Nobel Prizes Cancer Vision And The Genetic Code
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Nobel Prizes Cancer Vision And The Genetic Code
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Author : Erling Norrby
language : en
Publisher: World Scientific
Release Date : 2019-09-18
Nobel Prizes Cancer Vision And The Genetic Code written by Erling Norrby and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-18 with Science categories.
The present book discusses the Nobel Prizes in physiology or medicine 1966-68. The 1966 prize recognized that viruses may be involved in cancer formation. Later studies revealed that these kinds of infectious agents could pick up and transmit cellular genes of importance for regulation of cellular growth. It was then possible to recognize that many genes of this kind could be involved in the formation of cancer. The disease was found to represent the dark side of evolution. As a consequence of this insight new means of treatment fortunately have been developed.The rear parts of the eyes are extensions of the central nervous system. They have a fascinating intrinsic complexity, the neurophysiology and biochemistry of which has been progressively analyzed. These revealing studies concern both our capacity to distinguish different colors and also our possibility to see in the dark. The Prize in 1967 identified seminal contributions in this wide field by Ragnar Granit, Haldan Hartline and George Wald.The 1968 Prize is distinct in its recognition of Robert Holley, Ghobind Khorana and Marshall Nirenberg, who in different ways had contributed to the cracking of the genetic code. Insights into the language used by Nature, since the dawn of cellular life some 4.6 billion years ago, have completely revolutionized modern life sciences. The capacity to read and also to write the books of life has defined new kinds of science, deepening our understanding of the magic of evolution and opened the possibilities for molecular medicine by understanding the genetic background to diseases, not least cancer.Related Link(s)
Nobel Prizes Genes Viruses And Cellular Signaling
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Author : Erling Norrby
language : en
Publisher: World Scientific
Release Date : 2022-09-05
Nobel Prizes Genes Viruses And Cellular Signaling written by Erling Norrby and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-05 with Science categories.
The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products.The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of scientists. A number of the insights gained have been highlighted by Nobel Prizes in physiology or medicine. In 1970 the prize recognized Bernard Katz, Ulf von Euler and Julius Axelrod. They had revealed how signaling substances in the nerve terminals were stored in packages, released by membrane fusion and inactivated or reused by particular metabolic events.The recipient of the 1971 Nobel Prize in physiology or medicine was a single scientist, Earl Sutherland. He had identified critical molecules in cells that allow signals elicited at their surface via a number of internal steps to influence the expression of specific genes in the nucleus. The new kind of information transmitting molecules were referred to as 'secondary messengers'. They represent a critical part of a highly complex network of signaling controlling the operative conditions of the cell by adjustments of the so-called intermediary metabolism.The widening insights into functions of specialized cells and their complex interactions have led to the development of many kinds of remedies.
A Tale Of Two Viruses
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Author : Neeraja Sankaran
language : en
Publisher: University of Pittsburgh Press
Release Date : 2021-03-09
A Tale Of Two Viruses written by Neeraja Sankaran and has been published by University of Pittsburgh Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-09 with Science categories.
In 1965, French microbiologist André Lwoff was awarded the Nobel Prize in Physiology or Medicine for his work on lysogeny—one of the two types of viral life cycles—which resolved a contentious debate among scientists about the nature of viruses. A Tale of Two Viruses is the first study of medical virology to compare the history of two groups of medically important viruses—bacteriophages, which infect bacteria, and sarcoma agents, which cause cancer—and the importance of Lwoff’s discovery to our modern understanding of what a virus is. Although these two groups of viruses may at first glance appear to have little in common, they share uniquely parallel histories. The lysogenic cycle, unlike the lytic, enables viruses to replicate in the host cell without destroying it and to remain dormant in a cell’s genetic material indefinitely, or until induced by UV radiation. But until Lwoff’s discovery of the mechanism of lysogeny, microbiologist Félix d’Herelle and pathologist Peyton Rous, who themselves first discovered and argued for the viral identity of bacteriophages and certain types of cancer, respectively, faced opposition from contemporary researchers who would not accept their findings. By following the research trajectories of the two virus groups, Sankaran takes a novel approach to the history of the development of the field of medical virology, considering both the flux in scientific concepts over time and the broader scientific landscapes or styles that shaped those ideas and practices.
Nobel Prizes That Changed Medicine
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Author : Gilbert Thompson
language : en
Publisher: World Scientific
Release Date : 2012
Nobel Prizes That Changed Medicine written by Gilbert Thompson and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation''s website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise.
