Optimal Control For Mathematical Models Of Cancer Therapies
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Optimal Control For Mathematical Models Of Cancer Therapies
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Author : Heinz Schättler
language : en
Publisher: Springer
Release Date : 2015-09-15
Optimal Control For Mathematical Models Of Cancer Therapies written by Heinz Schättler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-15 with Mathematics categories.
This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style. Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.
Geometric Optimal Control
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Author : Heinz Schättler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-26
Geometric Optimal Control written by Heinz Schättler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-26 with Mathematics categories.
This book gives a comprehensive treatment of the fundamental necessary and sufficient conditions for optimality for finite-dimensional, deterministic, optimal control problems. The emphasis is on the geometric aspects of the theory and on illustrating how these methods can be used to solve optimal control problems. It provides tools and techniques that go well beyond standard procedures and can be used to obtain a full understanding of the global structure of solutions for the underlying problem. The text includes a large number and variety of fully worked out examples that range from the classical problem of minimum surfaces of revolution to cancer treatment for novel therapy approaches. All these examples, in one way or the other, illustrate the power of geometric techniques and methods. The versatile text contains material on different levels ranging from the introductory and elementary to the advanced. Parts of the text can be viewed as a comprehensive textbook for both advanced undergraduate and all level graduate courses on optimal control in both mathematics and engineering departments. The text moves smoothly from the more introductory topics to those parts that are in a monograph style were advanced topics are presented. While the presentation is mathematically rigorous, it is carried out in a tutorial style that makes the text accessible to a wide audience of researchers and students from various fields, including the mathematical sciences and engineering. Heinz Schättler is an Associate Professor at Washington University in St. Louis in the Department of Electrical and Systems Engineering, Urszula Ledzewicz is a Distinguished Research Professor at Southern Illinois University Edwardsville in the Department of Mathematics and Statistics.
Mathematical Models Of Cancer And Different Therapies
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Author : Regina Padmanabhan
language : en
Publisher: Springer Nature
Release Date : 2020-10-31
Mathematical Models Of Cancer And Different Therapies written by Regina Padmanabhan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-31 with Technology & Engineering categories.
This book provides a unified framework for various currently available mathematical models that are used to analyze progression and regression in cancer development, and to predict its dynamics with respect to therapeutic interventions. Accurate and reliable model representations of cancer dynamics are milestones in the field of cancer research. Mathematical modeling approaches are becoming increasingly common in cancer research, as these quantitative approaches can help to validate hypotheses concerning cancer dynamics and thus elucidate the complexly interlaced mechanisms involved. Even though the related conceptual and technical information is growing at an exponential rate, the application of said information and realization of useful healthcare devices are lagging behind. In order to remedy this discrepancy, more interdisciplinary research works and course curricula need to be introduced in academic, industrial, and clinical organizations alike. To that end, this book reformulates most of the existing mathematical models as special cases of a general model, allowing readers to easily get an overall idea of cancer dynamics and its modeling. Moreover, the book will help bridge the gap between biologists and engineers, as it brings together cancer dynamics, the main steps involved in mathematical modeling, and control strategies developed for cancer management. This also allows readers in both medical and engineering fields to compare and contrast all the therapy-based models developed to date using a single source, and to identify unexplored research directions.
Optimal Control Applied To Biological Models
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Author : Suzanne Lenhart
language : en
Publisher: CRC Press
Release Date : 2007-05-07
Optimal Control Applied To Biological Models written by Suzanne Lenhart and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-07 with Mathematics categories.
From economics and business to the biological sciences to physics and engineering, professionals successfully use the powerful mathematical tool of optimal control to make management and strategy decisions. Optimal Control Applied to Biological Models thoroughly develops the mathematical aspects of optimal control theory and provides insight into t
Mathematical Modeling And Control In Life And Environmental Sciences
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Author : Sebastian Aniţa
language : en
Publisher: Springer Nature
Release Date : 2024-04-29
Mathematical Modeling And Control In Life And Environmental Sciences written by Sebastian Aniţa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-29 with Mathematics categories.
This monograph explores the use of mathematical modeling and control theory in a variety of contemporary challenges in mathematical biology and environmental sciences. Emphasizing an approach of learning by doing, the authors focus on a set of significant case studies emerging from real-world problems and illustrate how mathematical techniques and computational experiments can be employed in the search for sustainable solutions. The following topics are extensively discussed: Eradicability and control of a paradigmatic epidemic model, with a view to the existence of endemic states, their stability, and the existence of travelling waves A spatially structured epidemic model concerning malaria as an example of vector-borne epidemics Optimal harvesting problems for space-structured and age-structured population dynamics Controlling epidemics in agriculture due to pest insects The role of predators as a possible biocontrol agent of epidemics in agriculture Control by taxation of the environmental pollution produced by human activities The originality of this text is in its leitmotif – regional control – along the principle of “Think Globally, Act Locally.” Indeed, for example, in many real spatially structured ecosystems, it is practically impossible to control the relevant system by global interventions in the whole habitat. Proofs are given whenever they may serve as a guide to the introduction of new concepts. Each chapter includes a comprehensive description of the numerical methods used for the computational experiments, and MATLAB© codes for many of the numerical simulations are available for download. Several challenging open problems are also provided to stimulate future research. This text is aimed at mathematicians, engineers, and other scientists working in areas such as biology, medicine, and economics. Graduate and advanced undergraduate students of a quantitative subject related to the analysis and applications of dynamical systems and their control will also find it to be a valuable resource.
Analysis And Geometry In Control Theory And Its Applications
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Author : Piernicola Bettiol
language : en
Publisher: Springer
Release Date : 2015-09-01
Analysis And Geometry In Control Theory And Its Applications written by Piernicola Bettiol and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-01 with Mathematics categories.
