Nuclear Chromosomal And Genomic Architecture In Biology And Medicine
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Nuclear Chromosomal And Genomic Architecture In Biology And Medicine
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Author : Malgorzata Kloc
language : en
Publisher: Springer Nature
Release Date : 2022-11-08
Nuclear Chromosomal And Genomic Architecture In Biology And Medicine written by Malgorzata Kloc and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-08 with Science categories.
This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.
Chromosome Biology As A Key To Understand Disease Mechanisms Genome Architecture And Evolution
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Author : Anja Weise
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-16
Chromosome Biology As A Key To Understand Disease Mechanisms Genome Architecture And Evolution written by Anja Weise and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-16 with Science categories.
This topic has been realized, and is in collaboration with Dr. Constanze Pentzold, Post Doctoral Researcher at the Institute of Human Genetics, University Hospital Jena.
Chromosome Architecture
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Author : Mark C. Leake
language : en
Publisher: Springer Nature
Release Date : 2022-05-30
Chromosome Architecture written by Mark C. Leake and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-30 with Science categories.
This detailed new edition collects cutting-edge laboratory protocols, techniques, and applications in use by some of the leading international experts in the broad field of chromosome architecture. The book emphasizes the increasing physiological relevance of chromosome architecture investigation, manifest both through application of more complex bottom-up assays in vitro as well as through maintaining the native physiological context through the investigation of living, functional cells. In addition, the chapters reflect the dramatic improvement in the length scale of precision by utilizing single-molecule approaches, both for imaging the DNA content of chromosome and proteins that bind to DNA as well as using methods that can controllably manipulate single DNA molecules, and the use of advanced computational methods and mathematical analysis is also featured. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromosome Architecture: Methods and Protocols, Second Edition is an ideal guide for researchers working in this dynamic area of study.
Human Interphase Chromosomes
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Author : Yuri B. Yurov
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-03
Human Interphase Chromosomes written by Yuri B. Yurov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-03 with Medical categories.
This title will focus on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and human genome function in interphase nuclei at the chromosomal level have been repeatedly shown to play a significant role in a variety of basic biological processes involved in realization and inheritance of genetic information within and between species. Current biomedical sciences of post-genomic era refocus basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, related processes are a target of studies elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation etc. Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in clinical, diagnostic and research practice to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This title will serve as a source of new valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.
Nuclear Structure Gene Expression
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Author : R. Curtis Bird
language : en
Publisher: Academic Pr
Release Date : 1997
Nuclear Structure Gene Expression written by R. Curtis Bird and has been published by Academic Pr this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
The Nuclear Matrix And Spatial Organization Of Chromosomal Dna Domains
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Author : Sergey V. Razin
language : en
Publisher:
Release Date : 1997-01-01
The Nuclear Matrix And Spatial Organization Of Chromosomal Dna Domains written by Sergey V. Razin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Chromosomes categories.
This is the first monograph giving an all-round description of different aspects of the eukaryotic genome functional architecture. It focuses on how the spatial organization of a genome within a eukaryotic cell nucleus fulfills the specific needs of the genome functioning. This volume presents an integral view of eukaryotic cell nuclei functional compartmentalization with special emphasis on the genome spatial organization and the functional significance of this organization.
Genomic And Personalized Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-10-30
Genomic And Personalized Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-30 with Science categories.
Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Genomic Medicine
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Author : Dhavendra Kumar
language : en
Publisher: Oxford Monographs on Medical G
Release Date : 2014-10-15
Genomic Medicine written by Dhavendra Kumar and has been published by Oxford Monographs on Medical G this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-15 with Medical categories.
Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Mitonuclear Ecology
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Author : Geoffrey E. Hill
language : en
Publisher: Oxford University Press, USA
Release Date : 2019-04-30
Mitonuclear Ecology written by Geoffrey E. Hill and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-30 with Science categories.
This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.