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Nk Cell Based Cancer Immunotherapy

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Nk Cell Based Cancer Immunotherapy

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Author : Francisco Borrego
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-08

Nk Cell Based Cancer Immunotherapy written by Francisco Borrego and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-08 with Immunologic diseases. Allergy categories.

Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

Nk Cell Based Cancer Immunotherapy

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Author :
language : en
Publisher:
Release Date : 2016

Nk Cell Based Cancer Immunotherapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Molecular Strategies Aimed To Boost Nk Cell Based Immunotherapy Of Cancer

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Author : Loredana Cifaldi
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-31

Molecular Strategies Aimed To Boost Nk Cell Based Immunotherapy Of Cancer written by Loredana Cifaldi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with categories.

In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.

Nk Cells In Cancer Immunotherapy Successes And Challenges

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Author : Anahid Jewett
language : en
Publisher: Academic Press
Release Date : 2022-12-06

Nk Cells In Cancer Immunotherapy Successes And Challenges written by Anahid Jewett and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-06 with Science categories.

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies

Innate Immune Cell Therapy Of Cancer

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Author : Asha B. Pillai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-13

Innate Immune Cell Therapy Of Cancer written by Asha B. Pillai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Science categories.

Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.

Gene And Cellular Immunotherapy For Cancer

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Author : Armin Ghobadi
language : en
Publisher: Springer Nature
Release Date : 2022-01-01

Gene And Cellular Immunotherapy For Cancer written by Armin Ghobadi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Medical categories.

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Successes And Challenges Of Nk Immunotherapy

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Author : Benjamin Bonavida
language : en
Publisher: Academic Press
Release Date : 2021-06-23

Successes And Challenges Of Nk Immunotherapy written by Benjamin Bonavida and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-23 with Science categories.

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

Critical Issues In Head And Neck Oncology

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Author : Jan B. Vermorken
language : en
Publisher: Springer Nature
Release Date : 2023-03-27

Critical Issues In Head And Neck Oncology written by Jan B. Vermorken and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-27 with Medical categories.

This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Cancer Immunotherapy

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Author : Sarah S. Donatelli
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-06-04

Cancer Immunotherapy written by Sarah S. Donatelli and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-04 with Medical categories.

Natural Killer (NK) cells are a unique subset of lymphocytes genetically programmed to locate and destroy cellular malignancies. They accomplish this through unique cell surface receptors that, upon contacting a target cell, transmit either inhibitory or activating intracellular signals, ultimately determining whether the target cell will be killed or spared. Acquisition of the capacity to kill comes only after the NK cell is rendered tolerant to healthy self cells through interaction with naturally expressed MHC I molecules. The resulting functional NK cell is endowed with both repressive and stimulatory receptors that recognize MHC I or MHC I-related proteins, and stress-induced proteins that are not normally expressed by healthy cells, respectively. The respective signaling pathways are generally conserved among receptors; consequently, mechanisms that dysregulate NK-cell surface receptor density may directly impair NK responsiveness towards cancerous cells by affecting the ratio of inhibitory-to-activating signals. Furthermore, activating receptors can be downregulated, suggesting a targeted evasion strategy that specifically converts the NK cell towards an inhibitory phenotype.

New Insights Into Innate Immune Cell Based Immunotherapies In Cancer

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Author : Mary Poupot-Marsan
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-17

New Insights Into Innate Immune Cell Based Immunotherapies In Cancer written by Mary Poupot-Marsan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-17 with Medical categories.

Nk Cell Based Cancer Immunotherapy

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