Nk Myeloid Cell Interactions In The Tumor Microenvironment Implications For Cancer Immunotherapy
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Nk Myeloid Cell Interactions In The Tumor Microenvironment Implications For Cancer Immunotherapy
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Author : Erik Wennerberg
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-08
Nk Myeloid Cell Interactions In The Tumor Microenvironment Implications For Cancer Immunotherapy written by Erik Wennerberg and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-08 with Medical categories.
Cancer Immunotherapy
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-10-24
Cancer Immunotherapy written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-24 with Science categories.
Cancer Immunotherapy, Volume 209 covers the progress that has been made in cancer immunotherapy. This volume surveys exciting developments in the field while also highlighting its promise and problems. Chapters in this release include The Promise, Progress, and Challenges of In Situ Immunization Agents in Cancer Immunotherapy, Breakthroughs in Synthetic Controlling Strategies for Precision in CAR-T Therapy, Non-coding RNAs in cancer immunotherapy: a solution to overcome immune resistance?, Rational Design of adjuvants boosts cancer vaccines, Emerging Drug delivery systems to alter Tumor immunosuppressive microenvironment: overcoming the challenges in immunotherapy for Glioblastoma.Other chapters cover Magnetic Nanoparticles: An Emerging Nanomedicine for Cancer Immunotherapy and Clinical and basic science aspects of innate lymphoid cells as novel immunotherapeutic targets in cancer treatment. - Discusses immune surveillance of tumors and how it is compromised - Presents new approaches to the development and delivery of cancer vaccines and cytotoxic T-cells to the tumor site - Demonstrates how new molecular biological approaches may augment the efficacy of CAR-T cells and dampen the effects of non-coding RNAs
Advances In Cancer Immunotherapy
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Author : Shin Mukai
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-09-18
Advances In Cancer Immunotherapy written by Shin Mukai and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-18 with Medical categories.
Cancer immunotherapy utilizes the immune system to identify and target cancer cells. Over the past decades, researchers have advanced these treatments by (1) uncovering how tumors evade the immune system and (2) developing techniques to trigger an anti-tumor immune response and block tumor immune escape. These immunotherapies can be administered alone or in combination with other treatments, leading to an improved survival rate and quality of life for cancer patients. Indeed, several immunotherapies have received approval from the United States Food and Drug Administration (FDA) for the treatment of various cancers. For instance, blocking PD-1/PD-L1 has increased the five-year survival rate for patients with advanced non-small-cell lung cancer. However, the effectiveness of current immunotherapies varies significantly among patients, and they can cause severe side effects. Although there is still a need for improvement, cancer immunotherapy is regarded as a promising therapeutic modality. This book focuses on the preclinical development and evolving clinical landscape of cancer immunotherapy, encouraging synthetic organic/medicinal chemists, immunologists, and biologists to develop new, safe, and affordable treatments.
Immune Cell Lineage Reprogramming In Cancer
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Author : Jianmei Wu Leavenworth
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-22
Immune Cell Lineage Reprogramming In Cancer written by Jianmei Wu Leavenworth and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-22 with Medical categories.
Topic Editor Dr. Lewis Shi received financial support from Varian Medical System, Inc. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Genomics And Epigenomics Of Cancer Immunotherapy Challenges And Clinical Implications 3rd Edition
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Author : Xiao-Jie Lu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-31
Genomics And Epigenomics Of Cancer Immunotherapy Challenges And Clinical Implications 3rd Edition written by Xiao-Jie Lu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-31 with Science categories.
Cancer immunotherapy aims to activate, boost or normalize the immune system to attack cancer cells through natural mechanisms. The advent of immunotherapy is revolutionizing the treatment of many malignancies, especially hematological malignancies. However, there remain many hurdles to overcome for cancer immunotherapy to benefit the majority of patients. One of the main obstacles is how to alter the immunosuppressive tumor microenvironment so that immunotherapeutics can take effect. CD8+T cells are the main effector cells in anti-cancer immunity. However, the functionalities of CD8+T cells are often suppressed by the immunosuppressive tumor microenvironment, which is called T cell dysfunction. Dysfunctional T cells may display a reprogrammed epigenome such as aberrant DNA methylation. Moreover, the aberrant epigenomes of cancer cells and infiltrating immune cells may represent a cancer vulnerability. Increasing evidence supports the possibility of using genetic and/or epigenetic therapies to increase anti-tumor immunogenicity, increase tumor immune-infiltration, and to re-activate T cells. To investigate the genomic/epigenomic mechanisms that regulate CD8+ T cell differentiation and function may help to develop ways to delay or reverse T cell dysfunction, and thus to increase cancer immunotherapy efficacies. Besides T cells, macrophages, natural killer cells and dendritic cells as also participants and/or regulators in cancer immunotherapy. To explore the underlying epigenetic/genetic regulations of their functions will be of vital importance for the development of future cancer immunotherapies. Cancer immunotherapy will remain the hotspot in the years to come. This special issue aims at publishing high-quality original research as well as review articles on genomic/epigenomic aspects of cancer immunotherapy. Potential topics of interest include but are not limited to: 1. Explore the genetic/epigenetic regimens to increase anti-tumor immunogenicity, increase tumor immune-infiltration, and/or to re-activate anti-tumor immune cells. 2. Explore the mechanisms underlying functional genomics in T cell dysfunction and ways to delay/reverse it. 3. Development of pre-clinical models that facilitate the research of the genomics of human immunity. 4. Genetic/epigenetic explorations of cancer immunity that may translate to biomarkers for therapeutic efficacy monitoring and prognosis evaluation. 5. Elucidate the genetic basis for cancer immunotherapy combinations that may translate to the optimization of the latter
Molecular Strategies Aimed To Boost Nk Cell Based Immunotherapy Of Cancer
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Author : Loredana Cifaldi
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-31
Molecular Strategies Aimed To Boost Nk Cell Based Immunotherapy Of Cancer written by Loredana Cifaldi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with categories.
