant role of either eNOS or the neuronal NO synthase emerged, although the data suggested that NO formation was calcium-dependent. The next step was to characterise the target cells of endogenous and exogenous NO in the hippocampus, particularly in the light of findings that, with a better tool for inhibiting the dominant phosphodiesterase activity (phosphodiesterase-2), much higher cGMP levels could be evoked than previously. Accordingly, instead of a predominant location in astrocytes, cGMP immunocytochemistry showed widespread staining of neuronal elements (somata, dendrites, neuropil) throughout the tissue. The final objective was to begin to analyse NO transduction in cells in real-time, using a newly developed fluorescent cGMP sensor. Cell lines expressing various levels of guanylyl cyclase and phosphodiesterase were selected for study. Cellular responsiveness to extremely low NO concentrations (down to 3 pM) could be detected. Moreover, the findings illustrated how the interplay between guanylyl cyclase and phosphodiesterase activities serves to generate distinct cellular cGMP profiles.
Nitric Oxide Signalling In The Nervous System Of The Locust Schistocerca Gregaria
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Author : Richard Adrian Colbert
language : en
Publisher:
Release Date : 1997
Nitric Oxide Signalling In The Nervous System Of The Locust Schistocerca Gregaria written by Richard Adrian Colbert and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.