Non Steroidal Anti Inflammatory Drugs Basis For Variability In Response
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Non Steroidal Anti Inflammatory Drugs Basis For Variability In Response
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Author : Brooks
language : en
Publisher: Agents and Actions Supplements
Release Date : 1985
Non Steroidal Anti Inflammatory Drugs Basis For Variability In Response written by Brooks and has been published by Agents and Actions Supplements this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Juvenile Nonfiction categories.
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs in the community. This reflects the high frequency of rheumatic complaints but may in part be due to the relative non efficacy of these drugs. Since the introduction of ibuprofen, the first new NSAID to compete with aspirin, phenylbutazone and indomethacin, there has been a proliferation of new NSAIDs of differing chemical classes but an apparent similar spectrum of action. Despite the fact that these drugs are thought to work by an apparent common mechanism of action (suppression of prostaglandin synthetase activity) continued development of these drugs occurs. There exists at present a conflict between the pharmaceutical industry with its attempts to introduce new NSAIDs and drug regulatory authorities who are generally not convinced of the need for additional drugs of_ this class. The practising clinician regards a variety of NSAIDs as necessary to enable pain relief to be optimised.with minimal adverse effects. With respect to the dilemma of how many NSAIDs are really necessary surprisingly little convincing data is available to assist in resolving this issue. It was therefore decided to hold a satellite meeting to the XVIth International League Against Rheumatism Conference in May 1985.
Basis For Variability Of Response To Anti Rheumatic Drugs
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Author : Peter M. Brooks
language : en
Publisher: Birkhauser
Release Date : 1988
Basis For Variability Of Response To Anti Rheumatic Drugs written by Peter M. Brooks and has been published by Birkhauser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Antirheumatic agents categories.
Basis For Variability Of Response To Anti Rheumatic Drugs
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Author : P. Brooks
language : en
Publisher: Birkhäuser
Release Date : 1988-10-01
Basis For Variability Of Response To Anti Rheumatic Drugs written by P. Brooks and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-10-01 with Science categories.
Since the rheumatic diseases are among the most prevalent of conditions, the anti-rheumatic drugs make up one of the largest groups of drugs prescribed. They vary from the non-steroidal anti-inflammatory drugs through to the complex imrnunomodulators. There are significant differences between these groups of drugs as regards their mechanism of action and within each spectrum of adverse reactions, yet there is also some overlap. class there are also subtle individual differences between the drugs despite a sharing of the basic mechanisms of action and range of side effects. It is this individual variation and, in particular, the individual reaction of the patient to the drug that we attempted to address at this symposium. The first symposium on Individual Variation in Response to Non Steroidal Anti-inflammatory Drugs was held at Leura, New South Wales, Australia as a satellite symposium to the XVI International Congress of Rheumatology in August, 1985. Following a successful meeting, proceedings of which were published in a supplement to Agents and Actions (Suppl. 17, 1986), it was decided to organise a second symposium as a satellite meeting of the International Congressof Pharmacology Meeting in Sydney, August, 1987. The meeting was held at the Manly Pacific and focused on variability in response to anti-rheumatic drugs in general rather than just concentrating on the non-steroidal drugs.
Basis For Variability Of Response To Anti Rheumatic Drugs
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Author : P. Brooks
language : en
Publisher: Birkhäuser
Release Date : 2014-01-14
Basis For Variability Of Response To Anti Rheumatic Drugs written by P. Brooks and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-14 with Science categories.
Since the rheumatic diseases are among the most prevalent of conditions, the anti-rheumatic drugs make up one of the largest groups of drugs prescribed. They vary from the non-steroidal anti-inflammatory drugs through to the complex imrnunomodulators. There are significant differences between these groups of drugs as regards their mechanism of action and within each spectrum of adverse reactions, yet there is also some overlap. class there are also subtle individual differences between the drugs despite a sharing of the basic mechanisms of action and range of side effects. It is this individual variation and, in particular, the individual reaction of the patient to the drug that we attempted to address at this symposium. The first symposium on Individual Variation in Response to Non Steroidal Anti-inflammatory Drugs was held at Leura, New South Wales, Australia as a satellite symposium to the XVI International Congress of Rheumatology in August, 1985. Following a successful meeting, proceedings of which were published in a supplement to Agents and Actions (Suppl. 17, 1986), it was decided to organise a second symposium as a satellite meeting of the International Congressof Pharmacology Meeting in Sydney, August, 1987. The meeting was held at the Manly Pacific and focused on variability in response to anti-rheumatic drugs in general rather than just concentrating on the non-steroidal drugs.
Variability In Response To Anti Rheumatic Drugs
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Author : Peter M. Brooks
language : en
Publisher: Birkhäuser
Release Date : 1993-07
Variability In Response To Anti Rheumatic Drugs written by Peter M. Brooks and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-07 with Juvenile Nonfiction categories.
Therapy of rheumatiod arthritis is undergoing dramatic chamges. Greater appreciation of the long-term outcomes of this disease and the impacts of treatments has resulted in a more aggressive approach to therapy, especially in the early stages.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1995
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medicine categories.
New Developments In Antirheumatic Therapy
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Author : K. D. Rainsford
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
New Developments In Antirheumatic Therapy written by K. D. Rainsford and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
At present we may be at the cross-roads in the therapeutic approaches we have for the treatment of the 100 or more rheumatic conditions. This is be cause we now recognise that although some advances have been made with the development of a large range of non-steroidal and steroidal drugs during the past two decades or so, we now recognise that many, if not all, of these have rather limited effects on many of the disease processes which underlie the manifestations of the various rheumatic states. Advances in molecular bi- 010gy in the past 5-10 years have enabled these tools to be applied extensive ly for developing further our understanding of the rheumatic disease processes. In some cases these molecular tools (e. g. ,),-interferon, interleukin- 2, T-cell antibodies) have been directly employed as therapies themselves. While the outcome from trials with such agents in rheumatoid arthritis in particular has not been as would have been hoped, these results as with cy closporin A and low-dose methotrexate in the therapy of rheumatoid arth ritis have given us important indications for the approach employing what are generally described as "immunomodulators" to control this disease. But this may not be the same type of approach which is desirable for all types of rheumatic conditions. Indeed, even the way which the present range of drugs and other therapies are applied may not be the most effective and safe means of treating different types of arthritic conditions.
National Library Of Medicine Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date :
National Library Of Medicine Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medicine categories.
Ibuprofen
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Author : K. D. Rainsford
language : en
Publisher: John Wiley & Sons
Release Date : 2015-09-08
Ibuprofen written by K. D. Rainsford and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-08 with Medical categories.
Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.
Advances In Anti Rheumatic Therapy
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Author : Kim D. Rainsford
language : en
Publisher: CRC Press
Release Date : 1995-12-11
Advances In Anti Rheumatic Therapy written by Kim D. Rainsford and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-12-11 with Medical categories.
This work on advances in anti-rheumatic therapy covers topics such as: outcome measures in clinical trials of anti-rheumatic drugs; azapropazone (AZP); the mode of action of glucocorticoids; and clinical trials of oral chondroitin sulphate in the treatment of osteoarthritis.