Old Drugs Confronting Recent Advancements And Challenges
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Old Drugs Confronting Recent Advancements And Challenges
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Author : Anna Wiktorowska-Owczarek
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-01
Old Drugs Confronting Recent Advancements And Challenges written by Anna Wiktorowska-Owczarek and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-01 with Science categories.
Over the years, there has been an increasing demand for an effective and cost-efficient drug discovery process. The study of old and previously-approved drugs for newer indications or their re-evaluation based on newly-identified different mechanisms of action has become a major focus of drug discovery, particularly when it comes to treating chronic or complex multigenetic diseases such as cancer, autoimmune, neurodegenerative disorders, and psychiatric conditions. This approach is actually particularly appealing since it saves time and resources and reduces the risk of failure. The history of pharmacology is replete with examples of drugs that have undergone significant shifts in their clinical or preventive use over time, such as acetylsalicylic acid, thalidomide, duloxetine, and dapagliflozin. For instance, acetylsalicylic acid has been used for over a century as an anti-inflammatory and analgesic, but it is currently used as an antiplatelet agent. Thalidomide was previously removed from the market because of its teratogenic effects which were associated with the inhibition of the synthesis of tumor necrosis factor-alpha and other cytokines, but it has since emerged as an immunomodulator for the treatment of various diseases, including erythema nodosum leprosum. Intriguingly, repurposed drugs have also been shown to control synaptic potentiation associated with neurological and psychiatric disorders, which have opened unimaginable scenarios a few years ago.
Research Advances In Alcohol And Drug Problems
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Author : H.M. Annis
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Research Advances In Alcohol And Drug Problems written by H.M. Annis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
This is the tenth volume in the Research Advances series and the seventh published by Plenum Press. Volume 10 is another omnibus volume, providing specialized and advanced reviews in a number of areas related to the use of alcohol, illicit drugs, and tobacco. We include also a brief history of the Center for Alcohol Studies that gives Mark Keller's unique perspective on this noted institution. Two of the chapters are decidedly longer than the others-very long chapters have appeared occasionally in the past, and we think that it is one of the strengths of the series that we are able to accommodate such reviews. Again the editorial board has changed. After several years of service, Reginald G. Smart has stepped down. New to the board are Helen M. Annis, Michael S. Goodstadt, Lynn T. Kozlowski, and Evelyn R. Vingilis. This is likely to be the sole volume for which Goodstadt is on the board, since before completion of this volume he moved from the Addiction Research Foundation to the Center for Alcohol Studies, Rutgers University.
Fda In The Twenty First Century
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Author : Holly Fernandez Lynch
language : en
Publisher: Columbia University Press
Release Date : 2015-09-08
Fda In The Twenty First Century written by Holly Fernandez Lynch and has been published by Columbia University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-08 with Business & Economics categories.
In its decades-long effort to assure the safety, efficacy, and security of medicines and other products, the Food and Drug Administration has struggled with issues of funding, proper associations with industry, and the balance between consumer choice and consumer protection. Today, these challenges are compounded by the pressures of globalization, the introduction of novel technologies, and fast-evolving threats to public health. With essays by leading scholars and government and private-industry experts, FDA in the Twenty-First Century addresses perennial and new problems and the improvements the agency can make to better serve the public good. The collection features essays on effective regulation in an era of globalization, consumer empowerment, and comparative effectiveness, as well as questions of data transparency, conflicts of interest, industry responsibility, and innovation policy, all with an emphasis on pharmaceuticals. The book also intervenes in the debate over off-label drug marketing and the proper role of the FDA before and after a drug goes on the market. Dealing honestly and thoroughly with the FDA's successes and failures, these essays rethink the structure, function, and future of the agency and the effect policy innovations may have on regulatory institutions abroad.
Coping With Methuselah
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Author : Henry Aaron
language : en
Publisher: Rowman & Littlefield
Release Date : 2004-01-20
Coping With Methuselah written by Henry Aaron and has been published by Rowman & Littlefield this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-20 with Medical categories.
Many medical authorities predict that average life expectancy could well exceed 100 years by mid century and rise even higher soon thereafter. This astonishing prospect, brought on by the revolution in molecular biology and information technology, confronts policymakers and public health officials with a host of new questions. How will increased longevity affect local and global demographic trends, government taxation and spending, health care, the workplace, Social Security, Medicare, and Medicaid? What ethical and quality-of-life issues are raised by these new breakthroughs? In Coping with Methuselah, a group of practicing scientists and public policy experts come together to address the problems, challenges, and opportunities posed by a longer life span. This book will generate discussion in political, social, and medical circles and help prepare us for the extraordinary possibilities that the future may hold.
Public Health Service Publication
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Author :
language : en
Publisher:
Release Date : 1969
Public Health Service Publication written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with Public health categories.
Interagency Coordination In Drug Research And Regulation
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Author : United States. Congress. Senate. Committee on Government Operations. Subcommittee on Reorganization and International Organizations
language : en
Publisher:
Release Date : 1963
Interagency Coordination In Drug Research And Regulation written by United States. Congress. Senate. Committee on Government Operations. Subcommittee on Reorganization and International Organizations and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1963 with Drugs categories.
Reviews cooperative efforts among Federal and international agencies responsible for medical research on experimental drugs and regulation of pharmaceutical industry marketing practices. Includes review of thalidomide marketing and use.
Interagency Coordination In Drug Research And Regulations
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Author : United States. Congress. Senate. Government Operations
language : en
Publisher:
Release Date : 1962
Interagency Coordination In Drug Research And Regulations written by United States. Congress. Senate. Government Operations and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1962 with categories.
Interagency Coordination In Drug Research And Regulation Supplementary Exhibits And Index To Parts 1 And 2
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Author : United States. Congress. Senate. Committee on Government Operations
language : en
Publisher:
Release Date : 1963
Interagency Coordination In Drug Research And Regulation Supplementary Exhibits And Index To Parts 1 And 2 written by United States. Congress. Senate. Committee on Government Operations and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1963 with Drugs categories.
Reviews cooperative efforts among Federal and international agencies responsible for medical research on experimental drugs and regulation of pharmaceutical industry marketing practices. Includes review of thalidomide marketing and use, drugs for mental illness, neonatal pharmacology, etc.
Facing Ethical Issues
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Author : Patrick T. McCormick
language : en
Publisher: Paulist Press
Release Date : 2002
Facing Ethical Issues written by Patrick T. McCormick and has been published by Paulist Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Religion categories.
"Pat McCormick and Russ Conners build on the insights of "fundamental" Christian ethics and apply them in making concrete judgments about a number of very specific contemporary moral problems relating to the economy, war and violence, medicine, sexuality and the environment." "Facing Ethical Issues is must reading for anyone wishing to make sense of our increasingly complex world."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Interagency Coordination In Drug Research And Regulation
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Author : United States. Congress. Senate. Committee on Government Operations
language : en
Publisher:
Release Date : 1963
Interagency Coordination In Drug Research And Regulation written by United States. Congress. Senate. Committee on Government Operations and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1963 with Drugs categories.