Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders
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Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders
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Author : Aasef G. Shaikh
language : en
Publisher: Frontiers Media SA
Release Date : 2018-08-29
Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders written by Aasef G. Shaikh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-29 with categories.
Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.
Eye Movement Disorders
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Author : E.A.C.M. Sanders
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Eye Movement Disorders written by E.A.C.M. Sanders and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
There is perhaps no area of neuro-ophthalmology that is advancing more rapidly with respect to an understanding of its anatomy and physiology than the ocular motor system. For this reason, it is difficult not only to keep up with the latest information concerning the basic mechanisms involved in the control of eye movements but also to remain up to date regarding the pathophysiology of specific disorders of eye movement. The material in this book is derived from a two-day course on eye movements held in The Netherlands in 1986. The course was designed as an introduction to the normal ocular motor system and to disorders of eye movements and was aimed toward orthoptists, ophthalmolo gists, optometrists, neurologists, and neurosurgeons. The chapters in this book were compiled by a trio of experts in the field of eye movements and contain discussions of anatomy and physiology of the ocular motor system, techniques of examination of patients with diplopia, and pathophysiology of specific disorders of ocular motility. Many of the authors of these chapters are among the most active investigators of eye movements in the world today, and their comments thus reflect the latest information in the field. This text is both basic and com prehensive and thus has something for everyone, from the student just beginning a study of the ocular motor system to the seasoned 'veteran' who wishes to know the latest information regarding central ocular motor control mechanisms. Neil R.
Pediatric Neuro Ophthalmology
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Author : Michael C. Brodsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pediatric Neuro Ophthalmology written by Michael C. Brodsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Pediatric Neuroophthalmology details the diagnostic criteria, current concepts of pathogenesis, neuroradiological correlates, and clinical management of a large group of neuroophthalmic disorders that present in childhood. Surprisingly distinct from neuroophthalmic disorders afflicting adults, this set of diseases falls between the cracks of most ophthalmology training, and thus, warrants a practical, clinical guide for the practitioner in ophthalmology - the neuroophthalmologist, pediatric ophthalmologist, general ophthalmologist - as well as neurologists and for residents. The authors, leading pediatric ophthalmologists, have taken this difficult subject matter and developed an accessible, user-friendly manual with a detailed approach to the recognition, differential diagnosis, and management of pediatric neuroophthalmologic disorders.
Advances In Translational Neuroscience Of Eye Movement Disorders
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Author : Aasef Shaikh
language : en
Publisher: Springer Nature
Release Date : 2020-01-03
Advances In Translational Neuroscience Of Eye Movement Disorders written by Aasef Shaikh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-03 with Medical categories.
A comprehensive book that reviews advances in ocular motor research on topics of general interest, rare, specialized or unique conditions, and pertinent basic neuroscience. A rare collection with contributions from basic neuroscientists, neurologists, and ophthalmologists. Includes dedicated chapters on mathematical models, pharmacotherapy, neuromodulation, motion perception, visual influence on eye movement, physiology of strabismus, and microsaccades. This book is dedicated to David Robinson - one of the pioneers of contemporary ocular motor and vestibular neuroscience.
Neuroanatomy Text And Atlas Fifth Edition
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Author : John D. Martin
language : en
Publisher: McGraw Hill Professional
Release Date : 2019-12-22
Neuroanatomy Text And Atlas Fifth Edition written by John D. Martin and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-22 with Medical categories.
A regional and functional approach to learning human neuroanatomy – enhanced by additional full-color illustrations and PowerPoint® slides of all images in the text for instructors! Neuroanatomy: Text and Atlas covers neuroanatomy from both a functional and regional perspective to provide an understanding of how the components of the central nervous system work together to sense the world around us, regulate body systems, and produce behavior. This trusted text thoroughly covers the sensory, motor, and integrative skills of the brains and presents an overview of the function in relation to structure and the locations of the major pathways and neuronal integrative regions. Neuroanatomy: Text and Atlas also teaches readers how to interpret the new wealth of human brain images by developing an understanding of the anatomical localization of brain function. The authoritative core content of myelin-stained histological sections is enhanced by informative line illustrations, angiography, and brain views produced by MRI, and other imaging technologies. • Revised and updated to reflect advances in clinical neuroanatomy and neural science • Full-color illustrations enrich the text, including many new to this edition • Chapters begin with a clinical case to illustrate the connections and functions of the key material • Chapters end with a series of multiple-choice review questions • NEW Online learning center will display brain views produced by MRI and PET • Increases knowledge of the regional and functional organization of the spinal cord and brain, one system at a time • Provides thorough coverage of the sensory, motor, and integrative systems of the brain, together with cerebral vasculature • Promotes understanding of the complex details of neuroanatomy needed for accurate interpretation of radiological image • Comprehensive atlas provides key views of the surface anatomy of the central nervous systems and photographs of myelin-stained sections in three anatomical planes • Includes learning aids such as clinical topics, boxes, chapter summaries, and a Glossary of key terms and structures
The Eye In Pediatric Systemic Disease
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Author : Alex V. Levin
language : en
Publisher: Springer
Release Date : 2017-06-20
The Eye In Pediatric Systemic Disease written by Alex V. Levin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Medical categories.
