The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level
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The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level
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Author : Mary Ann Asson-Batres
language : en
Publisher: Springer
Release Date : 2014-06-24
The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level written by Mary Ann Asson-Batres and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-24 with Medical categories.
A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
The Biochemistry Of Retinoid Signaling Iii
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Author : Mary Ann Asson-Batres
language : en
Publisher: Springer Nature
Release Date : 2020-04-15
The Biochemistry Of Retinoid Signaling Iii written by Mary Ann Asson-Batres and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-15 with Medical categories.
This book covers subjects that have major impacts on society, such as the mechanism of maternal-fetal transfer of vitamin A, and the effects of alcohol on retinoic acid signaling and mammalian embryonic development. There has been an awareness of the importance of consuming vitamins throughout human history, but empirical studies of their physiological role and mode of action only began about 150 years ago. Since then, the biochemical nature of vitamin A and its active derivative, retinoic acid, have been identified and researchers around the globe have investigated retinoic acid’s physiological function in growth processes and in maintaining life Written by leading experts, this book discusses the latest findings and advances in retinoic acid research. It addresses topics such as the role of retinoic acid signaling in a multitude of processes, including limb, heart and respiratory system development, as well as its role in maintaining postnatal organ systems. This book is a valuable resource for scientists involved in vitamin A/retinoic acid research and readers interested in developmental biology.
Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods
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Author : Nilsson, Charlotte
language : en
Publisher: Nordic Council of Ministers
Release Date : 2020-04-19
Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods written by Nilsson, Charlotte and has been published by Nordic Council of Ministers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-19 with Political Science categories.
Available online: https://pub.norden.org/temanord2020-507/ Abstract [en] This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap. The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.
International Review Of Cell And Molecular Biology
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-02-17
International Review Of Cell And Molecular Biology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-17 with Science categories.
International Review of Cell and Molecular Biology (IRCMB), Volume 330 includes comprehensive and detailed reviews on the current advances in cell and molecular biology. The IRCMB series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. IRCMB ranks high amongst scientific journals dealing with cell biology. - Includes comprehensive and detailed reviews on the current advances in cell and molecular biology - Publishes only invited review articles on selected topics - Authored by established and active cell and molecular biologists, drawn from international sources - Offers a wide range of perspectives on specific subjects
Gene Regulation Epigenetics And Hormone Signaling
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Author : Subhrangsu S. Mandal
language : en
Publisher: John Wiley & Sons
Release Date : 2017-05-09
Gene Regulation Epigenetics And Hormone Signaling written by Subhrangsu S. Mandal and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-09 with Science categories.
Das erste Referenzwerk dieser Art mit einer umfassenden und dennoch prägnanten Einführung in die Epigenetik beschäftigt sich mit den unzähligen Interaktionen zwischen Hormonregulation und Epigenetik. Die Inhalte sind gut strukturiert. Es gibt keine Überschneidungen zwischen den Kapiteln und jedes Kapitel beinhaltet Zusatzmaterialien für Präsentationen. Der Schwerpunkt liegt durchgängig auf Erkrankungen. Zielgruppe sind die vielen Physiologen und Entwicklungsbiologen, die zwar mit der Bedeutung und den Mechanismen der Hormonregulation vertraut sind, aber über unzureichendes Hintergrundwissen im Bereich Epigenetik verfügen.
Deep Homology
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Author : Lewis I. Held, Jr
language : en
Publisher: Cambridge University Press
Release Date : 2017-02-16
Deep Homology written by Lewis I. Held, Jr and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-16 with Business & Economics categories.
A comparison of the genetic circuits of Homo sapiens and Drosophila reveals the evidence for deep homology.
Stem Cells And Lineage Commitment
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Author : Kursad Turksen
language : en
Publisher: Springer Nature
Release Date : 2023-11-07
Stem Cells And Lineage Commitment written by Kursad Turksen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-07 with Science categories.
This detailed volume explores a variety of techniques used to study lineage commitment in stem cells. Further elucidation of the process that stem cells undergo on their way to becoming more specified cell types is vital for a more complete understanding of cell biology and overall physiology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cells and Lineage Commitment: Methods and Protocols serves as an ideal guide for experts and novices in the field of stem cell biology.
Burger S Medicinal Chemistry Drug Discovery And Development 8 Volume Set
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Author :
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-20
Burger S Medicinal Chemistry Drug Discovery And Development 8 Volume Set written by and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-20 with Science categories.
Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.
Retinoids As Anti Cancer Agents In Breast Cancer
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Author : Manzoor Ahmad Mir
language : en
Publisher: Academic Press
Release Date : 2025-07-01
Retinoids As Anti Cancer Agents In Breast Cancer written by Manzoor Ahmad Mir and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-01 with Science categories.
Retinoids as Anti-cancer Agents in Breast Cancer: A New Hope for Breast Cancer Treatment offers a comprehensive overview of the latest research and advancements in using retinoids to treat breast cancer. The book delves into novel approaches, including drug combinations and the development of new pharmaceuticals. It provides an in-depth analysis of current treatment methods, highlighting both challenges and opportunities in the field. Topics covered include the principles and mechanisms of retinoids as anti-cancer agents, preclinical and clinical studies, and advancements in drug delivery systems and nano-formulations.Future research directions are also explored, emphasizing new drug combinations, biomarkers for patient selection, and personalized treatment strategies. This book will serve as a platform for students, researchers, oncologists, pharmacologists, and healthcare professionals who want to understand the potential of retinoids in clinical practice. - Provides insights into the need for using cutting-else technology to develop novel pharmaceutical agents based on bioactive natural compounds for the efficient cancer treatment of breast cancer - Captures new research and knowledge to fully understand and potentially optimize the use of retinoids in breast cancer treatment - Evaluates the potential of retinoids in breast cancer treatment as novel alternatives to mainstream breast cancer therapy
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1994
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medicine categories.