Novel Insights Into The Pathophysiology Of Diabetesrelated Complications Implications For Improved Therapeutic Strategies Volume Ii

DOWNLOAD

Download Novel Insights Into The Pathophysiology Of Diabetesrelated Complications Implications For Improved Therapeutic Strategies Volume Ii PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Novel Insights Into The Pathophysiology Of Diabetesrelated Complications Implications For Improved Therapeutic Strategies Volume Ii book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Novel Insights Into The Pathophysiology Of Diabetesrelated Complications Implications For Improved Therapeutic Strategies Volume Ii

DOWNLOAD
Author : Jian Ma
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-30

Novel Insights Into The Pathophysiology Of Diabetesrelated Complications Implications For Improved Therapeutic Strategies Volume Ii written by Jian Ma and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-30 with Medical categories.

Given that Volume I of the topic Novel Insights into the Pathophysiology of Diabetes-related Complications: Implications for Improved Therapeutic Strategies has been successfully performed last year, and we have received submissions talking about diabetic retinopathy (DR), diabetic neuropathy (DN), type 2 diabetes mellitus (T2DM)-associated periodontitis, diabetic oxidative liver damage, diabetic-related wound healing, etc. We are pleased to announce the launch of Volume II. Diabetes mellitus (DM), as a major health problem, has been highly prevalent across the globe. It is increasingly apparent that not only a cure for the current worldwide diabetes epidemic is required, but also a cure for its major complications, including heart disease, chronic kidney disease, and nerve damage. In addition, other problems with feet, oral health, vision, hearing, reproduction, and mental health need to be explored as well. Understanding the underlying mechanisms of these diabetic complications would be helpful to prevent or delay the occurrence of complications and to improve the overall health condition of people with DM. Unfortunately, current therapies only slow down disease deterioration of most prevalent diabetic complications. Indeed, whether the mechanisms in diabetic complications are protective or pathological remains not fully defined, based on the impacts during the underlying disease process. Thus, we welcome academic articles that can provide the latest insights into the pathophysiology of diabetes-related complications. These submissions range from uncovering the intracellular signaling pathways with the development of diabetic complications, to exploring the possible role of genetic issues, metabolic regulation, and inflammation mechanisms. We welcome high-quality Original Research and Review articles that contribute to the mechanism investigation of a range of diabetic complications, including but not limited to: • Microvascular damage-related diseases in diabetic patients, such as neuropathy, nephropathy, and retinopathy; • Foot damage and skin problems in diabetes; • Reproductive disorder in diabetic women; • The relationship between diabetes and the development of Alzheimer's disease, depression, and cognitive impairment. In this continued Volume II, we are looking forward to seeing many more academic articles on DM-related heart disease, a reproductive disorder in diabetic women or the relationship between diabetes and the development of Alzheimer’s disease, etc. Also, Methods articles that introduce novel experimental methods or animal models that contribute to understanding the formation and progress of diabetic complications are continually welcome. Opinions or Perspectives regarding the implications of new research on the treatment of diabetic complications are encouraged too.

Novel Insights Into The Pathophysiology Of Diabetes Related Complications Implications For Improved Therapeutic Strategies

DOWNLOAD
Author : Jian Ma
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-30

Novel Insights Into The Pathophysiology Of Diabetes Related Complications Implications For Improved Therapeutic Strategies written by Jian Ma and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-30 with Medical categories.

Insight Into Diabetes Related Macular Edema A Holistic Approach To Understanding Managing And Thriving

DOWNLOAD
Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2025-03-12

Insight Into Diabetes Related Macular Edema A Holistic Approach To Understanding Managing And Thriving written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-12 with Medical categories.

Dive into the comprehensive guide, 'Insight into Diabetes-Related Macular Edema: A Holistic Approach to Understanding, Managing, and Thriving', offering in-depth exploration of this vision-threatening complication of diabetes. From elucidating the pathophysiology to unveiling emerging therapeutic targets, each chapter delves into critical aspects, including nutrition, pharmacotherapy, and community engagement. With meticulous detail, this treatise navigates through the complexities of DRME, empowering readers with knowledge on holistic interventions, traditional medicine practices, and social support networks. Seamlessly blending medical expertise with a holistic perspective, this guide serves as a beacon for healthcare professionals, patients, and caregivers alike. Discover evidence-based insights, practical recommendations, and actionable strategies to optimize care, enhance quality of life, and foster resilience in the face of DRME challenges. Embrace a journey of understanding, empowerment, and hope with this invaluable resource.

Glucose Intake And Utilization In Pre Diabetes And Diabetes

DOWNLOAD
Author : Ronald Ross Watson
language : en
Publisher: Elsevier
Release Date : 2014-11-22

Glucose Intake And Utilization In Pre Diabetes And Diabetes written by Ronald Ross Watson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-22 with Technology & Engineering categories.

