Oligodendrocytes From Their Development To Function And Dysfunction
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Oligodendrocytes From Their Development To Function And Dysfunction
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Author : Hiroaki Wake
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-12
Oligodendrocytes From Their Development To Function And Dysfunction written by Hiroaki Wake and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-12 with Medical categories.
The Biology Of Oligodendrocytes
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Author : Patricia Armati
language : en
Publisher: Cambridge University Press
Release Date : 2010-10-21
The Biology Of Oligodendrocytes written by Patricia Armati and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-21 with Medical categories.
Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
Oligodendrocyte Physiology And Pathology Function
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Author : Markus Kipp
language : en
Publisher: MDPI
Release Date : 2021-01-06
Oligodendrocyte Physiology And Pathology Function written by Markus Kipp and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-06 with Medical categories.
The adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple sclerosis (MS) is included. This disease is associated with the development of large demyelinated plaques, oligodendrocyte destruction, and axonal degeneration, paralleled by the activation of astrocytes and microglia as well as the recruitment of peripheral immune cells to the site of tissue injury. Of note, viable oligodendrocytes and an intact myelin sheath are indispensable for neuronal health. For example, it has been shown that oligodendrocytes provide nutritional support to neurons, fast axonal transport depends on proper oligodendrocyte function, and mice deficient in mature myelin proteins eventually display severe neurodegeneration. This Special Issue contains a collection of highly relevant primary research articles as well as review articles focusing on the development, physiology, and pathology of the oligodendrocyte–axon–myelin unit.
The Role Of Glia In Neurotoxicity
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Author : Michael Aschner
language : en
Publisher: CRC Press
Release Date : 1996-03-27
The Role Of Glia In Neurotoxicity written by Michael Aschner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-03-27 with Medical categories.
It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.
Glial Dysfunction In Epileptogenesis
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Author : Kjell Heuser
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-14
Glial Dysfunction In Epileptogenesis written by Kjell Heuser and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-14 with Medical categories.
Function Dysfunction In The Nervous System
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Author : Cold Spring Harbor Laboratory
language : en
Publisher:
Release Date : 1996
Function Dysfunction In The Nervous System written by Cold Spring Harbor Laboratory and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Nervous system categories.
The Clinical Neurobiology Of The Hippocampus
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Author : Thorsten Bartsch
language : en
Publisher: Oxford University Press
Release Date : 2012-07-26
The Clinical Neurobiology Of The Hippocampus written by Thorsten Bartsch and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-26 with Medical categories.
The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. Its recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical and neurocomputational literature that presents basic mechanisms, theoretical models and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented in current literature, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. The Clinical Neurobiology of the Hippocampus explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural and psychiatric symptoms and surpasses the ability to encode, store and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia. The first part of the book covers the basic and integrative features of the hippocampus, such as the anatomy and imaging of this structure, and the basic mechanisms of hippocampal function, including the principles of hippocampus-dependent memory processing in amnesia and sleep, the mechanisms of vulnerability and adult neurogenesis as well as the effects of stress. The second part covers the various clinical manifestations in which the hippocampus is involved and in which the preceding basic mechanisms are reflected. Bringing together a broad team of experts on the basic and clinical aspects of the hippocampus, the book provides an integrative view of the hippocampus. It is invaluable for neurologists, neuroscientists, and psychiatrists, and will stimulate interdisciplinary discussions in clinical neuroscience.
Human Stem Cell Manual
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Author : Suzanne E. Peterson
language : en
Publisher: Academic Press
Release Date : 2012-08-27
Human Stem Cell Manual written by Suzanne E. Peterson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-27 with Medical categories.
This reader-friendly manual provides a practical "hands on" guide to the culture of human embryonic and somatic stem cells. By presenting methods for embryonic and adult lines side-by-side, the authors lay out an elegant and unique path to understanding the science of stem cell practice.
The Neuroscience Of Normal And Pathological Development
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Author : Colin R Martin
language : en
Publisher: Academic Press
Release Date : 2021-10-12
The Neuroscience Of Normal And Pathological Development written by Colin R Martin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-12 with Psychology categories.
Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of development-related conditions. Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. It also examines in vitro and in vivo modelling of development with stem cells and model systems.Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience Of Development: - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development - Features sections on diagnosis and biomarkers - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet: - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development - Features sections on the genetics of developmental conditions and accompanying behavior - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables
Animal Models Of Anxiety And Depression Exploring The Underlying Mechanisms Of Sex Differences
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Author : Laura B. Tucker
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-12
Animal Models Of Anxiety And Depression Exploring The Underlying Mechanisms Of Sex Differences written by Laura B. Tucker and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-12 with Science categories.