Nmr Principles And Applications To Biomedical Research
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Nmr Principles And Applications To Biomedical Research
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Author : Jay W. Pettegrew
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nmr Principles And Applications To Biomedical Research written by Jay W. Pettegrew and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Technology & Engineering categories.
Nuclear magnetic resonance (NMR) is having an enormous liTIpact on biomedical research both at the basic science and clinical levels. In order to appreciate the elegance and power of this technology a historical perspective is in order. In 1924 Pauli suggested that hydrogen nuclei might possess a magnetic IIlOlllent. This was in fact confinned by Rabbi in 1939 who demonstrated that a beam of hydrogen molecules in the presence of a magnetic field could be mutated by radio frequency fields resonating at the Iarmor frequency. 'Ihe first successful NMR experiments in condensed matter were independently conducted in late 1945 by Purcell, Torrey and PoUnd and by Bloch, Hansen and Packard. 'Ihe Purcell group detected proton NMR in solid paraffin and the Bloch group detected proton in liquid water. Bloch and Purcell received the Nobel Prize in physics in 1952 for these observations . Until about 1952, studies of liquids and solids with broad resonance lines dominated the field of NMR. However, the reports of 3 1 P NMR chemical shifts in several corrpounds in 1949 by Khight, of 14 N resonances in several ions by Proctor and Yu in 1950, and of 1 9 F resonances in several corrpounds in 1950 by Dickinson led to the development of high resolution NMR in Itquids. since the molecular motions in liquids result in very narrow lines compared to those in solids, :much smaller chemical shifts could be detected.
Nmr
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Author : Jay W. Pettegrew
language : en
Publisher:
Release Date : 1990-01
Nmr written by Jay W. Pettegrew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-01 with Imagerie par résonance magnétique categories.
Nmr Spectroscopy And Its Application To Biomedical Research
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Author : S.K. Sarkar
language : en
Publisher: Elsevier
Release Date : 1996-12-04
Nmr Spectroscopy And Its Application To Biomedical Research written by S.K. Sarkar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-12-04 with Science categories.
NMR has become the most diverse spectroscopic tool available to date in biomedical research. It is now routinely used to study biomolecular structure and dynamics particularly as a result of recent developments of a cascade of highly sophisticated multidimensional NMR pulse sequences, and of advances in genetic engineering to produce biomolecules, uniformly or selectively enriched with 13C, 15N and 2H. Features of this book: • Provides an up-to-date treatment of NMR techniques and their application to problems of biomedical interest • Most refined multidimensional pulse sequences including the basic aspects are covered by leading NMR spectroscopists. The book will be useful to NMR spectroscopists, biochemists, and to molecular biologists interested in the use of NMR techniques for solving biological problems.
Protein Nmr
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Author : Lawrence Berliner
language : en
Publisher: Springer
Release Date : 2015-08-24
Protein Nmr written by Lawrence Berliner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-24 with Science categories.
This book covers new techniques in protein NMR, from basic principles to state-of-the-art research. It covers a spectrum of topics ranging from a “toolbox” for how sequence-specific resonance assignments can be obtained using a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome. Further topics include the novel applications of Overhauser dynamic nuclear polarization methods (DNP), assessing protein structure, and aspects of solid-state NMR of macroscopically aligned membrane proteins. This book is an ideal resource for students and researchers in the fields of biochemistry, chemistry, and pharmacology and NMR physics. Comprehensive and intuitively structured, this book examines protein NMR and new novel applications that include the latest technological advances. This book also has the features of: • A selection of various applications and cutting-edge advances, such as novel applications of Overhauser dynamic nuclear polarization methods (DNP) and a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome • A pedagogical approach to the methodology • Engaging the reader and student with a clear, yet critical presentation of the applications
Structural Biology
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Author : Quincy Teng
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-06
Structural Biology written by Quincy Teng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-06 with Science categories.
This 2nd edition begins with an overview of NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.
Structural Biology
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Author : Quincy Teng
language : en
Publisher: Springer
Release Date : 2005-05-26
Structural Biology written by Quincy Teng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-26 with Science categories.