This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular disease. Since pre-diabetes and diabetes are important cardiovascular disease risk factors, and impaired glucose metabolism among cardiac patients is extremely prevalent, the importance of reviewing pre-diabetes and its involvement in CVD complications is vital as one applies food and glycemic control to slow progress to diabetes and heart disease. The book further focuses on glucose intake and utilization in diabetes, including coverage of diabetes in the development and pathology of cardiovascular disease, risks and epidemiology of cardiovascular problems promoted by diabetes, macrovascular effects and their safety in therapy of diabetics, beta cell biology and therapy of diabetes, and nutrition to modulate diabetes. - Offers a complete review of cardiac health problems occurring with significant frequency in patients relative to their ability to regulate glucose - Presents coverage of the role of glucose utilization, development of pre-diabetes and the ultimate development of various cardiovascular diseases - Provides thorough dietary, nutrition, complementary and alternative botanical therapies for pre-diabetes and diabetes to halt the progression to cardiovascular disease

Understanding And Managing Diabetes Related Dermopathy

DOWNLOAD
Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2025-03-12

Understanding And Managing Diabetes Related Dermopathy written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-12 with Medical categories.

Explore the intricate interplay between diabetes and dermatology in 'Navigating the Nexus: Understanding and Managing Diabetes-Related Dermopathy'. This comprehensive treatise delves into the complexities of diabetes-related skin conditions, offering invaluable insights into their etiology, clinical manifestations, and diagnostic approaches. From the microvascular changes to the inflammatory pathways, each aspect is meticulously examined, providing a thorough understanding of the underlying mechanisms. Furthermore, discover evidence-based strategies for effective management, including novel therapies, wound care techniques, and holistic approaches to optimize patient outcomes. Whether you're a healthcare professional seeking to deepen your expertise or an individual navigating the challenges of diabetes-related skin issues, this treatise serves as an indispensable guide on the journey to skin health and overall well-being.

Stem Cell Engineering

DOWNLOAD
Author : Gerhard M. Artmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-29

Stem Cell Engineering written by Gerhard M. Artmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-29 with Technology & Engineering categories.

The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.

Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies

DOWNLOAD
Author : Mauro Perretti
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-04

Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies written by Mauro Perretti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-04 with categories.

In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this series of articles we foresee the birth of Resolution Pharmacology. The 16 contributions presented herein confirm the broad relevance of pro-resolving physio-pharmacology with the description of pro-resolving mechanisms in distinct diseases, from atherosclerosis and heart infarct, to cystic fibrosis and diabetes. This testifies on one hand the fundamental role that inflammatory mechanisms play in virtually all pathological settings and, on the other hand, the great potential that a novel approach to anti-inflammatory therapy by exploiting resolution mediators and targets may have. Thus, while there is broad recognition that evidence-based interventions have transformed cardiovascular, inflammation and endocrine care, new therapies are still needed for growing numbers of patients with unmet needs. As an example, an estimated 17 million people world-wide die annually of cardiovascular diseases, particularly heart attacks and strokes. Cardiovascular diseases occur almost equally in men and women and are the leading cause of death and morbidity worldwide. It is estimated that only 1/1,000 compounds entering preclinical testing are then trialled in man and the actual cost of developing a new therapeutic into clinical practice has grown exponentially over the past two decades (estimated $1.2B). Over the last 20 years or more, scientists have appreciated the biology of the resolution of inflammation, which provides a new paradigm in our understanding of the inflammatory process with the appreciation of genetic, molecular and cellular mechanisms that are engaged to actively resolve inflammation. The ‘resolution of acute inflammation’ is enabled by counter-regulatory checkpoints to terminate the host reaction while at the same time promoting healing and repair. The potential of lipid mediators to enact pro-resolving effects in the context of cystic fibrosis is presented by Recchiuti et al., while Fredman reasons on the potential for these molecules in atherosclerosis. This resonates well with the contributions from Bäck and colleagues who have focused on pro-resolving receptors to offer vasculo-protection in intimal hyperplasia and more generally in cardiovascular disease. On the same vein is the scholar contribution of Leoni and Soehnlein who focus on heart disease, with Qin et al. presenting the latest findings on the effect of an Annexin A1-derived peptide in myocardial infarction. Hansen et al. and de Gaetano et al. bring in the complexity of diabetes and associated morbidity with a focus on specialised pro-resolving lipid mediators but also introducing the potential of dietary approaches. As the western diet favours disease, an omega-3 rich diet can lead to higher availability of lipid mediators to afford tissue protection if not reverting its pathological status. Docosahexaenoic acid and its bioactive derivatives are endowed with potent anti-nociceptive properties following bone fracture, as shown by Zhang et al. The broad relevance of the pharmacological approach reaches the skin with Resolvin D1 protecting against UV irradiation (Saito et al.). Reduced skin inflammation is also achieved with an Annexin A1 peptide that impacts on the outcome of heterologous transplantation (Lacerda et al.). Indeed, modulating the phenotype of immune cells can provide long lasting beneficial outcomes, as attained with CDK inhibitors (Cartwright et al.) and PI3K inhibitors in experimental gout (Galvao et al.). Such an effect is also achieved with a third group of pro-resolving therapeutics, the melanocortin receptor agonists, with important modulation of macrophage reactivity (Patruno et al.) with Spana et al., providing new pharmacology following selective activation of the MC1 receptor. Finally, Hopkin et al. discuss the potential for targeting immune cell trafficking as a way to control immune mediated diseases, bringing in not only pro-resolving mediator agonists, but also approaches to reduce chemo/cytokine gradients or modulating S1P and 11-beta hydroxysteroid dehydrogenase. Finally, we wish to highlight that this wealth of science has also bought to the forefront specific pro-resolving receptors (including FPR2/ALX, GPR32, ChemR23 and MC1), all G protein coupled receptors that are therefore amenable to pharmacological exploitation for drug discovery programmes. We see that not only agonists to the receptors can be developed, some of them modelled on the natural ligands (e.g. resolvins, lipoxins, Annexin A1-derived peptides or melanocortin peptides), but also that the creativity of this pharmacology can be attained through biased ligands and positive allosteric modulators. Deep knowledge of pro-resolving receptor biology and their cell-specific signalling can accelerate the generation of novel anti-inflammatory depicted on the resolution of inflammation. In conclusion, with this eBook, we propose time is ready to exploit the concepts of resolution and use its targets and mediators for the identification of better drugs to establish ‘Resolution Pharmacology’. We predict Resolution Pharmacology will represent an important innovation in the way common diseases will be treated in the next decades of this millennium.