In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.
Innate Lymphocytes In Tumor Surveillance
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Author : Dagmar Stoiber
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-27
Innate Lymphocytes In Tumor Surveillance written by Dagmar Stoiber and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-27 with Medical categories.
Implications Of Immune Landscape In Tumor Microenvironment
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Author : Selvarangan Ponnazhagan
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-01
Implications Of Immune Landscape In Tumor Microenvironment written by Selvarangan Ponnazhagan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-01 with Medical categories.
Tumor microenvironment (TME) plays an important role in immunosuppressive mechanisms that result in immune editing and treatment resistance. Elucidating the diversity of stromal and immune cell distribution, polarization, and changes in their gene expression signatures will enable a better understanding of key events to improve treatment and prognosis. With the onset of immune checkpoint inhibitors (ICIs) in clinics for patients with solid tumors and hematologic malignancies, immunotherapy has taken a new direction in cancer management, especially as combination therapies. However, limitations encountered with the use of ICIs, including toxicity and immune-related adverse events (irAE) indicate the need to understand multiple regulatory mechanisms at both cellular and molecular levels that alter the immune landscape of the TME. Since predominant changes in the immune landscape occur at the TME, focussed deliberation on these events will provide a comprehensive understanding on this topic for scientists in the fields of basic, translational, and clinical cancer immunology. The heterogeneity of TME and complex immune landscape pose major challenges in the treatment of solid tumors. Thus, integrative approaches, which relate immune mechanisms in the TME to that of peripheral and systemic immune signatures are essential to improve our understanding of the disease complexity and possibly improve immunotherapy outcomes. Such multiparametric studies should combine advances in current understanding of cancer immunobiology with powerful technologies, such as single-cell and spatial transcriptomics, and high dimensional flow cytometry that rapidly expand our ability to explore these interactions. Notably, tumor heterogeneity and inflammatory mediators in the TME vary significantly in neoplasms based on mutational load, lymphocyte infiltration, expression of checkpoint molecules, soluble inhibitors, and tumor cell metabolism. Overall, connecting key events to immune signatures that conform to a consensus will provide a benchmark to delve further into this important topic. Other parameters such as myeloid and lymphoid cell polarization to alter the immune homeostasis at the TME, favoring a tumor-supportive milieu would provide a macroscopic picture that may help guide treatment choices for more refined personalized tumor immunotherapy.
Myeloid Derived Suppressor Cells As Disease Modulators
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Author : Olivera J. Finn
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-06
Myeloid Derived Suppressor Cells As Disease Modulators written by Olivera J. Finn and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-06 with categories.
Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous population of immature myeloid cells that can suppress the function of multiple immune cells and in particular, T cells, through various mechanisms. MDSCs can be divided into two major subtypes based on their cell surface phenotype and morphology: polymorphonuclear MDSC (PMN-MDSC or G-MDSC) and monocytic MDSC (M-MDSC). Additional subtypes have been proposed, such as the early MDSC (e-MDSC) that lack both macrophage and granulocyte markers. There is still considerable ambiguity about the phenotype of these cells that corresponds to their immunosuppressive function and there are on-going challenges on how to identify, purify and/or potentially generate and expand these cells in vitro. MDSCs were first discovered in cancer patients where they have been most extensively studied as components of the immunosuppressive tumor microenvironment. In the last several years, however, the importance of their immunomodulatory role in many other disease and clinical settings has emerged. Acknowledgments We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response
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Author : Petranel T. Ferrao
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-01
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response written by Petranel T. Ferrao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-01 with categories.
Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.