Over the years since NMR was first applied to solve problems in structural biology, it has undergonedramaticdevelopmentsinbothNMRinstrumenthardwareandmethodology. While it is established that NMR is one of the most powerful tools for understanding biological p- cesses at the atomic level, it has become increasingly difficult for authors and instructors to make valid decisions concerning the content and level for a graduate course of NMR in str- turalbiology. BecausemanyofthedetailsinpracticalNMRarenotdocumentedsystematically, students entering the field have to learn the experiments and methods through communication with other experienced students or experts. Often such a learning process is incomplete and unsystematic. This book is meant to be not only a textbook, but also a handbook for those who routinely use NMR to study various biological systems. Thus, the book is organized with experimentalists in mind, whether they are instructors or students. For those who have a little or no background in NMR structural biology, it is hoped that this book will provide sufficient perspective and insight. Those who are already experienced in NMR research may find new information or different methods that are useful to their research. Because understanding fundamental principles and concepts of NMR spectroscopy is essential for the application of NMR methods to research projects, the book begins with an introduction to basic NMR principles. While detailed mathematics and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR books, Chapter 1 illustrates some of the fundamental principles and concepts of NMR spectroscopy in a more descriptiveandstraightforwardmanner.
Nmr In Microbiology
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Author : Jean-Noël Barbotin
language : en
Publisher: Horizon Scientific Press
Release Date : 2000
Nmr In Microbiology written by Jean-Noël Barbotin and has been published by Horizon Scientific Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Science categories.
NMR is becoming an increasingly important technique in all areas of microbiological research. This book describes the theory and practical applications of NMR and is aimed specifically at microbiologists. Discover the value and potential and of this powerful technology. An invaluable reference source for all microbiologists!
Structural Biology
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Author : Quincy Teng
language : en
Publisher: Springer
Release Date : 2008-11-01
Structural Biology written by Quincy Teng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Science categories.
Over the years since NMR was first applied to solve problems in structural biology, it has undergonedramaticdevelopmentsinbothNMRinstrumenthardwareandmethodology. While it is established that NMR is one of the most powerful tools for understanding biological p- cesses at the atomic level, it has become increasingly difficult for authors and instructors to make valid decisions concerning the content and level for a graduate course of NMR in str- turalbiology. BecausemanyofthedetailsinpracticalNMRarenotdocumentedsystematically, students entering the field have to learn the experiments and methods through communication with other experienced students or experts. Often such a learning process is incomplete and unsystematic. This book is meant to be not only a textbook, but also a handbook for those who routinely use NMR to study various biological systems. Thus, the book is organized with experimentalists in mind, whether they are instructors or students. For those who have a little or no background in NMR structural biology, it is hoped that this book will provide sufficient perspective and insight. Those who are already experienced in NMR research may find new information or different methods that are useful to their research. Because understanding fundamental principles and concepts of NMR spectroscopy is essential for the application of NMR methods to research projects, the book begins with an introduction to basic NMR principles. While detailed mathematics and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR books, Chapter 1 illustrates some of the fundamental principles and concepts of NMR spectroscopy in a more descriptiveandstraightforwardmanner.
Nmr Data Handbook For Biomedical Applications
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Author : Paula T. Beall
language : en
Publisher: Pergamon
Release Date : 1984
Nmr Data Handbook For Biomedical Applications written by Paula T. Beall and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Biochemistry categories.
Spin Resonance Spectroscopy
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Author : Chandran Karunakaran
language : en
Publisher: Elsevier
Release Date : 2018-01-02
Spin Resonance Spectroscopy written by Chandran Karunakaran and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-02 with Science categories.
Spin Resonance Spectroscopy: Principles and Applications presents the principles, recent advancements and applications of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) in a single multi-disciplinary reference. Spin resonance spectroscopic techniques through NMR and EPR are widely used by chemists, physicists, biologists and medicinal chemists. This book addresses the need for new spin resonance spectroscopy content while also presenting the principles, recent advancements and applications of NMR and EPR simultaneously. Ideal for researchers and students alike, the book provides a single source of NMR and EPR applications using a dynamic, holistic and multi-disciplinary approach. Presents a highly interdisciplinary approach by including NMR and EPR applications in chemistry, physics, biology and biotechnology Addresses both NMR and EPR, making its concepts and applications implementable in multiple resonance environments and core scientific disciplines Features a broad range of methods, examples and illustrations for both NMR and EPR to aid in retention and underscore key concepts