Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms

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Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms

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Author : Mohamed Ibrahim
language : en
Publisher: CRC Press
Release Date : 2020-05-31

Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms written by Mohamed Ibrahim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-31 with Technology & Engineering categories.

A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.

Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms

DOWNLOAD eBooks

Author : Mohamed Ibrahim
language : en
Publisher: CRC Press
Release Date : 2020-05-31

Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms written by Mohamed Ibrahim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-31 with Technology & Engineering categories.

A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.

Secure And Trustworthy Cyberphysical Microfluidic Biochips

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Author : Jack Tang
language : en
Publisher: Springer
Release Date : 2019-05-28

Secure And Trustworthy Cyberphysical Microfluidic Biochips written by Jack Tang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-28 with Technology & Engineering categories.

This book describes novel hardware security and microfluidic biochip design methodologies to protect against tampering attacks in cyberphysical microfluidic biochips (CPMBs). It also provides a general overview of this nascent area of research, which will prove to be a vital resource for practitioners in the field.This book shows how hardware-based countermeasures and design innovations can be a simple and effective last line of defense, demonstrating that it is no longer justifiable to ignore security and trust in the design phase of biochips.

Digital Microfluidic Biochips

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Author : Krishnendu Chakrabarty
language : en
Publisher: CRC Press
Release Date : 2018-10-03

Digital Microfluidic Biochips written by Krishnendu Chakrabarty and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-03 with Technology & Engineering categories.

Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

Factories Of The Future

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Author : Tullio Tolio
language : en
Publisher: Springer
Release Date : 2019-02-14

Factories Of The Future written by Tullio Tolio and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-14 with Technology & Engineering categories.

This book is open access under a CC BY 4.0 license.This book presents results relevant in the manufacturing research field, that are mainly aimed at closing the gap between the academic investigation and the industrial application, in collaboration with manufacturing companies. Several hardware and software prototypes represent the key outcome of the scientific contributions that can be grouped into five main areas, representing different perspectives of the factory domain:1) Evolutionary and reconfigurable factories to cope with dynamic production contexts characterized by evolving demand and technologies, products and processes.2) Factories for sustainable production, asking for energy efficiency, low environmental impact products and processes, new de-production logics, sustainable logistics.3) Factories for the People who need new kinds of interactions between production processes, machines, and human beings to offer a more comfortable and stimulating working environment.4) Factories for customized products that will be more and more tailored to the final user’s needs and sold at cost-effective prices.5) High performance factories to yield the due production while minimizing the inefficiencies caused by failures, management problems, maintenance.This books is primarily targeted to academic researchers and industrial practitioners in the manufacturing domain.

Connected Environments For The Internet Of Things

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Author : Zaigham Mahmood
language : en
Publisher: Springer
Release Date : 2018-01-05

Connected Environments For The Internet Of Things written by Zaigham Mahmood and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-05 with Computers categories.

This comprehensive text/reference presents a broad-ranging overview of device connectivity in distributed computing environments, supporting the vision of an Internet of Things (IoT). Expert perspectives are provided by an international selection of researchers from both industry and academia, covering issues of communication, security, privacy, interoperability, networking, access control, and authentication. In addition to discussing state-of-the-art research and practice, the book includes corporate analyses offering a balanced view of benefits and limitations, and numerous case studies illustrating the challenges and practical solutions. Topics and features: discusses issues of security and privacy in connected environments, with a specific focus on the impact of the IoT paradigm on enterprise information systems; examines the challenges of managing big data in IoT environments, and proposes cloud computing-based solutions to the limitations inherent in the IoT paradigm; suggests approaches to overcome service-level interoperability problems in the IoT environment; introduces a mobile IoT simulator designed to evaluate the behavior of IoT systems, in addition to a novel approach to manage hyper-connectivity in the IoT; describes the use of the Essence framework to model software development methods, and highlights the benefits of integrating data from smart buildings and IoT devices; presents an asymmetric schema matching mechanism for IoT interoperability, and explores the topic of automatic provenance capture at the middleware level; reviews emerging network topologies and communication technologies, and advises on the adoption of a data distribution service as a middleware platform for IoT systems. This practically-oriented volume serves as a complete reference for students, researchers and practitioners of distributed computing, providing insights into the latest approaches, technologies, and frameworks relevant to the IoT environment.

Nanobioengineering

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Author : Bhupinder Singh
language : en
Publisher: CRC Press
Release Date : 2018-11-02

Nanobioengineering written by Bhupinder Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-02 with Science categories.

The objective of this book is to provide the fundamental comprehension of a broad range of topics in an integrated volume such that readership hailing from diverse disciplines can rapidly acquire the necessary background for applying it in pertinent research and development field.

Advances In Microfluidics Technology For Diagnostics And Detection

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Author : David Kinahan
language : en
Publisher: MDPI
Release Date : 2021-09-06

Advances In Microfluidics Technology For Diagnostics And Detection written by David Kinahan and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-06 with Technology & Engineering categories.

Microfluidics and lab-on-a-chip have, in recent years, come to the forefront in diagnostics and detection. At point-of-care, in the emergency room, and at the hospital bed or GP clinic, lab-on-a-chip offers the potential to rapidly detect time-critical and life-threatening diseases such as sepsis and bacterial meningitis. Furthermore, portable and user-friendly diagnostic platforms can enable disease diagnostics and detection in resource-poor settings where centralised laboratory facilities may not be available. At point-of-use, microfluidics and lab-on-chip can be applied in the field to rapidly identify plant pathogens, thus reducing the need for damaging broad spectrum pesticides while also reducing food losses. Microfluidics can also be applied to the continuous monitoring of water quality and can support policy-makers and protection agencies in protecting the environment. Perhaps most excitingly, microfluidics also offers the potential to enable entirely new diagnostic tests that cannot be implemented using conventional laboratory tools. Examples of microfluidics at the frontier of new medical diagnostic tests include early detection of cancers through circulating tumour cells (CTCs) and highly sensitive genetic tests using droplet-based digital PCR. This Special Issue on “Advances in Microfluidics Technology for Diagnostics and Detection” aims to gather outstanding research and to carry out comprehensive coverage of all aspects related to microfluidics in diagnostics and detection.

Single Cell Analysis

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Author : Tuhin Subhra Santra
language : en
Publisher: MDPI
Release Date : 2021-06-02

Single Cell Analysis written by Tuhin Subhra Santra and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Science categories.

Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological context of cells, such as tumor progression or issues around stem cells. Single-cell omics can provide valuable information about functional mutation and a copy number of variations of cells. Information from single-cell investigations can help to produce a better understanding of intracellular interactions and environmental responses of cellular organelles, which can be beneficial for therapeutics development and diagnostics purposes. This Special Issue is inviting articles related to single-cell analysis and its advantages, limitations, and future prospects regarding health benefits.

Micro Nanofluidic Devices For Single Cell Analysis

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Author : Fan-Gang Tseng
language : en
Publisher: MDPI
Release Date : 2018-10-04

Micro Nanofluidic Devices For Single Cell Analysis written by Fan-Gang Tseng and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-04 with Electronic book categories.

This book is a printed edition of the Special Issue "Micro/Nanofluidic Devices for Single Cell Analysis" that was published in Micromachines