Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 494 Vitrigel Eye Irritancy Test Method For Identifying Chemicals Not Requiring Classification And Labelling For Eye Irritation Or Serious Eye Damage
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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 494 Vitrigel Eye Irritancy Test Method For Identifying Chemicals Not Requiring Classification And Labelling For Eye Irritation Or Serious Eye Damage
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-17
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 494 Vitrigel Eye Irritancy Test Method For Identifying Chemicals Not Requiring Classification And Labelling For Eye Irritation Or Serious Eye Damage written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
The Vitrigel-Eye Irritancy Test (EIT) method is an in vitro test method that allows the identification of test chemicals not requiring classification and labelling for eye irritation or serious eye damage. This test measures the eye irritation potential of a test chemical based on its ability to induce damage to the barrier function of the human corneal epithelium (hCE) models used in the Vitrigel-EIT method. It is known that chemicals that are irritating to the eye first destroy tear film and epithelial barrier function of the eye, subsequently induce epithelial cell death, and finally produce stromal degeneration and endothelial cell death, resulting in corneal opacity. Therefore, the change of the epithelial barrier function is a relevant endpoint for detecting eye irritation. In the Vitrigel Eye Irritancy test method , time-dependent changes in the Transepithelial Electrical Resistance (TEER) values are indicative of damage to the barrier function of the corneal epithelium following exposure to a test chemical; this situation is similar to the observed damage of the rabbit cornea following exposure to a test chemical, which is an important mode of action leading to damage of the corneal epithelium and eye irritation. The Vitrigel-Eye Irritancy Test (EIT) method can be used within the limited applicability domain of test chemicals having pH > 5.0 (based on 2.5% weight/volume (w/v) preparation).
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 492b Reconstructed Human Cornea Like Epithelium Rhce Test Method For Eye Hazard Identification
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2024-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 492b Reconstructed Human Cornea Like Epithelium Rhce Test Method For Eye Hazard Identification written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-25 with categories.
This Test Guideline describes an in vitro procedure the identification on its own of chemicals (substances and mixtures) not requiring classification (No Cat), requiring classification for eye irritation (Cat 2) and requiring classification for serious eye damage (Cat 1) according to the UN GHS ocular hazard categories. It makes use of reconstructed human cornea-like epithelium (RhCE) which closely mimics the histological, morphological, biochemical and physiological properties of the human corneal epithelium.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 467 Defined Approaches For Serious Eye Damage And Eye Irritation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2025-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 467 Defined Approaches For Serious Eye Damage And Eye Irritation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
This Test Guideline proposes defined approaches (DA) combining data generated in vitro methods, with information sources such as physicochemical properties.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 405 Acute Eye Irritation Corrosion
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2023-07-04
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 405 Acute Eye Irritation Corrosion written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-04 with categories.
This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
Handbook Of Cosmetic Science And Technology
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Author : Frank Dreher
language : en
Publisher: CRC Press
Release Date : 2022-08-11
Handbook Of Cosmetic Science And Technology written by Frank Dreher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-11 with Medical categories.
With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice
Organotypic Models In Drug Development
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Author : Monika Schäfer-Korting
language : en
Publisher: Springer Nature
Release Date : 2021-03-25
Organotypic Models In Drug Development written by Monika Schäfer-Korting and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-25 with Medical categories.
This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
Biomedical Product And Materials Evaluation
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Author : P.V. Mohanan
language : en
Publisher: Woodhead Publishing
Release Date : 2022-01-22
Biomedical Product And Materials Evaluation written by P.V. Mohanan and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-22 with Technology & Engineering categories.
Biomedical Product and Materials Evaluation: Standards and Ethics provides a much-needed overview of the procedures, issues, standards and ethical issues in the early development of biomedical products. The book covers a range of key biomedical products, from 3D printed organs and blood derived products, to stem calls and decellularized tissue products. Each chapter reviews a single product type, associated materials, biomedical applications, proven development strategies, and potential challenges. The core focus of the book is on the standardization and ethical aspects of biomedical product development, with these elements addressed and discussed in chapters dedicated to product evaluation. This is a useful reference for academics, researchers and industry professionals in R&D groups with an interest in biomaterial research and production, as well as those working in the fields of biomedical engineering, biotechnology and toxicology. - Covers a variety of biomedical products, including specific biomaterials, organs-on-chips, wound care products, combinational products, and more - Delves into strategies and considerations for product evaluation, including cytotoxicity assays, microbial and blood compatibility studies - Discusses standardization and ethical hurdles in biomedical product development and how to overcome them
From Current To Future Trends In Pharmaceutical Technology
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Author : Natassa Pippa
language : en
Publisher: Elsevier
Release Date : 2023-11-30
From Current To Future Trends In Pharmaceutical Technology written by Natassa Pippa and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-30 with Medical categories.
From Current to Future Trends in Pharmaceutical Technology explores the current trends of this field and creates a multi-aspect framework for the reader. The book covers topics on pharmaceutics, pharmaceutical engineering, pre-formulation protocols, techniques, innovative excipients, bio-printing techniques, scale-up based on formulas on-a-chip, and regulatory aspects based on new scientific achievements. Modified dosage forms, new aspects on the compatibility of drug excipients interactions, and drug release by various dosage forms are included. Physical pharmacy (physical and biological stability of dosage forms), innovative excipients, patents on innovative formulations and regulatory issues related to the approval process of medicines are also discussed. The book is a valuable resource for a wide audience of academics, industrial researchers and professionals working in this field as the development of efficient and safe medicines is critical to future needs. - Includes innovative excipients/advanced materials in pharmaceutics - Covers modified release delivery platforms - Explores new elements of drug development
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 467 Approches D Finies Pour Les L Sions Oculaires Graves Et L Irritation Oculaire
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2025-06-25
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 467 Approches D Finies Pour Les L Sions Oculaires Graves Et L Irritation Oculaire written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
Cette Ligne directrice propose des approches définies (AD) combinant les données générées par des méthodes in vitro, avec des sources d’information telles que les propriétés physico-chimiques.
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 405 Effet Irritant Corrosif Aigu Sur Les Yeux
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2023-07-04
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 405 Effet Irritant Corrosif Aigu Sur Les Yeux written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-04 with categories.
Cette méthode fournit des informations sur les dangers pour la santé qui peuvent résulter de l’application d’une substance d’essai (solide ou liquide et d’aérosols) sur les yeux. Cette Ligne directrice est utilisée préférablement avec des lapins ...