Novel Approaches To Studying Basal Ganglia And Related Neuropsychiatric Disorders
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Novel Approaches To Studying Basal Ganglia And Related Neuropsychiatric Disorders
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Author : XIAO-HONG LU
language : en
Publisher: Academic Press
Release Date : 2009-11-06
Novel Approaches To Studying Basal Ganglia And Related Neuropsychiatric Disorders written by XIAO-HONG LU and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-06 with Science categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.
The Basal Ganglia
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Author : Jean-Jacques Soghomonian
language : en
Publisher: Springer
Release Date : 2016-11-04
The Basal Ganglia written by Jean-Jacques Soghomonian and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-04 with Psychology categories.
This groundbreaking text takes current knowledge of the basal ganglia far from well-known motor-based models to a more inclusive understanding of deep-brain structure and function. Synthesizing diverse perspectives from across the brain-behavioral sciences, it tours the neuroanatomy and circuitry of the basal ganglia, linking their organization to their controlling functions in core cognitive, behavioral, and motor areas, both normative and disordered. Interactions between the basal ganglia and major structures of the brain are identified in their contributions to a diverse range of processes, from language processing to decision-making, emotion to visual perception, motivation to intent. And the basal ganglia are intimately involved in the mechanisms of dysfunction, as evinced by chapters on dyskinesia, Parkinson’s disease, neuropsychiatric conditions, and addictions. Included in the coverage: Limbic-basal ganglia circuits: parallel and integrative aspects. Dopamine and its actions in the basal ganglia system. Cerebellar-basal ganglia interactions. The basal ganglia contribution to controlled and automatic processing. The basal ganglia and decision making in neuropsychiatric disorders. The circuitry underlying the reinstatement of cocaine seeking: modulation by deep brain stimulation. The basal ganglia and hierarchical control in voluntary behavior. Its breadth and depth of scholarship and data should make The Basal Ganglia a work of great interest to cognitive psychologists and neuroscientists, neuropsychologists, neurologists, neuropsychiatrists, and speech-language pathologists.
The Brain And Behavior
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Author : David L. Clark
language : en
Publisher: Cambridge University Press
Release Date : 2005-09-08
The Brain And Behavior written by David L. Clark and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-08 with Medical categories.
New edition building on the success of previous one. Retains core aim of providing an accessible introduction to behavioral neuroanatomy.
Psychiatry
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Author : Rebecca McKnight
language : en
Publisher: Oxford University Press, USA
Release Date : 2019
Psychiatry written by Rebecca McKnight and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Mental illness categories.
Revised edition of: Psychiatry / Michael Gelder, Richard Mayou, John Geddes. 4th edition c2012.
The Hidden Life Of The Basal Ganglia
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Author : Hagai Bergman
language : en
Publisher: MIT Press
Release Date : 2021-10-12
The Hidden Life Of The Basal Ganglia written by Hagai Bergman and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-12 with Science categories.
The anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values. The main task of the basal ganglia—a group of subcortical nuclei, located at the base of the brain—is to optimize and execute our automatic behavior. In this book, Hagai Bergman analyzes the anatomy and physiology of the basal ganglia, discussing their relation to brain and behavior, to disorders and therapies, and even to moral values. Drawing on his forty years of studying the basal ganglia, Bergman presents new information on physiology and computational models, Parkinson’s disease and other ganglia-related disorders, and such therapies as deep brain stimulation. Focusing on studies of nonhuman primates and human basal ganglia and relying on system physiology and in vivo extra-cellular recording techniques, Bergman first describes the major brain structures that constitute the basal ganglia, the morphology of their cellular elements, their synaptic connectivity and their physiological function in health and disease. He discusses the computational physiology of the healthy basal ganglia, describing four generations of computational models, and then traces the computational physiology of basal ganglia–related disorders and their treatments, including Parkinson’s disease and its pharmacological and surgical therapies. Finally, Bergman considers the implications of these findings for such moral concerns as free will. Explaining this leap into domains rarely explored in neuroscientific accounts, Bergman writes that the longer he studies the basal ganglia, the more he is convinced that they are truly the base of both brain and mind.
Clinical Neuroanatomy
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Author : John Mendoza
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-26
Clinical Neuroanatomy written by John Mendoza and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-26 with Psychology categories.
Clinical Neuroanatomy offers an extensive review of higher cortical – behavioral functions and their anatomical substrates. The book begins with a review of the basic internal and external morphology, major nerve and fiber tracts, behavioral correlates, and clinical syndromes associated with spinal cord, brain stem, and cerebellum, reacquainting readers with the functional anatomy of the subtentorial central nervous system. The central chapters offer more detailed, integrated, and, at times, theoretical models of cortical systems and their internal organization. Additional chapters highlight vascular anatomy and neurochemical systems. Nearly 300 illustrations help identify key structures and pathways, as well as providing clinical and pathological examples.
Insights In Pediatric Neurology 2021
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Author : Hong Ni
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
Insights In Pediatric Neurology 2021 written by Hong Ni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Medical categories.
Understanding Neuropsychiatric Disorders
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Author : Martha E. Shenton
language : en
Publisher: Cambridge University Press
Release Date : 2010-12-09
Understanding Neuropsychiatric Disorders written by Martha E. Shenton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-09 with Medical categories.