Application Of Adult Stem Cells In Regenerative Medicine

DOWNLOAD
Author : Farshid Sefat
language : en
Publisher: Academic Press
Release Date : 2025-06-03

Application Of Adult Stem Cells In Regenerative Medicine written by Farshid Sefat and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-03 with Science categories.

Application of Adult Stem Cells in Regenerative Medicine offers a comprehensive overview of tissue engineering using adult stem cells to treat various disorders throughout the human body. The book introduces readers to adult stem cells, tissue engineering, and their application in regenerative medicine. It covers many new and up-to-date techniques, providing a solid foundation for understanding the field. Written by global leaders, this resource is invaluable for anyone studying, researching, or working in the areas of adult stem cells, tissue engineering, or regenerative medicine.The book is divided into three parts. Part One provides an introduction to adult stem cells and their application in regenerative medicine. Part Two focuses on different body organ systems, including the nervous, respiratory, digestive, urinary, circulatory, endocrine, skeletal, reproductive, muscular, and ocular systems. Part Three concludes with a review of the future of adult stem cells in regenerative medicine. This structure ensures that readers gain a thorough understanding of the current state and future potential of adult stem cells in treating various disorders. - Provides extensive application of adult stems cells in tissue engineering and regenerative medicine - Presents various examples of adult stem cells for different organs within the human body - Discusses the latest innovations in adult stem cells

Yearbook Of Pediatric Endocrinology 2008

DOWNLOAD
Author : J. -C. Carel
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2008-08-22

Yearbook Of Pediatric Endocrinology 2008 written by J. -C. Carel and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-22 with Medical categories.

The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. The ‘Yearbook of Pediatric Endocrinology 2008’ brings you abstracts of articles that reported the year’s breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field. Twelve Associate Editors and their co-authors selected from several thousand papers those that brought the most meaningful new information, summarized them and provided comments to put them into perspective. The papers are classified into those that identify new genes involved in diseases, new hormones, concepts revised or re-centered, important observations for clinical practice, large-scale clinical trials, new mechanisms, new paradigms, important review articles, new fears and new hopes. This is the fifth volume of the ‘Yearbook of Pediatric Endocrinology’. To acknowledge the European Society for Paediatric Endocrinology (ESPE) endorsement of the Yearbook, the publication of the Yearbook is linked to ESPE’s annual meetings, covering the medical and scientific literature from March 2007 through May 2008. The ‘Yearbook of Pediatric Endocrinology 2008’ will help busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists keep informed on new advances in their field.

Type 2 Diabetes And Dementia

DOWNLOAD
Author : Velandai Srikanth
language : en
Publisher: Academic Press
Release Date : 2018-02-09

Type 2 Diabetes And Dementia written by Velandai Srikanth and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-09 with Medical categories.

Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. - Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics - Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology - Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications