Novel Fabrication And Operation Of Integrated Silicon Nanowire Field Effect Biosensors For Reliable Detection Of Cancer Prognostic Biomarkers
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Novel Fabrication And Operation Of Integrated Silicon Nanowire Field Effect Biosensors For Reliable Detection Of Cancer Prognostic Biomarkers
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Author : Duy Phu Tran
language : en
Publisher:
Release Date : 2014
Novel Fabrication And Operation Of Integrated Silicon Nanowire Field Effect Biosensors For Reliable Detection Of Cancer Prognostic Biomarkers written by Duy Phu Tran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Biochemical markers categories.
Owning to their unique physicochemical properties, one-dimensional silicon nanowire field effect transistors (SiNW FETs) are widely considered as one of the most promising solid state sensing technology towards the development of ultrasensitive and label-free bio diagnostic devices. While a number of recent studies have focussed on either the investigation of silicon nanowires' structure-function or the demonstration of their capabilities in model studies, integrated and systematic approaches towards their translational implementation as bio-diagnostic sensing technology in clinical environment remains scarce. The ultimate aim of this research was therefore to advance the technology and knowledge of SiNW FET molecular sensing devices through a cross-disciplinary approach combining nanofabrication, nano-electronics, molecular biosensing and clinical oncology.
Semiconductor Electronic Label Free Assay Selfa With Novel Nanowire Field Effect Transistor Biosensors
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Author : Yufei Mao
language : en
Publisher:
Release Date : 2016
Semiconductor Electronic Label Free Assay Selfa With Novel Nanowire Field Effect Transistor Biosensors written by Yufei Mao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Biomolecular assays are biochemical tests used for quantitative measurement of target biomolecular analytes from specimens. This is usually achieved with labelling techniques where target biomolecules were conjugated with labels for signal readout. Label-free assay provides an alternative route to detect target biomolecules without secondary label conjugation. The technique enables high-throughput and real-time measurements of analyte samples which is of primary significance in many biological applications (e.g. drug screening, point-of-care diagnosis). One promising candidate for real-time label-free biomolecular detection is using field-effect transistor (FET) biosensors. A FET without a gate electrode is designed to detect immunological antigen-antibody binding reactions. Charged target biomolecules are bound with specificity onto biological receptors anchored on the oxide dielectric surface. The induced electric field mediated by oxide dielectric is directly translated into current change without any labeling. Nanowire FET (nwFET) biosensors have been demonstrated to have exceptional biomolecule sensitivity with lower limit of detection (LLOD) down to sub-picomolar range. However, the inherently low output-signal levels are impractical for their use outside of the research lab. In addition, variability issues originated from device fabrication, system integration and during sensing experiment prohibit reliable quantitation of target biomolecules in the scenarios of interest. As a result, label-free biomolecular assays have not been meaningfully adopted and impacted the biomedical and pharmaceutical industry even after decades of intense research. To boost output signal level of FET sensors, we previously proposed a novel T-shape nwFET (T-nwFET) structure by itself as an integrated sensor-amplifier to amplify output signals at close proximity. However, the concept of T-nwFET as a biosensor has not been implemented in biomolecular detections. In this work, we first understood and improved the sensitivity of T-nwFET biosensors using a signal-to-noise ratio metric, and validated the performance in practical settings. We also investigated theoretical and practical approaches to improve selectivity, which is crucial for accurate quantitation of biomolecules. We proposed a novel per-sensor based calibration scheme to mitigate device-to-device and test-to-test variability. We then developed the T-nwFET into a holistic biomolecular assay platform, SELFA, and its performance was evaluated by implementations in predictive toxicology and clinical studies.
Study Of Silicon Nanowire Field Effect Transistor For Analog And Digital Biosensing
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Author : Pengyuan Zang
language : en
Publisher:
Release Date : 2017
Study Of Silicon Nanowire Field Effect Transistor For Analog And Digital Biosensing written by Pengyuan Zang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Biosensors categories.