This book is the first of its kind to describe ocular manifestations of systemic diseases in the pediatric population. Written and edited by experts in areas of pediatric ophthalmology and genetics, this new text covers a multitude of topics in a comprehensive and cataloged fashion. The Eye in Pediatric Systemic Disease is designed as an in-depth and up-to-date reference work that is heavily referenced, thus allowing the reader ready access to the international supporting literature. Everything from ocular manifestations of hematologic disease, child abuse, psychiatric diseases, renal disorders, and vitamin disorders are covered, allowing readers to know what to look for in the eyes of children with a given systemic disorder. The Eye in Pediatric Systemic Disease is written in language that is accessible to ophthalmologists and pediatricians, as well as allied health care professionals.
Inherited Ataxias
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Author : A. E. Harding
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1993
Inherited Ataxias written by A. E. Harding and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
In this volume, more than 50 leading international experts review the latest scientific and clinical observations on inherited ataxias. The book demonstrates how molecular genetic studies, as well as recent physiological, neurochemical, and clinical data, have generated new concepts on the nosology of these disorders. Close attention is given to the important practical applications of these new findings - in diagnosis, prognosis, and genetic counseling, in development of tests for prenatal diagnosis and carrier detection, and in the search for more effective therapies. The opening chapter identifies the clinical features that distinguish the various inherited ataxic syndromes and presents a classification based on etiology, mode of inheritance, age of onset, and associated clinical features. A major portion of the book focuses on current clinical and molecular genetic studies of different forms of inherited ataxia. Coverage includes a molecular analysis of the Friedreich's ataxia locus and extensive studies on autosomal recessive spastic ataxia of Charlevoix-Saguenay, ataxia telangiectasia, dominantly inherited spinocerebellar ataxias, Machado-Joseph disease, and inherited prion diseases. The contributors provide detailed information on the various clinical phenotypes of each form of inherited ataxia and thoroughly explain the use of linkage analysis and other molecular genetic techniques to localize and isolate the genes responsible for these diseases. The book also reviews the most significant research findings on neurotransmitters in the cerebellum, on the phosphoinositide second messenger system in cerebellar degenerative disorders, and on oligodendrocyte-associated andmyelin-associated inhibitors of neurite growth in the adult nervous system. The contributors assess recent progress in developing drugs for treatment of ataxias and other cerebellar movement disorders and identify new targets for pharmacological intervention. Experimental therapeutic observations on cerebellar grafting in heredodegenerative ataxia are also presented. This volume is an invaluable reference for clinicians treating patients with ataxias or counseling families at risk for inherited neurological diseases. It is also a rich source of ideas for molecular geneticists and for neuroscientists investigating disorders of the cerebellum.
Uncommon Causes Of Movement Disorders
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Author : Néstor Gálvez-Jiménez
language : en
Publisher: Cambridge University Press
Release Date : 2011-05-12
Uncommon Causes Of Movement Disorders written by Néstor Gálvez-Jiménez and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-12 with Medical categories.
A large number of neurological conditions result in abnormal movements of the body; these are often characterized by changes in coordination and altered speed of voluntary movement. Many obscure diseases, conditions and environmental insults can cause movement disorders but these are often overlooked. This volume expands and differentiates the many varied clinical presentations of movement disorders. Written by an international team of authors, including some of the most prominent clinicians in the field, disorders are defined and expanded in a clinically useful manner. Pathophysiological theories, genetic discoveries, new classifications, differential diagnoses and therapies are discussed extensively. Uncommon Causes of Movement Disorders provides a broad and comprehensive review of the field, concentrating on conditions infrequently seen but essential for practitioners to recognize in order to implement appropriate management. This is a key text for movement disorders specialists and general neurologists at all stages of their career.
The Neurology Of Eye Movements Text And Cd Rom
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Author : Departments of Neurology R. John Leigh Professor, Neuroscience Otolaryngology and Biomedical Engineering Case Western Reserve University University Hospitals and Veterans Affairs Medical Center Cleveland Ohio
language : en
Publisher: Oxford University Press, USA
Release Date : 1999-08-26
The Neurology Of Eye Movements Text And Cd Rom written by Departments of Neurology R. John Leigh Professor, Neuroscience Otolaryngology and Biomedical Engineering Case Western Reserve University University Hospitals and Veterans Affairs Medical Center Cleveland Ohio and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-26 with Medical categories.
The Neurology of Eye Movements provides clinicians with a synthesis of current scientific information that can be applied to the diagnosis and treatment of disorders of ocular motility. Basic scientists will also benefit from descriptions of how data from anatomical, electrophysiological, pharmacological, and imaging studies can be directly applied to the study of disease. By critically reviewing such basic studies, the authors build a conceptual framework that can be applied to the interpretation of abnormal ocular motor behavior at the bedside. These syntheses are summarized in displays, new figures, schematics and tables. Early chapters discuss the visual need and neural basis for each functional class of eye movements. Two large chapters deal with the evaluation of double vision and systematically evaluate how many disorders of the central nervous system affect eye movements. This edition has been extensively rewritten, and contains many new figures and an up-to-date section on the treatment of abnormal eye movements such as nystagmus. A major innovation has been the development of an option to read the book from a compact disc, make use of hypertext links (which bridge basic science to clinical issues), and view the major disorders of eye movements in over 60 video clips. This volume will provide pertinent, up-to-date information to neurologists, neuroscientists, ophthalmologists, visual scientists, otalaryngologists, optometrists, biomedical engineers, and psychologists.
Traumatic Brain And Spinal Cord Injury
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Author : Cristina Morganti-Kossmann
language : en
Publisher: Cambridge University Press
Release Date : 2012-07-19
Traumatic Brain And Spinal Cord Injury written by Cristina Morganti-Kossmann and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-19 with Medical categories.
Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: • The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion • Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury • Overview of major pathophysiological changes • The development of animal models; successes and limitations • Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.