Oecd Series On Testing And Assessment Report On Considerations From Case Studies On Integrated Approaches For Testing And Assessment Iata First Review Cycle 2015 Case Studies On Grouping Methods As A Part Of Iata
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Oecd Series On Testing And Assessment Report On Considerations From Case Studies On Integrated Approaches For Testing And Assessment Iata First Review Cycle 2015 Case Studies On Grouping Methods As A Part Of Iata
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2017-04-13
Oecd Series On Testing And Assessment Report On Considerations From Case Studies On Integrated Approaches For Testing And Assessment Iata First Review Cycle 2015 Case Studies On Grouping Methods As A Part Of Iata written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-13 with categories.
OECD member countries have been making efforts to expand the use of alternative methods in assessing chemicals. The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of ...
Oecd Series On Testing And Assessment Guidance Document For The Use Of Adverse Outcome Pathways In Developing Integrated Approaches To Testing And Assessment Iata
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2017-03-10
Oecd Series On Testing And Assessment Guidance Document For The Use Of Adverse Outcome Pathways In Developing Integrated Approaches To Testing And Assessment Iata written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with categories.
The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). However, there is a need for a systematic framework to characterise the individual biological and toxicological relevance of alternative methods in assessing chemicals in predicting toxicological endpoints.
The History Of Alternative Test Methods In Toxicology
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-20
The History Of Alternative Test Methods In Toxicology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-20 with Medical categories.
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Handbook Of Laboratory Animal Science
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Author : Jann Hau
language : en
Publisher: CRC Press
Release Date : 2021-05-17
Handbook Of Laboratory Animal Science written by Jann Hau and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-17 with Medical categories.
Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 429 Skin Sensitisation Local Lymph Node Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2010-07-23
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 429 Skin Sensitisation Local Lymph Node Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-23 with categories.
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 406 Skin Sensitisation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 1992-07-17
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 406 Skin Sensitisation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-07-17 with categories.
This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...
Oecd Series On Testing And Assessment Guidance Document On The Reporting Of Defined Approaches And Individual Information Sources To Be Used Within Integrated Approaches To Testing And Assessment Iata For Skin Sensitisation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2017-07-11
Oecd Series On Testing And Assessment Guidance Document On The Reporting Of Defined Approaches And Individual Information Sources To Be Used Within Integrated Approaches To Testing And Assessment Iata For Skin Sensitisation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-11 with categories.
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides guidance on the reporting of defined approaches to testing and assessment in the area of skin ...
Oecd Series On Testing And Assessment Guidance Document On An Integrated Approach On Testing And Assessment Iata For Skin Corrosion And Irritation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2017-04-13
Oecd Series On Testing And Assessment Guidance Document On An Integrated Approach On Testing And Assessment Iata For Skin Corrosion And Irritation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-13 with categories.
This Guidance Document proposes an integrated approach on testing and assessment (IATA) for skin corrosion and irritation. It also provides consistent information on key characteristics of each of the individual information sources of the IATA, and relevant guidance on how to integrate ...
Oecd Series On Testing And Assessment Second Edition Guidance Document On Integrated Approaches To Testing And Assessment Iata For Serious Eye Damage And Eye Irritation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-07-25
Oecd Series On Testing And Assessment Second Edition Guidance Document On Integrated Approaches To Testing And Assessment Iata For Serious Eye Damage And Eye Irritation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-25 with categories.
This document suggests an Integrated Approach on Testing and Assessment (IATA) for serious eye damage and eye irritation hazard identification. The document also provides key information characteristics of each of the individual information sources comprising the IATA. Furthermore it provides guidance on how and when to integrate existing and/or newly generated information for decision making, including decisions on the need for further testing or final decisions on classification and labelling regarding the potential eye hazard effects of test chemicals.
Oecd Series On Testing And Assessment Guidance Document On The Reporting Of Defined Approaches To Be Used Within Integrated Approaches To Testing And Assessment
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2017-04-13
Oecd Series On Testing And Assessment Guidance Document On The Reporting Of Defined Approaches To Be Used Within Integrated Approaches To Testing And Assessment written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-13 with categories.
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to testing and assessment that can be used as one of ...