The Least Likely Man
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Author : Franklin H. Portugal
language : en
Publisher: MIT Press
Release Date : 2015-02-06
The Least Likely Man written by Franklin H. Portugal and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-06 with Biography & Autobiography categories.
How unassuming government researcher Marshall Nirenberg beat James Watson, Francis Crick, and other world-famous scientists in the race to discover the genetic code. The genetic code is the Rosetta Stone by which we interpret the 3.3 billion letters of human DNA, the alphabet of life, and the discovery of the code has had an immeasurable impact on science and society. In 1968, Marshall Nirenberg, an unassuming government scientist working at the National Institutes of Health, shared the Nobel Prize for cracking the genetic code. He was the least likely man to make such an earth-shaking discovery, and yet he had gotten there before such members of the scientific elite as James Watson and Francis Crick. How did Nirenberg do it, and why is he so little known? In The Least Likely Man, Franklin Portugal tells the fascinating life story of a famous scientist that most of us have never heard of. Nirenberg did not have a particularly brilliant undergraduate or graduate career. After being hired as a researcher at the NIH, he quietly explored how cells make proteins. Meanwhile, Watson, Crick, and eighteen other leading scientists had formed the “RNA Tie Club” (named after the distinctive ties they wore, each decorated with one of twenty amino acid designs), intending to claim credit for the discovery of the genetic code before they had even worked out the details. They were surprised, and displeased, when Nirenberg announced his preliminary findings of a genetic code at an international meeting in Moscow in 1961. Drawing on Nirenberg's “lab diaries,” Portugal offers an engaging and accessible account of Nirenberg's experimental approach, describes counterclaims by Crick, Watson, and Sidney Brenner, and traces Nirenberg's later switch to an entirely new, even more challenging field. Having won the Nobel for his work on the genetic code, Nirenberg moved on to the next frontier of biological research: how the brain works.
Competition Science Vision
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Author :
language : en
Publisher:
Release Date : 2009-11
Competition Science Vision written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11 with categories.
Competition Science Vision (monthly magazine) is published by Pratiyogita Darpan Group in India and is one of the best Science monthly magazines available for medical entrance examination students in India. Well-qualified professionals of Physics, Chemistry, Zoology and Botany make contributions to this magazine and craft it with focus on providing complete and to-the-point study material for aspiring candidates. The magazine covers General Knowledge, Science and Technology news, Interviews of toppers of examinations, study material of Physics, Chemistry, Zoology and Botany with model papers, reasoning test questions, facts, quiz contest, general awareness and mental ability test in every monthly issue.
Competition Science Vision
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Author :
language : en
Publisher:
Release Date : 2004-09
Competition Science Vision written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09 with categories.
Competition Science Vision (monthly magazine) is published by Pratiyogita Darpan Group in India and is one of the best Science monthly magazines available for medical entrance examination students in India. Well-qualified professionals of Physics, Chemistry, Zoology and Botany make contributions to this magazine and craft it with focus on providing complete and to-the-point study material for aspiring candidates. The magazine covers General Knowledge, Science and Technology news, Interviews of toppers of examinations, study material of Physics, Chemistry, Zoology and Botany with model papers, reasoning test questions, facts, quiz contest, general awareness and mental ability test in every monthly issue.
The Code Breaker
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Author : Walter Isaacson
language : en
Publisher: Simon and Schuster
Release Date : 2021-03-09
The Code Breaker written by Walter Isaacson and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-09 with Biography & Autobiography categories.
A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.
Cancer A Very Short Introduction
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Author : Nick James
language : en
Publisher: OUP Oxford
Release Date : 2011-05-26
Cancer A Very Short Introduction written by Nick James and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-26 with Medical categories.
In 1961 John F. Kennedy pledged to put a man on the moon by the end of the decade. Nine years later, Neil Armstrong and Buzz Aldrin walked on the moon. Ten years later, Richard Nixon echoed this pledge by declaring a 'war' on cancer. More than 30 years later, however, cancer remains one of the largest causes of death worldwide, with around 1 in 3 developing the disease. Curing cancer is not 'rocket science', but the question is, why has cancer proved to be harder to tackle than the moon landings turned out to be? Cancer research is a major economic activity. There are constant improvements in treatment techniques that result in better cure rates and increased quality and quantity of life for those with the disease, yet stories of breakthroughs in a cure for cancer are often in the media. In this Very Short Introduction Nick James, founder of the CancerHelp UK website, examines the trends in diagnosis and treatment of the disease, as well as its economic consequences. Asking what cancer is and what causes it, he considers issues surrounding expensive drug development, what can be done to reduce the risk of developing cancer, and the use of complementary and alternative therapies. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
How To Win The Nobel Prize
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Author : J. Michael BISHOP
language : en
Publisher: Harvard University Press
Release Date : 2009-06-30
How To Win The Nobel Prize written by J. Michael BISHOP and has been published by Harvard University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-30 with Science categories.
