Nucleic Acid Chemistry
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Nucleic Acids In Chemistry And Biology
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Author : G Michael Blackburn
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-11-09
Nucleic Acids In Chemistry And Biology written by G Michael Blackburn and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-09 with Science categories.
The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.
Basic Principles In Nucleic Acid Chemistry V1
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Author : Paul O.P. Ts'o
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Basic Principles In Nucleic Acid Chemistry V1 written by Paul O.P. Ts'o and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Basic Principles in Nucleic Acid Chemistry, Volume I provides information pertinent to the fundamental aspects of nucleic acids. This book discusses the development of the basic principles in nucleic acid research that will serve as a foundation for further advancement in nucleic acid research. Organized into six chapters, this volume begins with an overview of the history of the scientific study of nucleic acid as a genetic material. This text then examines the utility of the analogs of the naturally occurring nucleic acid components as biochemical tools and as therapeutic agents. Other chapters consider mass spectrometry that deals with the production and chemistry of ions in the vapor phase. This book discusses as well the various aspects of the excited states of the nucleic acids. The final chapter deals with the systematic study of the physiochemical properties of the monomeric units of nucleic acid. This book is a valuable resource for molecular biologists, scientists, and research workers.
Organic Chemistry Of Nucleic Acids
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Author : N. Kochetkov
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Organic Chemistry Of Nucleic Acids written by N. Kochetkov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The study of nucleic acids is one of the most rapidly developing fields in modern science. The exceptionally important role of the nucleic acids as a key to the understanding of the nature of life is reflected in the enormous number of published works on the subject, including many outstanding monographs and surveys. The pathways of syn thesis and metabolism of nucleic acid,s and the many and varied biological functions of these biopolymers are examined with the utmost detail in the literature. Nearly as much attention has been paid to the macromolecular chemistry of the nucleic acids: elucidation of the size and shape of their molecules, the study of the physicochemical properties of their solutions, and the appropriate methods to be used in such research. The surveys of the chemistry of nucleic acids which have been published so far deal almost entirely with their synthesis and, in particular, with the synthetic chemistry of monomers (nucleosides and nucleotides) ; less attention has been paid to the synthesis of poly nucleotides. There is yet another highly important aspect of the chemistry of nucleic acids which is still in the formative stage, the study of the reactivity of nucleic acid macromolecules and their components. This can make an important contribution to the deter mination of the structure of these remarkable biopolymers and to the correct understanding of their biological functions.
Basic Principles In Nucleic Acid Chemistry V2
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Author : Paul O.P. Ts'o
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Basic Principles In Nucleic Acid Chemistry V2 written by Paul O.P. Ts'o and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Basic Principles in Nuclear Acid Chemistry, Volume II presents the significant progress in nucleic acid research and its contribution and influence on various aspects of human life. This book contains five chapters and begins with the susceptibility of nucleic acids towards attack by chemical reagents whose reactions with polynucleotides have been studied. This topic is followed by a presentation of experimental techniques used to study the properties of nucleic acids. The following chapter discusses some basic features embodied in the polyribo- and poly-deoxyribonucleotide backbone chains; the possibility of rotation around backbone bonds in the ""random"" single-stranded form; and the short- and long-range interactions in idealized and real chains. This chapter also looks into the thermodynamic and polyelectrolyte aspects of nucleic acid behavior. A chapter describes the special features of the third class of DNA, namely, closed duplex DNA, in which covalent chain scissions are absent. The last chapter examines the intrinsic properties and the interaction of the dimers and oligomers, with special emphasis on the influence of the phosphodiester linkages on the conformation and interaction of these short segments of nucleic acids. This book is of great value to workers in biomedical research and to higher level biochemistry instructors.
The Nucleic Acids
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Author : Erwin Chargaff
language : en
Publisher:
Release Date : 1955
The Nucleic Acids written by Erwin Chargaff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1955 with Nucleic acids categories.
Nucleic Acid Chemistry
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Author : Leroy B. Townsend
language : en
Publisher: Wiley-Interscience
Release Date : 1978
Nucleic Acid Chemistry written by Leroy B. Townsend and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Science categories.
This fourth part of a continuing series gives detailed information on up-to-date approaches that enable researchers to select suitable procedures. The descriptions provided are detailed so the novice, as well as those with experience, will be able to apply information in the laboratory.
The Nucleic Acids
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Author : Erwin Chargaff
language : en
Publisher:
Release Date : 1960
The Nucleic Acids written by Erwin Chargaff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1960 with Nucleic acids categories.
Supramolecular Nucleic Acid Chemistry
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Author : James Tucker
language : en
Publisher: Frontiers Media SA
Release Date : 2020-10-28
Supramolecular Nucleic Acid Chemistry written by James Tucker and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Medicinal Chemistry Of Nucleic Acids
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Author : Lihe Zhang
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-10
Medicinal Chemistry Of Nucleic Acids written by Lihe Zhang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-10 with Medical categories.
Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.
Current Protocols In Nucleic Acid Chemistry
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Author : Serge L. Beaucage
language : en
Publisher: Current Protocols
Release Date : 2000
Current Protocols In Nucleic Acid Chemistry written by Serge L. Beaucage and has been published by Current Protocols this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Science categories.
Good methods must be reliable, well-tested, and honed to minimize the time and expense required to achieve the desired results. CPNC provides a continuously growing and evolving set of protocols that allows researchers to benefit from the experience of other researchers around the world. The core manual provides a comprehensive set of protocols that have been compiled, revised, and streamlined over the last 6 years. Quarterly updates provide new protocols in emerging areas of research as well as continued advances and new applications for fundamental methods. The book is designed to grow and change with the field of nucleic acid chemistry. Fundamental nucleoside chemistry methods include sugar-base condensation, phosphorylation, and nucleoside protection. Methods for oligonucleotide synthesis include H-phosphonate and phosphoramidite approaches, solid-phase and solution-phase synthesis, large-scale synthesis, synthesis for modified and unmodified oligonucleotides, conjugation of oligonucleotides, synthesis without base protection, and synthesis on microarrays. More specialized synthetic methods include synthesis of biologically active nucleosides and prodrugs. Purification and characterization methods are detailed. Advanced methods include biophysical analysis, combinatorial methods, and nanotechnology. Each protocol includes rationale for choosing appropriate methods, step-by-step procedures, complete recipes, anticipated results, characterization data, and troubleshooting, as well as background and recommended reading. The level of procedural detail is far beyond that found in the research literature, and tips and comments from authors are geared towards ensuring reliable duplication in the laboratory.
