Nuclear Receptors Coregulators And Human Diseases

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Nuclear Receptors Coregulators And Human Diseases

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Author : Rakesh Kumar
language : en
Publisher: World Scientific
Release Date : 2008-03-14

Nuclear Receptors Coregulators And Human Diseases written by Rakesh Kumar and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-14 with Medical categories.

This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the “classic” papers as well as perspectives on future directions for the field.

Nr Coregulators And Human Diseases

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Author : Rakesh Kumar (Ph. D.)
language : en
Publisher: World Scientific
Release Date : 2008

Nr Coregulators And Human Diseases written by Rakesh Kumar (Ph. D.) and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.

This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the OC classicOCO papers as well as perspectives on future directions for the field. Sample Chapter(s). Chapter 1: Nuclear Receptor Coregulators in Human Diseases (839 KB). Contents: Nuclear Receptor Coregulators in Human Diseases (R B Lanz et al.); p160 Coactivators: Critical Mediators of Transcriptional Activation by Nuclear Receptors (J H Kim & M R Stallcup); Regulation of Nuclear Hormone Receptor Functions by Ubiquitin-Proteasome Pathway (A Ismail et al.); Coregulators as Oncogenes and Tumor Suppressors (R Kumar & A E Gururaj); A Central Role of SRC-3/AIB1 in Tumorigenesis (J Yan et al.); Thyroid Hormone Receptors, Coregulators, and Disease (M L Privalsky); Androgen Receptor Coactivators in Prostate Cancer (N L Weigel & I U Agoulnik); PGC-1 and Metabolic Control in Skeletal and Cardiac Muscle (Z Arany & B M Spiegelman); Coregulators in Metabolic and Neurodegenerative Diseases (J N Feige et al.); Role of the RIP140 Corepressor in Metabolic Regulation (M G Parker et al.); Nuclear Receptor Corepressors and Metabolism (T Alenghat & M A Lazar); Coregulators in CNS Function and Disease (O C Meijer & E R de Kloet); Tissue Repair and Cancer Control Through PPARs and Their Coregulators (L Michalik & W Wahli); Coregulators and Inflammation (S Ghisletti & W Huang); Nuclear Receptor Coactivators in the Cardiovascular System (J-M Xu); Coregulators as Determinants of Selective Receptor Modulator (SRM) Activity (M C Pace & C L Smith); Coregulators in Toxicology (J Regg et al.); Nuclear Receptor Coactivators Co-ordinate Metabolic Responses to Hormonal and Environmental Stimuli (R M Evans et al.); Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery (L L Grasfeder & D P McDonnell). Readership: Academic, medical students, residents, fellow and biomedical research students."

Nuclear Receptors In Human Health And Disease

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Author : Moray J. Campbell
language : en
Publisher: Springer Nature
Release Date : 2022-09-15

Nuclear Receptors In Human Health And Disease written by Moray J. Campbell and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-15 with Medical categories.

This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.

Genetic Steroid Disorders

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Author : David M. Lonard
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-08-22

Genetic Steroid Disorders written by David M. Lonard and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-22 with Medical categories.

Nuclear receptors are transcription factors that bind steroid, retinoid and thyroid hormones, and other ligands to drive hormone-dependent gene expression in conjunction with co-activators and co-repressors, collectively referred to as co-regulators. So far, more than 400 co-regulators have been reported in the literature and they have been implicated in a wide variety of pathological conditions, genetic syndromes, and in cancer. A key feature of co-regulator-based disease is the pleiotropic effects that disruption of normal co-regulator function has on energy metabolism, neurological function, and susceptibility to cancer. Technological advances in proteomics, genomics, and transcriptomics are leading to new ways to understand the pleiotropic actions of co-regulators. We expect that co-regulator ‘omics’ will lead to ways of understanding how co-regulators can be evaluated in the context of other complex genetic factors, hormones, diet, the environment, and stress. The broad role that co-regulators have in human pathological conditions makes it important to consider them as important new drug targets, such as for the treatment of hormone-dependent cancers or for indications related to energy metabolism. Better system-wide knowledge of co-regulator control of transcription and physiology is expected to lead to the best placement for future co-regulator-based therapies.

Nuclear Receptors And Coregulators In Metabolism And Immunity

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Author : Rongrong Fan
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-04

Nuclear Receptors And Coregulators In Metabolism And Immunity written by Rongrong Fan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-04 with Medical categories.

Nuclear Receptors From Structure To The Clinic

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Author : Iain J. McEwan
language : en
Publisher: Springer
Release Date : 2015-08-20

Nuclear Receptors From Structure To The Clinic written by Iain J. McEwan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-20 with Medical categories.

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors. ​

The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level

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Author : Mary Ann Asson-Batres
language : en
Publisher: Springer
Release Date : 2014-06-24

The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level written by Mary Ann Asson-Batres and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-24 with Medical categories.

A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.

Nuclear Hormone Receptors

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Author : Malcolm G. Parker
language : en
Publisher:
Release Date : 1991

Nuclear Hormone Receptors written by Malcolm G. Parker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Science categories.

An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.

Nr Coregulators And Human Diseases

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Author : Rakesh Kumar
language : en
Publisher: World Scientific
Release Date : 2008

Nr Coregulators And Human Diseases written by Rakesh Kumar and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.

This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the ?classic? papers as well as perspectives on future directions for the field.

The Nuclear Receptor Superfamily

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Author : Iain J. McEwan, PhD
language : en
Publisher: Humana Press
Release Date : 2008-12-12

The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-12 with Science categories.

Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.