Since the 1950s control theory has established itself as a major mathematical discipline, particularly suitable for application in a number of research fields, including advanced engineering design, economics and the medical sciences. However, since its emergence, there has been a need to rethink and extend fields such as calculus of variations, differential geometry and nonsmooth analysis, which are closely tied to research on applications. Today control theory is a rich source of basic abstract problems arising from applications, and provides an important frame of reference for investigating purely mathematical issues. In many fields of mathematics, the huge and growing scope of activity has been accompanied by fragmentation into a multitude of narrow specialties. However, outstanding advances are often the result of the quest for unifying themes and a synthesis of different approaches. Control theory and its applications are no exception. Here, the interaction between analysis and geometry has played a crucial role in the evolution of the field. This book collects some recent results, highlighting geometrical and analytical aspects and the possible connections between them. Applications provide the background, in the classical spirit of mutual interplay between abstract theory and problem-solving practice.
Large Scale Scientific Computing
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Author : Ivan Lirkov
language : en
Publisher: Springer Nature
Release Date : 2020-02-13
Large Scale Scientific Computing written by Ivan Lirkov and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-13 with Computers categories.
This book constitutes revised papers from the 12th International Conference on Large-Scale Scientific Computing, LSSC 2019, held in Sozopol, Bulgaria, in June 2019. The 70 papers presented in this volume were carefully reviewed and selected from 81 submissions. The book also contains two invited talks. The papers were organized in topical sections named as follows: control and optimization of dynamical systems; meshfree and particle methods; fractional diffusion problems: numerical methods, algorithms and applications; pore scale flow and transport simulation; tensors based algorithms and structures in optimization and applications; HPC and big data: algorithms and applications; large-scale models: numerical methods, parallel computations and applications; monte carlo algorithms: innovative applications in conjunctions with other methods; application of metaheuristics to large-scale problems; large scale machine learning: multiscale algorithms and performance guarantees; and contributed papers.
Dynamical Models Of Biology And Medicine
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Author : Yang Kuang
language : en
Publisher: MDPI
Release Date : 2019-10-04
Dynamical Models Of Biology And Medicine written by Yang Kuang and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with Technology & Engineering categories.
Mathematical and computational modeling approaches in biological and medical research are experiencing rapid growth globally. This Special Issue Book intends to scratch the surface of this exciting phenomenon. The subject areas covered involve general mathematical methods and their applications in biology and medicine, with an emphasis on work related to mathematical and computational modeling of the complex dynamics observed in biological and medical research. Fourteen rigorously reviewed papers were included in this Special Issue. These papers cover several timely topics relating to classical population biology, fundamental biology, and modern medicine. While the authors of these papers dealt with very different modeling questions, they were all motivated by specific applications in biology and medicine and employed innovative mathematical and computational methods to study the complex dynamics of their models. We hope that these papers detail case studies that will inspire many additional mathematical modeling efforts in biology and medicine
Mathematical Oncology 2013
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Author : Alberto d'Onofrio
language : en
Publisher: Springer
Release Date : 2014-10-16
Mathematical Oncology 2013 written by Alberto d'Onofrio and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-16 with Mathematics categories.
With chapters on free boundaries, constitutive equations, stochastic dynamics, nonlinear diffusion–consumption, structured populations, and applications of optimal control theory, this volume presents the most significant recent results in the field of mathematical oncology. It highlights the work of world-class research teams, and explores how different researchers approach the same problem in various ways. Tumors are complex entities that present numerous challenges to the mathematical modeler. First and foremost, they grow. Thus their spatial mean field description involves a free boundary problem. Second, their interiors should be modeled as nontrivial porous media using constitutive equations. Third, at the end of anti-cancer therapy, a small number of malignant cells remain, making the post-treatment dynamics inherently stochastic. Fourth, the growth parameters of macroscopic tumors are non-constant, as are the parameters of anti-tumor therapies. Changes in these parameters may induce phenomena that are mathematically equivalent to phase transitions. Fifth, tumor vascular growth is random and self-similar. Finally, the drugs used in chemotherapy diffuse and are taken up by the cells in nonlinear ways. Mathematical Oncology 2013 will appeal to graduate students and researchers in biomathematics, computational and theoretical biology, biophysics, and bioengineering.
Intelligent Information And Database Systems
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Author : Ngoc Thanh Nguyen
language : en
Publisher: Springer Nature
Release Date : 2020-03-03
Intelligent Information And Database Systems written by Ngoc Thanh Nguyen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-03 with Computers categories.
The two-volume set LNAI 12033 and 11034 constitutes the refereed proceedings of the 12th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2020, held in Phuket, Thailand, in March 2020. The total of 105 full papers accepted for publication in these proceedings were carefully reviewed and selected from 285 submissions. The papers of the first volume are organized in the following topical sections: Knowledge Engineering and Semantic Web, Natural Language Processing, Decision Support and Control Systems, Computer Vision Techniques, Machine Learning and Data Mining, Deep Learning Models, Advanced Data Mining Techniques and Applications, Multiple Model Approach to Machine Learning. The papers of the second volume are divided into these topical sections: Application of Intelligent Methods to Constrained Problems, Automated Reasoning with Applications in Intelligent Systems, Current Trends in Arti cial Intelligence, Optimization, Learning,and Decision-Making in Bioinformatics and Bioengineering, Computer Vision and Intelligent Systems, Data Modelling and Processing for Industry 4.0, Intelligent Applications of Internet of Things and Data AnalysisTechnologies, Intelligent and Contextual Systems, Intelligent Systems and Algorithms in Information Sciences, Intelligent Supply Chains and e-Commerce, Privacy, Security and Trust in Arti cial Intelligence, Interactive Analysis of Image, Video and Motion Data in LifeSciences.