Off Target
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Off Target The Captivating Disturbing New Thriller From The Author Of The Waiting Rooms
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Author : Eve Smith
language : en
Publisher: Orenda Books
Release Date : 2021-12-17
Off Target The Captivating Disturbing New Thriller From The Author Of The Waiting Rooms written by Eve Smith and has been published by Orenda Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-17 with Fiction categories.
When a one-night stand leads to a long-desired pregnancy, Susan will do anything to ensure her husband won't find out ... including the unthinkable. But when something horrendous is unleashed around the globe, her secret isn't the only thing that is no longer safe... 'An astute, well-researched and convincing novel of ideas' The Times 'If you could create a "perfect" baby through genetic engineering, would you? A disturbing and interesting thriller, perfect for book club discussions' Nina Pottell, Prima 'Provocative, pacy and scarily all-too-possible' Philippa East ––––––––––––An unthinkable decision A deadly mistake In an all-too-possible near future, when genetic engineering has become the norm for humans, not just crops, parents are prepared to take incalculable risks to ensure that their babies are perfect ... altering genes that may cause illness, and more... Susan has been trying for a baby for years, and when an impulsive one-night stand her dream come true, she'll do anything to keep her daughter and ensure her husband doesn't find out ... including the unthinkable. She believes her secret is safe. For now. But as governments embark on a perilous genetic arms race and children around the globe start experiencing a host of distressing symptoms – even taking their own lives – something truly horrendous is unleashed. Because those children have only one thing in common, and people are starting to ask questions... Bestselling author of The Waiting Rooms, Eve Smith returns with an authentic, startlingly thought-provoking, disturbing blockbuster of a thriller that provides a chilling glimpse of a future that's just one modification away... _____________ 'An effective thriller that will keep you hooked to the very end ... more than that, it's a nuanced, believable examination of how human genetic engineering might play out...' SFX Magazine 'A brilliantly chilling work of speculative fiction – a disturbing but all-too-possible vision of the near future, where each of us gets to play God. Superb!' Guy Morpuss 'Sharp, intelligent, frightening and original' NB Magazine 'An eerily prophetic near-future viewed through a compassionately anchoring lens ... As tempting and tantalising a read as the vision of the future it presents' SciFi Now 'This is what speculative fiction should be – plausible, pacy, and with a story that packs real emotional punch' Louise Mumford 'When a writer's work is compared to Michael Crichton's, there's reason to sit up and pay attention ... a cautionary tale that's full of thrills' LoveReading 'Eve Smith has done it again! A brilliant read' J.M. Hewitt 'One of the most exciting writers around ... master of the high-concept thriller' Chris McDonald Praise for The Waiting Rooms***** 'Combines the excitement of a medical thriller à la Michael Crichton with sensitive characterisation and social insight in a timely debut novel all the more remarkable for being conceived and written before the current pandemic' Guardian 'STUNNING and terrifying ... The Waiting Rooms wrenches your heart in every way possible' Miranda Dickinson 'Chillingly close to reality, this gripping thriller brims with authenticity ... a captivating, accomplished and timely debut from an author to watch' Adam Hamdy 'Engrossing and eye-opening, with heart-stopping plot twists ... a stunning medical thriller set in a terrifying possible future' Foreword Reviews For fans of Emily St John Mandel, Robin Cook, Tess Gerritsen and Louise Doughty
Off Target
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Author : Jim Thorn
language : en
Publisher:
Release Date : 2011
Off Target written by Jim Thorn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Off Target
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Author : Jill Ammon Vanderwood
language : en
Publisher: Human Rights Watch
Release Date : 2019-01-28
Off Target written by Jill Ammon Vanderwood and has been published by Human Rights Watch this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with Juvenile Nonfiction categories.
What would you do if your friend showed you a gun?You are new in town and it's your first day at a new school. Your neighbor, Trevor introduces you to a group of three boys and two girls. Right away you notice that Eric, one of the guys in the group, is being bullied at school. When you go to Eric's house with your new friends, he shows the group a fully loaded handgun that is left in his mother's nightstand. You are faced with some hard choices when someone suggests that Eric should take the gun to school.___________________________________________What should you do? It's time to choose a path: If you're worried that Eric will take the gun to school-continue on page 7.If you decide to take the gun to prevent anyone from being hurt-continue on page 9.If you leave the house with the others and plan to come back for target practice the next day-continue on page 10.____________________________________________Off Target is the first book in The Path You Choose series. You, the reader determine the outcome by the choices you make. Once you read one story, go back and choose a different story. There are thirteen possible endings in this book.What path will you choose
The Waiting Rooms
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Author : Eve Smith
language : en
Publisher: Orenda Books
Release Date : 2020-04-09
The Waiting Rooms written by Eve Smith and has been published by Orenda Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-09 with Fiction categories.
