Nuclear Receptors In Development
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Nuclear Receptors In Development
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-11-07
Nuclear Receptors In Development written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-07 with Science categories.
A superb compilation of reviews from leading experts in the field of nuclear receptors, volume 16 in the Advances in Developmental Biology series covers the role of different nuclear receptor subfamilies in development, physiology and metabolism. This volume brilliantly reviews how genetic defects in the function of nuclear receptors leads to various developmental defects. Receptors discussed include: thyroid receptors, peroxisome proliferators activated receptors, and retinoic acid receptors. Additionaly, this volume offers an indespesable chapter on the orphan receptors Ftz-F1, COUPs, and RORs in embryonic and postnatal development. * Provides a compilation of reviews of several nuclear receptor subfamilies - such as TRs, PPARs, RARs, the orphan receptors COUP-TFs, RORs, and Ftz-F1 in embryonic and postnatal development. * Offers a detailed section on retinoid receptor signaling * Covers the role of co-repressors and co-activators in modulation of nuclear receptor functions
Nuclear Receptors In Development And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-05-17
Nuclear Receptors In Development And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-17 with Science categories.
Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. New chapters in this release cover the Evolution of Nuclear Receptors and Ligand Signaling: Towards a Soft Key–Lock Model?, The Function and Evolution of Nuclear Receptors in Insect Embryonic Development, Nuclear Receptors in Skeletal Homeostasis, Estrogen Hormone Biology, and the Mechanisms of Glucocorticoid Action During Development. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. Covers the area of nuclear receptors in development and disease Includes contributions from an International board of authors Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments
The Nuclear Receptor Superfamily
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Author : Iain J. McEwan, PhD
language : en
Publisher: Humana Press
Release Date : 2010-11-19
The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-19 with Science categories.
Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.
Nuclear Receptors
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Author :
language : en
Publisher: Elsevier
Release Date : 2003-11-25
Nuclear Receptors written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-25 with Science categories.
Nuclear Receptors are inducible transcription factors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to DNA sequences. *Analysis of Nuclear Receptor Ligands*Structure/Function Analysis of Nuclear Receptors*Analysis of Nuclear Receptor Co-Factors and Chromatin Remodeling
Nuclear Receptors
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Author : Mostafa Z. Badr
language : en
Publisher: Springer Nature
Release Date : 2021-09-28
Nuclear Receptors written by Mostafa Z. Badr and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-28 with Medical categories.
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
Nuclear Receptors From Structure To The Clinic
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Author : Iain J. McEwan
language : en
Publisher: Springer
Release Date : 2015-08-20
Nuclear Receptors From Structure To The Clinic written by Iain J. McEwan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-20 with Medical categories.
Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
Nuclear Receptors In Human Health And Disease
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Author : Moray J. Campbell
language : en
Publisher: Springer Nature
Release Date : 2022-09-15
Nuclear Receptors In Human Health And Disease written by Moray J. Campbell and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-15 with Medical categories.
This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
Nuclear Receptors As Drug Targets
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Author : Eckhard Ottow
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Nuclear Receptors As Drug Targets written by Eckhard Ottow and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Medical categories.
Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
The In Vivo Function Of Nuclear Receptors During Drosophila Development
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Author : Aleksandar Sasha Necakov
language : en
Publisher:
Release Date : 2010
The In Vivo Function Of Nuclear Receptors During Drosophila Development written by Aleksandar Sasha Necakov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Nuclear Receptors In Drug Metabolism
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Author : Wen Xie
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-03
Nuclear Receptors In Drug Metabolism written by Wen Xie and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-03 with Science categories.
This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.