Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 489 In Vivo Mammalian Alkaline Comet Assay
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Test No 489 In Vivo Mammalian Alkaline Comet Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2014-09-26
Test No 489 In Vivo Mammalian Alkaline Comet Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-26 with categories.
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 489 In Vivo Mammalian Alkaline Comet Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2016-07-29
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 489 In Vivo Mammalian Alkaline Comet Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with categories.
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
A Practical Guide To Toxicology And Human Health Risk Assessment
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Author : Laura Robinson
language : en
Publisher: John Wiley & Sons
Release Date : 2018-11-05
A Practical Guide To Toxicology And Human Health Risk Assessment written by Laura Robinson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-05 with Science categories.
Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author’s training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.
Biomarkers In Toxicology
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Author : Ramesh C. Gupta
language : en
Publisher: Academic Press
Release Date : 2019-02-13
Biomarkers In Toxicology written by Ramesh C. Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-13 with Medical categories.
Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig A Gene Mutation Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2022-06-30
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig A Gene Mutation Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-30 with categories.
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 482 Genetic Toxicology Dna Damage And Repair Unscheduled Dna Synthesis In Mammalian Cells In Vitro
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 1986-10-23
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 482 Genetic Toxicology Dna Damage And Repair Unscheduled Dna Synthesis In Mammalian Cells In Vitro written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-10-23 with categories.
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
Drug Safety Evaluation
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Author : Shayne Cox Gad
language : en
Publisher: John Wiley & Sons
Release Date : 2023-01-12
Drug Safety Evaluation written by Shayne Cox Gad and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-12 with Medical categories.
Drug Safety Evluation Comprehensive and practical guide presenting a roadmap for safety assessment as an integral part of the development of drugs and therapeutics This fourth edition of Drug Safety Evaluation maintains the central objective of presenting an all-inclusive practical guide for those who are responsible for ensuring the safety of drugs and biologics to patients, healthcare providers, those involved in the manufacture of medicinal products, and all those who need to understand how the safety of these products is evaluated and shepherding valuable candidates to market. Individual chapters address specific approaches to evaluation hazards, including problems that are encountered and their solutions. Also covered are the scientific and philosophical bases for evaluation of specific concerns (e.g., carcinogenicity, development toxicity, etc.) to provide both understanding and guidance for approaching the new problems that have come to face both our society and the new challenges they brought. The many changes in regulatory requirements, pharmaceutical development, technology, and the effects of Covid on our society and science have required both extensive revision to every chapter and the addition of four new chapters. Specific sample topics covered in Drug Safety Evaluation include: The drug development process and the global pharmaceutical marketplace and regulation of human pharmaceutical safety Sources of information for consideration in study and program design and in safety evaluation Electronic records, reporting and submission, screens in safety and hazard assessment, and formulations, routes, and dosage regimens Mechanisms and endpoints of drug toxicity, pilot toxicity testing in drug safety evaluation, and repeat dose toxicity Genotoxicity, QSAR tools for drug safety, toxicogenomics, nonrodent animal studies, and developmental and reproductive toxicity testing An appendix which provides an up to date guide to CROs for conducting studies Drug Safety Evaluation was written specifically for the pharmaceutical and biotechnology industries, including scientists, consultants, and academics, to show a utilitarian yet scientifically valid path to the everyday challenges of safety evaluation and the problem solving that is required in drug discovery and development.
Big Data In Predictive Toxicology
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Author : Daniel Neagu
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-12-04
Big Data In Predictive Toxicology written by Daniel Neagu and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with Medical categories.
The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses these challenges as well as the opportunities of new techniques encountered in data science. It addresses the nature of toxicological big data, their storage, analysis and interpretation. It also details how these data can be applied in toxicity prediction, modelling and risk assessment. This title is of particular relevance to researchers and postgraduates working and studying in the fields of computational methods, applied and physical chemistry, cheminformatics, biological sciences, predictive toxicology and safety and hazard assessment.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 486 Unscheduled Dna Synthesis Uds Test With Mammalian Liver Cells In Vivo
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 1997-07-21
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 486 Unscheduled Dna Synthesis Uds Test With Mammalian Liver Cells In Vivo written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-07-21 with categories.
The purpose of the unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo is to identify substances that induce DNA repair after excision and removal of a stretch of DNA containing a region of damage induced by chemical substances ...
Oecd Series On Testing And Assessment Overview On Genetic Toxicology Tgs
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2017-04-13
Oecd Series On Testing And Assessment Overview On Genetic Toxicology Tgs written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-13 with categories.
Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that ...