The advancement of semiconductor technology has popularized the low power, economical and small form-factor solid state devices, such as those highly integrated and interconnected as the fundamental infrastructure for the internet of things (IoT). Due to its CMOS-compatibility and electrical interface, the biosensor utilizing field effect transistor (FET) as transducer has become the perfect candidate to interface directly with the chemical and biological properties of the physical world. Especially, nanowire (NW) FET biosensor has received great attention as a highly sensitive biosensing platform, benefiting from its increased surface-to-volume ratio. In this work, several challenges and key aspects of existing NW FET biosensor were studied, and solutions were proposed to address these problems. For example, the hydrolytic stability of the surface sensing element was evaluated and improved by a hydrolysis process, which led to a significant increase in the overall biosensor performance. Another challenge is the noise in the electric potential of the sensing solutions. A secondary reference electrode was introduced in the biosensing system, and its potential was used to subtract the noise from the measured sensor output. Compared to a reference FET, this approach greatly reduced the system complexity and requirement, yet still improved the limit of detection (LOD) by 50 – 70%. This work also involved careful investigation into the analyte sensitivity, which can be considerably affected by the charge buffering effect from the surface hydroxyl groups. Analytical studies and numerical simulations were carried out, revealing that both low pH sensitivity and large analyte buffer capacity are required to achieve a reasonable analyte sensitivity. The most significant portion of this work was the experimental demonstration of the digital biosensing concept with single serpentine NW FET biosensor. The majority of existing FET biosensors utilized the device as an analog transducer, which measures the captured analyte density to generate an output, and suffers from various noise factors, especially the nonspecific changes of the sensing solutions than cannot be reduced by averaging. Digital biosensor no longer depends on the amplitude of the sensor output and is therefore better immune from these noise factors. Instead, the individual binding event of single analyte is counted and analyzed statistically to determine the analyte concentration. The single serpentine NW FET is the ideal device design to achieve digital biosensing. It maintains the low noise level with the equivalently long channel, yet achieves a small footprint enough for binding of only a single analyte. The binding of analyte to multiple segments of the NW results in both higher sensitivity and binding avidity. The small footprint also enables high integration density of the individual digital biosensors into an array format, which is a responsive, highly sensitive, and cost-effective future biosensing platform.
Biosensors
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-05-05
Biosensors written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-05 with Medical categories.
This book covers novel and current strategies for biosensing, from the use of nanomaterials and biological functionalized surfaces to the mathematical assessment of novel biosensors and their potential use as wearable devices for continuous monitoring. Biosensing technologies can be used in the medical field for the early detection of disease, monitoring effectiveness of treatments, detecting nervous system signals for controlling robotic prosthesis, and much more. This book includes eleven chapters that examine and discuss several strategies of biosensing, proposing mathematical designs that address the latest reported technologies.
Development Of Novel Silicon Nanowire Biosensor For Detection Of Dna Molecules At Femtomolar Concentration
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Author : Mohammad Nuzaihan Md Nor
language : en
Publisher:
Release Date : 2016
Development Of Novel Silicon Nanowire Biosensor For Detection Of Dna Molecules At Femtomolar Concentration written by Mohammad Nuzaihan Md Nor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
The scopes of this research are divided into four main parts. The first research scope is initiated by reviewing the theoretical aspects related to nanotechnology, biosensor, nanowire, fabrication methods of silicon nanowire and its applications. Literature review serves as an integral part in ensuring the success of a present research. Thus, this review induces well-directed progression in achieving the research objectives.
Nanowires
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Author : Anqi Zhang
language : en
Publisher: Springer
Release Date : 2016-07-26
Nanowires written by Anqi Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-26 with Technology & Engineering categories.
This book provides a comprehensive summary of nanowire research in the past decade, from the nanowire synthesis, characterization, assembly, to the device applications. In particular, the developments of complex/modulated nanowire structures, the assembly of hierarchical nanowire arrays, and the applications in the fields of nanoelectronics, nanophotonics, quantum devices, nano-enabled energy, and nano-bio interfaces, are focused. Moreover, novel nanowire building blocks for the future/emerging nanoscience and nanotechnology are also discussed.Semiconducting nanowires represent one of the most interesting research directions in nanoscience and nanotechnology, with capabilities of realizing structural and functional complexity through rational design and synthesis. The exquisite control of chemical composition, morphology, structure, doping and assembly, as well as incorporation with other materials, offer a variety of nanoscale building blocks with unique properties.
Silicon Nanowire Field Effect Transistor For Biosensing
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Author : Yu Chen
language : en
Publisher:
Release Date : 2009
Silicon Nanowire Field Effect Transistor For Biosensing written by Yu Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Abstract: Detection and recognition of chemical ions and biological molecules are important in basic science as well as in pharmacology and medicine. Nanotechnology has made it possible to greatly enhance detection sensitivity through the use of nanowires, nanotubes, nanocrystals, nanocantilevers, and quantum dots as sensing platforms. In this work silicon nanowires are used as the conductance channel between the source and drain of a FET (field effect transistor) device and the biomolecular binding on the surface of nanowire modifies the conductance like a change in gate voltage. Due to the high surface-to-volume ratio and unique character of the silicon nanowires, this device has significant advantages in real-time, label-free and highly sensitive detection of a wide range of species, including proteins, nucleic acids and other small molecules. Here we present a biosensor fabricated from CMOS (complementary metal-oxide-semiconductor) compatible top-down methods including electron beam lithography. This method enables scalable manufacturing of multiple sensor arrays with high efficiency. In a systematic study of the device characteristics with different wire widths, we have found the sensitivity of the device increases when wire width decreases. By operating the device in appropriate bias region, the sensitivity of the device can be improved without doping or high temperature annealing. Not only can this device be used to detect the concentration of proteins and metabolites like urea or glucose, but also dynamic information like the dissociation constant can be extracted from the measurement. The device is also used to detect the clinically related cancer antigen CA 15.3 and shows potential application in cancer studies.
Electrochemical Biosensors
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Author : Serge Cosnier
language : en
Publisher: CRC Press
Release Date : 2015-01-26
Electrochemical Biosensors written by Serge Cosnier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-26 with Science categories.
Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Nanowire Field Effect Transistors Principles And Applications
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Author : Dae Mann Kim
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-23
Nanowire Field Effect Transistors Principles And Applications written by Dae Mann Kim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-23 with Technology & Engineering categories.
“Nanowire Field Effect Transistor: Basic Principles and Applications” places an emphasis on the application aspects of nanowire field effect transistors (NWFET). Device physics and electronics are discussed in a compact manner, together with the p-n junction diode and MOSFET, the former as an essential element in NWFET and the latter as a general background of the FET. During this discussion, the photo-diode, solar cell, LED, LD, DRAM, flash EEPROM and sensors are highlighted to pave the way for similar applications of NWFET. Modeling is discussed in close analogy and comparison with MOSFETs. Contributors focus on processing, electrostatic discharge (ESD) and application of NWFET. This includes coverage of solar and memory cells, biological and chemical sensors, displays and atomic scale light emitting diodes. Appropriate for scientists and engineers interested in acquiring a working knowledge of NWFET as well as graduate students specializing in this subject.
Advanced Biosensors For Health Care Applications
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Author : Dr. Inamuddin
language : en
Publisher: Elsevier
Release Date : 2019-06-15
Advanced Biosensors For Health Care Applications written by Dr. Inamuddin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-15 with Technology & Engineering categories.
Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. Describes advanced nanomaterials for biosensor applications Relates the properties of available nanomaterials to specific biomarkers applications Includes diagnosis and electrochemical studies based on biosensors Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies Describes novel strategies for developing a new class of assay systems to retrieve the desired health information