Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods
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Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods
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Author : Nilsson, Charlotte
language : en
Publisher: Nordic Council of Ministers
Release Date : 2020-04-19
Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods written by Nilsson, Charlotte and has been published by Nordic Council of Ministers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-19 with Political Science categories.
Available online: https://pub.norden.org/temanord2020-507/ Abstract [en] This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap. The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.