In 1989 Michael Bishop and Harold Varmus were awarded the Nobel Prize for their discovery that normal genes under certain conditions can cause cancer. In this book, Bishop tells us how he and Varmus made their momentous discovery. More than a lively account of the making of a brilliant scientist, How to Win the Nobel Prize is also a broader narrative combining two major and intertwined strands of medical history: the long and ongoing struggles to control infectious diseases and to find and attack the causes of cancer. Alongside his own story, that of a youthful humanist evolving into an ambivalent medical student, an accidental microbiologist, and finally a world-class researcher, Bishop gives us a fast-paced and engrossing tale of the microbe hunters. It is a narrative enlivened by vivid anecdotes about our deadliest microbial enemies--the Black Death, cholera, syphilis, tuberculosis, malaria, smallpox, HIV--and by biographical sketches of the scientists who led the fight against these scourges. Bishop then provides an introduction for nonscientists to the molecular underpinnings of cancer and concludes with an analysis of many of today's most important science-related controversies--ranging from stem cell research to the attack on evolution to scientific misconduct. How to Win the Nobel Prize affords us the pleasure of hearing about science from a brilliant practitioner who is a humanist at heart. Bishop's perspective will be valued by anyone interested in biomedical research and in the past, present, and future of the battle against cancer. Table of Contents: List of Illustrations Preface 1. The Phone Call 2. Accidental Scientist 3. People and Pestilence 4. Opening the Black Box of Cancer 5. Paradoxical Strife Notes Credits Index Reviews of this book: Despite his book's encouraging title, Bishop--who won a Nobel Prize in Physiology and Medicine in 1989--cautions that "I have not written an instruction manual for pursuit of the prize." Instead, he has written an amiable reflection on the experience of being a Nobelist, intertwined with some history and anecdotes about the award, and balanced by a wide-ranging review of his own career as an "accidental scientist"...Along the way, Bishop reflects on the history of our knowledge of microbes, cancer, the politics of funding research and present-day disenchantment with science. His main purpose in writing this book, Bishop says, is to show that "scientists are supremely human"--which he does with grace and charm. --Publishers Weekly Reviews of this book: How to Win the Nobel Prize is typical Bishop: modest, funny, insightful and offering an extremely clear and brief explanation of the basic scientific achievement that won the 1989 Nobel Prize in physiology or medicine for himself and longtime colleague, Harold Varmus, now president of the Memorial Sloan-Kettering Cancer Center. --David Perlman, San Francisco Chronicle Reviews of this book: In these pages Bishop reveals himself as a good writer blessed with enviable clarity, someone sensible and levelheaded who likes people and is enamored of his science. --John Tyler Bonner, New York Times Book Review Reviews of this book: This is a treasure...Above all, How to Win the Nobel Prize is a civilised book and a lavishly rewarding one. --Roy Herbert, New Scientist Reviews of this book: At its heart this analysis of science and the scientific world is a jewel. How to Win the Nobel Prize is an inspirational book, full of careful analysis and judgement. --John Oxford, Times Higher Education Supplement Reviews of this book: Bishop is a gifted communicator and teacher, and he sets about his task of educating scientists and the public by describing his career in science and science politics...In the end, Bishop's book provides a road map for scientists and the public to build a robust scientific community that serves our society well. --Andreas Trumpp and Daniel Kalman, Nature Cell Biology J. Michael Bishop has written his book 'to show that scientists are supremely human.' The book is also a lucid explanation of how science has been harnessed to fight the human afflictions of cancer and infectious disease. And the story ends with a wide-ranging overview of today's challenges to the scientific enterprise. Overall, a must-read for all those interested in science and scientists--even those with absolutely no interest in winning a Nobel Prize! --Bruce Alberts, President, National Academy of Sciences J. Michael Bishop is that rare scientist who is widely read in literature and poetry. Most importantly, he remembers what he reads and thinks deeply about it, as well as about all else in his rich life. The Nobel Prize he won and richly deserved, his political activism, his understanding of cancer and microbiology, his devotion to the practice of science--all these provide fodder for his writerly craft. Quite a wonderful book! --David Baltimore, Nobel Laureate and President, California Institute of Technology