Swinging from South Africa to England: one woman's hunt for her birth mother in an all-too-believable near future in which an antibiotic crisis has decimated the population. A prescient, thrilling debut. 'Combines the excitement of a medical thriller à la Michael Crichton with sensitive characterisation and social insight in a timely debut novel all the more remarkable for being conceived and written before the current pandemic' Guardian 'STUNNING and terrifying ... The Waiting Rooms wrenches your heart in every way possible, but written with such humanity and emotion' Miranda Dickinson 'Chillingly close to reality, this gripping thriller brims with authenticity ... a captivating, accomplished and timely debut from an author to watch' Adam Hamdy ________________ Decades of spiralling drug resistance have unleashed a global antibiotic crisis. Ordinary infections are untreatable, and a scratch from a pet can kill. A sacrifice is required to keep the majority safe: no one over seventy is allowed new antibiotics. The elderly are sent to hospitals nicknamed 'The Waiting Rooms' ... hospitals where no one ever gets well. Twenty years after the crisis takes hold, Kate begins a search for her birth mother, armed only with her name and her age. As Kate unearths disturbing facts about her mother's past, she puts her family in danger and risks losing everything. Because Kate is not the only secret that her mother is hiding. Someone else is looking for her, too. Sweeping from an all-too-real modern Britain to a pre-crisis South Africa, The Waiting Rooms is epic in scope, richly populated with unforgettable characters, and a tense, haunting vision of a future that is only a few mutations away. ________________ 'Engrossing and eye-opening, with heart-stopping plot twists ... a stunning medical thriller set in a terrifying possible future' Foreword Reviews 'A touching, gut-wrenching story of family mystery and tragedy ... a thriller that punches on two fronts – heart AND mind' The Sun 'Gripping and disturbing ... the medical research is convincing, the scenarios plausible, and the story is emotionally engaging. This is an incredible debut!' Gill Paul 'If the themes are dark and topical, the writing is exquisite. Breath held, I got to the finale with my heart in my mouth. Eve Smith weaves a complex and clever tale, merging countries and timelines; the result is a superb and satisfying novel' Louise Beech 'Margaret Atwood is one of my all-time writing heroes and The Handmaid's Tale is probably the best book I've ever read. Eve Smith and The Waiting Rooms really do challenge that long-held crown...' Random Things through My Letterbox 'Thoroughly engaging ... an eye-opening read' Crime Fiction Lover 'A novel of our times' Trip Fiction 'Haunting, honest and horrifying in its reality ... An epic and thrilling read' Book Literati 'Stunning dystopian debut. A prescient and alarming tale that seems just a whisper from reality' Suzy Apsley ' The Waiting Rooms will certainly distract us from the real world for a few hours and this is the immeasurable value of fiction. It gives hope that, as in Eve Smith's fictitious world, the possibility of a happy ending still exists' Die Burger ' The Waiting Rooms is a seriously impressive debut, a novel that is intuitive and chilling, one that will resonate with all in this current climate' Swirl & Thread
Genome Editing And Engineering
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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2018-08-23
Genome Editing And Engineering written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-23 with Science categories.
A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.
Genome Stability
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Author : Igor Kovalchuk
language : en
Publisher: Academic Press
Release Date : 2021-07-17
Genome Stability written by Igor Kovalchuk and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-17 with Science categories.
Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Stem Cell Genetics For Biomedical Research
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Author : Raul Delgado-Morales
language : en
Publisher: Springer
Release Date : 2018-06-27
Stem Cell Genetics For Biomedical Research written by Raul Delgado-Morales and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-27 with Science categories.
This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.
The Crispr Cas Tool Kit For Genome Editing
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Author : Aftab Ahmad
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
The Crispr Cas Tool Kit For Genome Editing written by Aftab Ahmad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Medical categories.
This book discusses CRISPR/Cas- one of the most powerful tools available to scientists for genome editing. CRISPR/Cas is not only a genome editing tool, but researchers have also engineered it for gene regulation, genome imaging, base editing and epigenome regulations. This book describes the entire toolkit for CRISPR/Cas. The opening section gives an introduction to the technique and compares it with other genome editing tools. Further section gives a historical perspective of the tool, along with its detailed classification. The next chapters describe bioinformatic tools in CRISPR/Cas, and delivery methods for CRISPR/Cas. The book also discusses about the applications of CRISPR/Cas beyond genome editing and use of CRISPR for rewriting genetic codes. The book dedicates a section to the use of CRISPR in plants. The book culminates with a chapter on the current status, challenges and shortcomings of the CRISPR/Cas genome editing tool. The book would be highly interesting to students and researchers in molecular biology, biochemistry, biotechnology, food science, agriculture and plant sciences.
Pathway Analysis For Drug Discovery
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Author : Anton Yuryev
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-17
Pathway Analysis For Drug Discovery written by Anton Yuryev and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-17 with Science categories.
This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.