An informative and comprehensive review from the leading researchers in the field, this book provides a complete one-stop guide to neuroimaging techniques and their application to a wide range of neuropsychiatric disorders. For each disorder or group of disorders, separate chapters review the most up-to-date findings from structural imaging, functional imaging and/or molecular imaging. Each section ends with an overview from a internationally-renowned luminary in the field, addressing the question of 'What do we know and where are we going?' Richly illustrated throughout, each chapter includes a 'summary box', providing readers with explicit take-home messages. This is an essential resource for clinicians, researchers and trainees who want to learn how neuroimaging tools lead to new discoveries about brain and behaviour associations in neuropsychiatric disorders.
The Frontal Lobes And Neuropsychiatric Illness
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Author : Stephen P. Salloway
language : en
Publisher: American Psychiatric Pub
Release Date : 2008-11-01
The Frontal Lobes And Neuropsychiatric Illness written by Stephen P. Salloway and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Medical categories.
This exciting volume brings together the latest work of 26 recognized experts in clinical neuropsychiatry, neuropsychology, neuroscience, and neuroimaging. Its chapters are organized into sections that cover a broad range of topics related to advances in our understanding of normal and abnormal frontal lobe functions. Part 1 introduces frontal lobe dysfunction as a common pathway leading to social and occupational disability, arguing that our aging population with its decline in executive cognitive abilities mandates corresponding eligibility and treatment changes in public and private health disability policies. Part 2 delineates the anatomy and neurochemistry of the extended frontal systems underlying neuropsychiatric illness, including colorful illustrations of three key prefrontal-subcortical circuits; a description of the functional anatomy of the orbitofrontal cortex and its relationship to obsessive-compulsive disorder (OCD); the intricate pharmacology of working memory systems and how they apply to schizophrenia; the lateralization of prefrontal cognitive functions; and a framework for understanding the role played by the prefrontal cortex in consciousness and self-awareness. Part 3 clarifies the overused diagnosis "frontal lobe syndrome" seen in clinical practice, identifying three prefrontal syndromes for further study -- dorsolateral dysexecutive syndrome, orbitofrontal disinhibited syndrome, and mesial frontal apathetic syndrome -- that align with the anatomical systems described in Part 2 of this volume. Also included are common problems -- and suggested solutions -- in diagnosis and treatment, a practical overview of the assessment of frontal lobe functions with guidelines for bedside and formal neuropsychological examination, and comprehensive treatment strategies. Part 4 covers the role of the frontal lobes in major neuropsychiatric illnesses, discussing evidence that shows prefrontal and anterior temporal hypometabolism in primary and secondary depression; reviewing anatomical, imaging, and neurochemical studies in schizophrenia; describing the neuropsychological and neuropsychiatric sequelae of closed head injury; summarizing the neurological substrates related to interesting and often dramatic cases of content-specific delusions; and concluding with a report on the stereotactic neurosurgical treatment of refractory OCD and its implications for understanding frontal lobe function. This remarkable work is intended for psychiatrists, neurologists, psychologists, basic and clinical neuroscientists, and trainees from each of these disciplines, who will welcome it as a valuable tool in understanding the complexities of what was once considered the terra incognita of the brain.
The Neurobiology And Genetics Of Gilles De La Tourette Syndrome New Avenues Through Large Scale Collaborative Projects
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Author : Peristera Paschou
language : en
Publisher: Frontiers Media SA
Release Date : 2018-03-13
The Neurobiology And Genetics Of Gilles De La Tourette Syndrome New Avenues Through Large Scale Collaborative Projects written by Peristera Paschou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-13 with categories.
Gilles de la Tourette Syndrome (TS) is a common, albeit severely under-diagnosed, neuropsychiatric disorder that is caused by a complex genetic basis, interacting with environmental factors. High comorbidity rates with other neurodevelopmental disorders such as attention deficit/hyperactivity disorder and obsessive compulsive disorder raise the intriguing hypothesis of a shared etiological background. Abnormalities of corticostriatal-thalamic-cortical circuits (CSTC) and dysfunction of both dopamine and serotonin neurotransmitter systems are assumed to be associated with TS. Recently, multiple lines of evidence also point towards an important role of additional neurotransmitters such as histamine and glutamate. For a very long time, efforts to elucidate the etiology and pathophysiology of TS have been fragmented and hampered by low statistical power. Finally, after more than two decades of active research aiming to identify the etiology and pathophysiology of TS, we are on the verge of a new era, promising exciting and rapid discoveries in the field. Investigators from around the world, representing multiple disciplines and scientific approaches, are joining their efforts in large-scale initiatives supported both by European Union and US National funding agencies, such as the European-funded EMTICS, TACTICS, and TSGeneSEE consortia, the Marie Curie Initial Training Network TS-EUROTRAIN and the European Society for the Study of TS joining forces with the NIH-funded TSAICG, GGRI, and Tic Genetics consortia. Importantly, all these initiatives are supported by TS patient support and advocacy groups. Multiple resources are being consolidated and coming together to serve the study of TS, including large well-characterized patient cohorts, and specialized epidemiological databases, such as the unique resource of the Netherlands Twin Register. This research topic showcases current large-scale collaborative efforts aiming to elucidate the genetic and neurobiological background of TS, through diverse approaches; from genomewide association studies aiming to identify common variants associated to the disorder to neuroimaging studies and animal models. Furthermore, current approaches on the clinical assessment and management of the disorder are presented. Propelled by the gradual availability of large scale TS cohorts, novel methodologies, and importantly, sheer enthusiasm by multiple researchers working together across different countries, the new era of the neurobiology of TS holds the promise to identify novel targets for improved therapies.